8EIO

The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445), lumacaftor (VX-809) and ATP/Mg

Summary for 8EIO

• Entry DOI: 10.2210/pdb8eio/pdb
• EMDB information: 28160
• Descriptor: Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (8 entities in total)
• Functional Keywords: abc transporter, ion channel, folding correction, membrane protein, atp-binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 172322.11

Authors

Fiedorczuk, K.,Chen, J. (deposition date: 2022-09-15, release date: 2022-10-19, Last modification date: 2024-06-19)

• Primary citation: Fiedorczuk, K.,Chen, J.; Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators.; Science, 378:284-290, 2022; PubMed: 36264792; DOI: 10.1126/science.ade2216

Experimental method

ELECTRON MICROSCOPY (2.8 Å)