8GWW

Small-molecule Allosteric Regulation Mechanism of SHP2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein phosphatase non-receptor type 11	polymer	525	60248.0	2	UniProt (Q06124) Pfam (PF00017) Pfam (PF00102)	Homo sapiens (human)	SH-PTP2,SHP-2,Shp2
2	C, D (A, B)	2-[4-(aminomethyl)-4-methyl-piperidin-1-yl]-5-[2,3-bis(chloranyl)phenyl]-3-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-one	non-polymer		420.3	2	Chemie (KID)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	120495.9
Non-Polymers*	Number of molecules	2
	Total formula weight	840.7
All*	Total formula weight	121336.6

*Water molecules are not included.