8GWW

Small-molecule Allosteric Regulation Mechanism of SHP2

Summary for 8GWW

• Entry DOI: 10.2210/pdb8gww/pdb
• Descriptor: Tyrosine-protein phosphatase non-receptor type 11, 2-[4-(aminomethyl)-4-methyl-piperidin-1-yl]-5-[2,3-bis(chloranyl)phenyl]-3-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-one (2 entities in total)
• Functional Keywords: phosphatase, oncoprotein-inhibitor complex, oncoprotein/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 121336.59

Authors

Luo, Y.,Zhu, J.,Yu, K.,Liu, B. (deposition date: 2022-09-17, release date: 2023-09-20)

• Primary citation: Luo, Y.,Zhu, J.,Yu, K.,Liu, B.; Small-molecule Allosteric Regulation Mechanism of SHP2; To Be Published,

Experimental method

X-RAY DIFFRACTION (3 Å)