PDB: 1205 件ウェブページステータス検索Chemie searchBIRD

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7TRQ	Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator VU0467154 分子名称: 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, 5-amino-3,4-dimethyl-N-{[4-(trifluoromethanesulfonyl)phenyl]methyl}thieno[2,3-c]pyridazine-6-carboxamide, Antibody fragment scFv16, ... 著者 Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. 登録日 2022-01-30 公開日 2023-05-17 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
7TRS	Human M4 muscarinic acetylcholine receptor complex with Gi1 and the endogenous agonist acetylcholine 分子名称: ACETYLCHOLINE, Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. 登録日 2022-01-30 公開日 2023-05-17 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
7TRP	Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator LY2033298 分子名称: 3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment scFv16, ... 著者 Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. 登録日 2022-01-30 公開日 2023-05-17 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
7TRK	Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo 分子名称: 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. 登録日 2022-01-29 公開日 2023-05-17 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
8GUQ	Cryo-EM structure of CB2-G protein complex 分子名称: Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wu, L.J, Hua, T, Liu, Z.J, Li, X.T, Chang, H. 登録日 2022-09-13 公開日 2023-05-10 最終更新日 2023-09-27 実験手法 ELECTRON MICROSCOPY (3.08 Å) 主引用文献 Structural basis of selective cannabinoid CB 2 receptor activation. Nat Commun, 14, 2023
8GUS	Cryo-EM structure of HU-CB2-G protein complex 分子名称: Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wu, L.J, Hua, T, Liu, Z.J, Li, X.T, Chang, H. 登録日 2022-09-13 公開日 2023-05-10 実験手法 ELECTRON MICROSCOPY (2.97 Å) 主引用文献 Structural basis of selective cannabinoid CB 2 receptor activation. Nat Commun, 14, 2023
8GUT	Cryo-EM structure of LEI-CB2-Gi complex 分子名称: 1-[[4-[5-fluoranyl-6-[(oxan-4-ylamino)methyl]pyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Liu, Z.J, Hua, T, Li, X.T, Chang, H, Wu, L.J. 登録日 2022-09-13 公開日 2023-05-10 最終更新日 2023-05-24 実験手法 ELECTRON MICROSCOPY (2.98 Å) 主引用文献 Structural basis of selective cannabinoid CB 2 receptor activation. Nat Commun, 14, 2023
8GUR	Cryo-EM structure of CP-CB2-G protein complex 分子名称: 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Wu, L.J, Hua, T, Liu, Z.J, Li, X.T, Chang, H. 登録日 2022-09-13 公開日 2023-05-10 実験手法 ELECTRON MICROSCOPY (2.84 Å) 主引用文献 Structural basis of selective cannabinoid CB 2 receptor activation. Nat Commun, 14, 2023
8HK5	C5aR1-Gi-C5a protein complex 分子名称: C5a anaphylatoxin chemotactic receptor 1, Complement C5, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. 登録日 2022-11-24 公開日 2023-05-10 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat.Chem.Biol., 19, 2023
8HK3	C3aR-Gi-apo protein complex 分子名称: C3a anaphylatoxin chemotactic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. 登録日 2022-11-24 公開日 2023-05-10 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat.Chem.Biol., 19, 2023
8HK2	C3aR-Gi-C3a protein complex 分子名称: C3a anaphylatoxin, C3a anaphylatoxin chemotactic receptor, CHOLESTEROL, ... 著者 Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. 登録日 2022-11-24 公開日 2023-05-10 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat.Chem.Biol., 19, 2023
8DZR	GR89,696 bound Kappa Opioid Receptor in complex with gustducin 分子名称: G alpha gustducin protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Fay, J.F, Che, T. 登録日 2022-08-08 公開日 2023-05-03 最終更新日 2023-05-31 実験手法 ELECTRON MICROSCOPY (2.61 Å) 主引用文献 Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
8DZS	GR89,696 bound Kappa Opioid Receptor in complex with Gz 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(z) subunit alpha, ... 著者 Fay, J.F, Che, T. 登録日 2022-08-08 公開日 2023-05-03 最終更新日 2023-05-24 実験手法 ELECTRON MICROSCOPY (2.65 Å) 主引用文献 Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
8DZP	momSalB bound Kappa Opioid Receptor in complex with Gi1 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Fay, J.F, Che, T. 登録日 2022-08-08 公開日 2023-05-03 最終更新日 2023-05-24 実験手法 ELECTRON MICROSCOPY (2.71 Å) 主引用文献 Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
