7YM8
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![BU of 7ym8 by Molmil](/molmil-images/mine/7ym8) | Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to oxymetazoline | 分子名称: | CHOLESTEROL HEMISUCCINATE, Oxymetazoline, alpha1A adrenergic receptor, ... | 著者 | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | 登録日 | 2022-07-27 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
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8JLZ
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![BU of 8jlz by Molmil](/molmil-images/mine/8jlz) | ST1936-5HT6R complex | 分子名称: | 2-(5-chloranyl-2-methyl-1~{H}-indol-3-yl)-N,N-dimethyl-ethanamine, 5-hydroxytryptamine receptor 6, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wen, X, Sun, J. | 登録日 | 2023-06-04 | 公開日 | 2023-06-28 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structural insight into the selective agonist ST1936 binding of serotonin receptor 5-HT6. Biochem.Biophys.Res.Commun., 671, 2023
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8H4I
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![BU of 8h4i by Molmil](/molmil-images/mine/8h4i) | DHA-bound FFAR4 in complex with Gs | 分子名称: | DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | He, Y, Yin, H. | 登録日 | 2022-10-10 | 公開日 | 2023-06-21 | 最終更新日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
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8H4L
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![BU of 8h4l by Molmil](/molmil-images/mine/8h4l) | DHA-bound FFAR4 in complex with Gq | 分子名称: | DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | He, Y, Yin, H. | 登録日 | 2022-10-10 | 公開日 | 2023-06-21 | 最終更新日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
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8HMP
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![BU of 8hmp by Molmil](/molmil-images/mine/8hmp) | GPR52 with Gs and c17 | 分子名称: | G-protein coupled receptor 52, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Chen, B, Xu, F. | 登録日 | 2022-12-05 | 公開日 | 2023-06-21 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Allosteric coupling between G-protein binding and extracellular ligand binding sites in GPR52 revealed by 19 F-NMR and cryo-electron microscopy. MedComm (2020), 4, 2023
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8H4K
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![BU of 8h4k by Molmil](/molmil-images/mine/8h4k) | GW9508-bound FFAR4 in complex with Gq | 分子名称: | 3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | He, Y, Yin, H. | 登録日 | 2022-10-10 | 公開日 | 2023-06-21 | 最終更新日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
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8IYS
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![BU of 8iys by Molmil](/molmil-images/mine/8iys) | TUG891-bound FFAR4 in complex with Gq | 分子名称: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | He, Y, Yin, H. | 登録日 | 2023-04-06 | 公開日 | 2023-06-21 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
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8J19
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![BU of 8j19 by Molmil](/molmil-images/mine/8j19) | Cryo-EM structure of the LY237-bound GPR84 receptor-Gi complex | 分子名称: | 6-nonylpyridine-2,4-diol, Antibody fragment ScFv16, G-protein coupled receptor 84, ... | 著者 | Liu, H, Yin, W, Xu, H.E. | 登録日 | 2023-04-12 | 公開日 | 2023-06-21 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84. Nat Commun, 14, 2023
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8J1A
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![BU of 8j1a by Molmil](/molmil-images/mine/8j1a) | Cryo-EM structure of the GPR84 receptor-Gi complex with no ligand modeled | 分子名称: | Antibody fragment ScFv16, G-protein coupled receptor 84, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, H, Yin, W, Xu, H.E. | 登録日 | 2023-04-12 | 公開日 | 2023-06-21 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84. Nat Commun, 14, 2023
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8J18
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![BU of 8j18 by Molmil](/molmil-images/mine/8j18) | Cryo-EM structure of the 3-OH-C12-bound GPR84 receptor-Gi complex | 分子名称: | (3R)-3-HYDROXYDODECANOIC ACID, Antibody fragment ScFv16, G-protein coupled receptor 84, ... | 著者 | Liu, H, Yin, W, Xu, H.E. | 登録日 | 2023-04-12 | 公開日 | 2023-06-21 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84. Nat Commun, 14, 2023
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8IRR
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![BU of 8irr by Molmil](/molmil-images/mine/8irr) | Dopamine Receptor D1R-Gs-Rotigotine complex | 分子名称: | CHOLESTEROL, D(1A) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. | 登録日 | 2023-03-19 | 公開日 | 2023-06-21 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural genomics of the human dopamine receptor system. Cell Res., 33, 2023
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8IRV
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![BU of 8irv by Molmil](/molmil-images/mine/8irv) | Dopamine Receptor D5R-Gs-Rotigotine complex | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. | 登録日 | 2023-03-19 | 公開日 | 2023-06-07 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural genomics of the human dopamine receptor system. Cell Res., 33, 2023
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8IRT
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![BU of 8irt by Molmil](/molmil-images/mine/8irt) | Dopamine Receptor D3R-Gi-Rotigotine complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. | 登録日 | 2023-03-19 | 公開日 | 2023-06-07 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural genomics of the human dopamine receptor system. Cell Res., 33, 2023
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8IRS
