8GXB
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8GXC
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8EK1
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8EJO
| Crystal structure of the homeodomain of Platypus sDUX in complex with DNA | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*GP*CP*GP*TP*AP*AP*TP*CP*TP*AP*AP*TP*CP*AP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*TP*GP*AP*TP*TP*AP*GP*AP*TP*TP*AP*CP*GP*C)-3'), ... | 著者 | Yin, L, Shi, K, Aihara, H. | 登録日 | 2022-09-18 | 公開日 | 2023-09-20 | 最終更新日 | 2024-09-18 | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | 主引用文献 | Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein. Iscience, 26, 2023
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8EJP
| Crystal structure of the homeodomain of Platypus sDUX in complex with DNA containing 5-Bromouracil | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*GP*CP*GP*TP*AP*AP*TP*CP*TP*AP*AP*TP*CP*AP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*TP*GP*AP*TP*TP*AP*GP*AP*TP*TP*AP*CP*GP*C)-3'), ... | 著者 | Yin, L, Shi, K, Aihara, H. | 登録日 | 2022-09-18 | 公開日 | 2023-09-20 | 最終更新日 | 2024-09-18 | 実験手法 | X-RAY DIFFRACTION (2.174 Å) | 主引用文献 | Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein. Iscience, 26, 2023
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8EJK
| Structure of FFAR1-Gq complex bound to TAK-875 in a lipid nanodisc | 分子名称: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | 登録日 | 2022-09-17 | 公開日 | 2023-05-24 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Molecular mechanism of fatty acid activation of FFAR1. Proc.Natl.Acad.Sci.USA, 120, 2023
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8EJN
| Structure of dehaloperoxidase A in complex with 2,4-dichlorophenol | 分子名称: | 2,4-dichlorophenol, DIMETHYL SULFOXIDE, Dehaloperoxidase A, ... | 著者 | Aktar, M.S, de Serrano, V.S, Franzen, S. | 登録日 | 2022-09-17 | 公開日 | 2023-08-23 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.481 Å) | 主引用文献 | Comparative study of the binding and activation of 2,4-dichlorophenol by dehaloperoxidase A and B. J.Inorg.Biochem., 247, 2023
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8GWW
| Small-molecule Allosteric Regulation Mechanism of SHP2 | 分子名称: | 2-[4-(aminomethyl)-4-methyl-piperidin-1-yl]-5-[2,3-bis(chloranyl)phenyl]-3-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-one, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Luo, Y, Zhu, J, Yu, K, Liu, B. | 登録日 | 2022-09-17 | 公開日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Small-molecule Allosteric Regulation Mechanism of SHP2 To Be Published
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8EJC
| Structure of FFAR1-Gq complex bound to TAK-875 | 分子名称: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | 登録日 | 2022-09-16 | 公開日 | 2023-05-24 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular mechanism of fatty acid activation of FFAR1. Proc.Natl.Acad.Sci.USA, 120, 2023
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8GW8
| the human PTH1 receptor bound to an intracellular biased agonist | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Kobayashi, K, Kusakizako, T, Okamoto, H.H, Nureki, O. | 登録日 | 2022-09-16 | 公開日 | 2023-06-14 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Class B1 GPCR activation by an intracellular agonist. Nature, 618, 2023
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8B3T
| Hen Egg White Lysozyme 4s in situ crystallization | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | 著者 | Henkel, A, Galchenkova, M, Yefanov, O, Hakanpaeae, J, Chapman, H.N, Oberthuer, D. | 登録日 | 2022-09-16 | 公開日 | 2022-11-30 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | JINXED: just in time crystallization for easy structure determination of biological macromolecules. Iucrj, 10, 2023
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8B3U
| Hen Egg White Lysozyme 6s in situ crystallization | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | 著者 | Henkel, A, Galchenkova, M, Yefanov, O, Hakanpaeae, J, Chapman, H.N, Oberthuer, D. | 登録日 | 2022-09-16 | 公開日 | 2022-11-30 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | JINXED: just in time crystallization for easy structure determination of biological macromolecules. Iucrj, 10, 2023
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8B3V
| Hen Egg White Lysozyme 8s in situ crystallization | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | 著者 | Henkel, A, Galchenkova, M, Yefanov, O, Hakanpaeae, J, Chapman, H.N, Oberthuer, D. | 登録日 | 2022-09-16 | 公開日 | 2022-11-30 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | JINXED: just in time crystallization for easy structure determination of biological macromolecules. Iucrj, 10, 2023
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8GVW
| Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class2 | 分子名称: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, ... | 著者 | Won, J, Jeong, H, Lee, H.H. | 登録日 | 2022-09-16 | 公開日 | 2023-05-24 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | 主引用文献 | Molecular architecture of the G alpha i -bound TRPC5 ion channel. Nat Commun, 14, 2023
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8GVX
| Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class2 | 分子名称: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Won, J, Jeong, H, Lee, H.H. | 登録日 | 2022-09-16 | 公開日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.91 Å) | 主引用文献 | Molecular architecture of the G alpha i -bound TRPC5 ion channel. Nat Commun, 14, 2023
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8B3L
| Hen Egg White Lysozyme 2s in situ crystallization | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | 著者 | Henkel, A, Galchenkova, M, Yefanov, O, Hakanpaeae, J, Chapman, H.N, Oberthuer, D. | 登録日 | 2022-09-16 | 公開日 | 2022-12-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | JINXED: just in time crystallization for easy structure determination of biological macromolecules. Iucrj, 10, 2023
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8EJ1
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8EJ4
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8EIT
| Structure of FFAR1-Gq complex bound to DHA | 分子名称: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 1, ... | 著者 | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | 登録日 | 2022-09-15 | 公開日 | 2023-05-24 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Molecular mechanism of fatty acid activation of FFAR1. Proc.Natl.Acad.Sci.USA, 120, 2023
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8EIQ
| The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with Trikafta [elexacaftor (VX-445), tezacaftor (VX-661), ivacaftor (VX-770)] and ATP/Mg | 分子名称: | (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | 著者 | Fiedorczuk, K, Chen, J. | 登録日 | 2022-09-15 | 公開日 | 2022-10-19 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators. Science, 378, 2022
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8EIG
| The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445) and ATP/Mg | 分子名称: | (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | 著者 | Fiedorczuk, K, Chen, J. | 登録日 | 2022-09-15 | 公開日 | 2022-10-19 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators. Science, 378, 2022
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8EIO
| The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445), lumacaftor (VX-809) and ATP/Mg | 分子名称: | (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | 著者 | Fiedorczuk, K, Chen, J. | 登録日 | 2022-09-15 | 公開日 | 2022-10-19 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators. Science, 378, 2022
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8EIE
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8GUY
| human insulin receptor bound with two insulin molecules | 分子名称: | Insulin A chain, Insulin, isoform 2, ... | 著者 | Kim, J, Yunn, N, Ryu, S, Cho, Y. | 登録日 | 2022-09-14 | 公開日 | 2022-11-09 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | 主引用文献 | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13, 2022
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8B2P
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