8DZQ	momSalB bound Kappa Opioid Receptor in complex with GoA 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... 著者 Fay, J.F, Che, T. 登録日 2022-08-08 公開日 2023-05-03 最終更新日 2023-09-20 実験手法 ELECTRON MICROSCOPY (2.82 Å) 主引用文献 Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
7XJJ	Cryo-EM structure of the galanin-bound GALR1-miniGo complex 分子名称: G protein subunit alpha o1,Guanine nucleotide-binding protein G(o) subunit alpha, Galanin, Galanin receptor type 1, ... 著者 Jiang, W, Zheng, S. 登録日 2022-04-18 公開日 2023-05-03 最終更新日 2023-09-20 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural insights into galanin receptor signaling. Proc.Natl.Acad.Sci.USA, 119, 2022
7XY7	Adenosine receptor bound to a non-selective agonist in complex with a G protein obtained by cryo-EM 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Zhang, J.Y, Chen, Y, Hua, T, Song, G.J. 登録日 2022-05-31 公開日 2023-05-03 実験手法 ELECTRON MICROSCOPY (3.26 Å) 主引用文献 Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex. Sci Adv, 8, 2022
7XY6	Adenosine receptor bound to an agonist in complex with G protein obtained by cryo-EM 分子名称: 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, J.Y, Chen, Y, Hua, T, Song, G.J. 登録日 2022-05-31 公開日 2023-05-03 最終更新日 2023-05-31 実験手法 ELECTRON MICROSCOPY (2.99 Å) 主引用文献 Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex. Sci Adv, 8, 2022
7XKA	Structure of human beta2 adrenergic receptor bound to constrained epinephrine 分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Camelid Antibody Fragment, Endolysin,Beta-2 adrenergic receptor, ... 著者 Xu, X, Shonberg, J, Kaindl, J, Clark, M, Stobel, A, Maul, L, Mayer, D, Hubner, H, Venkatakrishnan, A, Dror, R, Kobilka, B.K, Sunahara, R, Liu, X, Gmeiner, P. 登録日 2022-04-19 公開日 2023-04-26 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Constrained catecholamines gain beta 2 AR selectivity through allosteric effects on pocket dynamics. Nat Commun, 14, 2023
7XK9	Structure of human beta2 adrenergic receptor bound to constrained isoproterenol 分子名称: (5R,6R)-6-(propan-2-ylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Camelid Antibody Fragment, Endolysin,Beta-2 adrenergic receptor, ... 著者 Xu, X, Shonberg, J, Kaindl, J, Clark, M, Stobel, A, Maul, L, Mayer, D, Hubner, H, Venkatakrishnan, A, Dror, R, Kobilka, B.K, Sunahara, R, Liu, X, Gmeiner, P. 登録日 2022-04-19 公開日 2023-04-26 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Constrained catecholamines gain beta 2 AR selectivity through allosteric effects on pocket dynamics. Nat Commun, 14, 2023
8G94	Structure of CD69-bound S1PR1 coupled to heterotrimeric Gi 分子名称: Early activation antigen CD69, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Chen, H, Li, X. 登録日 2023-02-21 公開日 2023-04-19 最終更新日 2023-04-26 実験手法 ELECTRON MICROSCOPY (3.15 Å) 主引用文献 Transmembrane protein CD69 acts as an S1PR1 agonist. Elife, 12, 2023
7YAC	Paltusotine-bound SSTR2-Gi complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Zhao, J, Shao, Z. 登録日 2022-06-27 公開日 2023-04-19 最終更新日 2023-09-27 実験手法 ELECTRON MICROSCOPY (3.24 Å) 主引用文献 Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine. Nat Commun, 14, 2023
7YKD	Cryo-EM structure of the human chemerin receptor 1 complex with the C-terminal nonapeptide of chemerin 分子名称: CHOLESTEROL, Chemerin-like receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Chen, G, Liao, Q, Ye, R.D, Wang, J. 登録日 2022-07-22 公開日 2023-04-19 実験手法 ELECTRON MICROSCOPY (2.81 Å) 主引用文献 Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin. Proc.Natl.Acad.Sci.USA, 120, 2023
7YAE	Octreotide-bound SSTR2-Gi complex 分子名称: CHOLESTEROL, DPN-CYS-PHE-DTR-LYS-THR-CYS-THO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Zhao, J, Shao, Z. 登録日 2022-06-28 公開日 2023-04-19 実験手法 ELECTRON MICROSCOPY (3.37 Å) 主引用文献 Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine. Nat Commun, 14, 2023
8IBV	Cryo-EM structure of the motilin-bound motilin receptor-Gq protein complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... 著者 Jiang, Y, Xu, H.E, You, C, Xu, Y. 登録日 2023-02-10 公開日 2023-04-12 実験手法 ELECTRON MICROSCOPY (3.19 Å) 主引用文献 Structural basis for motilin and erythromycin recognition by motilin receptor. Sci Adv, 9, 2023

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