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![BU of 8irs by Molmil](/molmil-images/mine/8irs) | Dopamine Receptor D2R-Gi-Rotigotine complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. | 登録日 | 2023-03-19 | 公開日 | 2023-06-07 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural genomics of the human dopamine receptor system. Cell Res., 33, 2023
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7XXI
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![BU of 7xxi by Molmil](/molmil-images/mine/7xxi) | Cryo-EM structure of the purinergic receptor P2Y12R in complex with 2MeSADP and Gi | 分子名称: | 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Tan, Q, Li, B, Han, S, Zhao, Q, Wu, B. | 登録日 | 2022-05-30 | 公開日 | 2023-06-07 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R. Protein Cell, 14, 2023
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7XXH
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![BU of 7xxh by Molmil](/molmil-images/mine/7xxh) | Cryo-EM structure of the purinergic receptor P2Y1R in complex with 2MeSADP and G11 | 分子名称: | 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), Guanine nucleotide-binding protein G(11) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Tan, Q, Li, B, Han, S, Zhao, Q, Wu, B. | 登録日 | 2022-05-30 | 公開日 | 2023-06-07 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R. Protein Cell, 14, 2023
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7Y3G
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![BU of 7y3g by Molmil](/molmil-images/mine/7y3g) | Cryo-EM structure of a class A orphan GPCR | 分子名称: | G-protein coupled receptor 12, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, Z.J, Hua, T, Li, H, Zhang, J.Y, Luo, F. | 登録日 | 2022-06-10 | 公開日 | 2023-06-07 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Structural insight into the constitutive activity of human orphan receptor GPR12. Sci Bull (Beijing), 68, 2023
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8CIC
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![BU of 8cic by Molmil](/molmil-images/mine/8cic) | Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with clinical candidate Etrumadenant | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-azanyl-6-[1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]-1,2,3-triazol-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile, ... | 著者 | Cheng, R.K.Y, Markovic-Mueller, S, Hennig, M. | 登録日 | 2023-02-09 | 公開日 | 2023-05-31 | 最終更新日 | 2023-06-14 | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | 主引用文献 | Crystal structure of adenosine A 2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction. Commun Chem, 6, 2023
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8HJ5
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![BU of 8hj5 by Molmil](/molmil-images/mine/8hj5) | Cryo-EM structure of Gq-coupled MRGPRX1 bound with Compound-16 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | 著者 | Gan, B, Yu, L.Y, Ren, R.B. | 登録日 | 2022-11-22 | 公開日 | 2023-05-31 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Mechanism of agonist-induced activation of the human itch receptor MRGPRX1. Plos Biol., 21, 2023
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8IW4
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![BU of 8iw4 by Molmil](/molmil-images/mine/8iw4) | Cryo-EM structure of the SPE-bound mTAAR9-Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K. | 登録日 | 2023-03-29 | 公開日 | 2023-05-31 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Structural basis of amine odorant perception by a mammal olfactory receptor. Nature, 618, 2023
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8IW9
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![BU of 8iw9 by Molmil](/molmil-images/mine/8iw9) | Cryo-EM structure of the CAD-bound mTAAR9-Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K. | 登録日 | 2023-03-29 | 公開日 | 2023-05-31 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structural basis of amine odorant perception by a mammal olfactory receptor. Nature, 618, 2023
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8IW7
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![BU of 8iw7 by Molmil](/molmil-images/mine/8iw7) | Cryo-EM structure of the PEA-bound mTAAR9-Gs complex | 分子名称: | 2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K. | 登録日 | 2023-03-29 | 公開日 | 2023-05-31 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Structural basis of amine odorant perception by a mammal olfactory receptor. Nature, 618, 2023
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8ITF
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![BU of 8itf by Molmil](/molmil-images/mine/8itf) | Cryo-EM structure of the DMCHA-bound mTAAR9-Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K. | 登録日 | 2023-03-22 | 公開日 | 2023-05-31 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Structural basis of amine odorant perception by a mammal olfactory receptor. Nature, 618, 2023
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8IWM
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![BU of 8iwm by Molmil](/molmil-images/mine/8iwm) | Cryo-EM structure of the PEA-bound mTAAR9 complex | 分子名称: | 2-PHENYLETHYLAMINE, Trace amine-associated receptor 9 | 著者 | Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K. | 登録日 | 2023-03-30 | 公開日 | 2023-05-31 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | Structural basis of amine odorant perception by a mammal olfactory receptor. Nature, 618, 2023
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8IWE
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![BU of 8iwe by Molmil](/molmil-images/mine/8iwe) | Cryo-EM structure of the SPE-mTAAR9 complex | 分子名称: | SPERMIDINE, Trace amine-associated receptor 9 | 著者 | Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K. | 登録日 | 2023-03-29 | 公開日 | 2023-05-31 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis of amine odorant perception by a mammal olfactory receptor. Nature, 618, 2023
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