8EJ1
Dephosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR)
Summary for 8EJ1
| Entry DOI | 10.2210/pdb8ej1/pdb |
| EMDB information | 28172 |
| Descriptor | Cystic fibrosis transmembrane conductance regulator (1 entity in total) |
| Functional Keywords | abc transporter, ion channel, folding correction, membrane protein, atp-binding protein, isomerase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 168187.30 |
| Authors | Fiedorczuk, K.,Chen, J. (deposition date: 2022-09-16, release date: 2022-10-19, Last modification date: 2022-11-09) |
| Primary citation | Fiedorczuk, K.,Chen, J. Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators. Science, 378:284-290, 2022 Cited by PubMed: 36264792DOI: 10.1126/science.ade2216 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (6.9 Å) |
Structure validation
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