8CIC

Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with clinical candidate Etrumadenant

Summary for 8CIC

Entry DOI	10.2210/pdb8cic/pdb
Descriptor	Adenosine receptor A2a,Soluble cytochrome b562, SODIUM ION, 3-[2-azanyl-6-[1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]-1,2,3-triazol-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile, ... (8 entities in total)
Functional Keywords	g-protein coupled receptor, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	57098.06
Authors	Cheng, R.K.Y.,Markovic-Mueller, S.,Hennig, M. (deposition date: 2023-02-09, release date: 2023-05-31, Last modification date: 2023-06-14)
Primary citation	Claff, T.,Schlegel, J.G.,Voss, J.H.,Vaassen, V.J.,Weisse, R.H.,Cheng, R.K.Y.,Markovic-Mueller, S.,Bucher, D.,Strater, N.,Muller, C.E. Crystal structure of adenosine A 2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction. Commun Chem, 6:106-106, 2023 Cited by PubMed: 37264098 DOI: 10.1038/s42004-023-00894-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.102 Å)

Structure validation