8EIQ
The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with Trikafta [elexacaftor (VX-445), tezacaftor (VX-661), ivacaftor (VX-770)] and ATP/Mg
Summary for 8EIQ
Entry DOI | 10.2210/pdb8eiq/pdb |
EMDB information | 28161 |
Descriptor | Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (9 entities in total) |
Functional Keywords | abc transporter, ion channel, trikafta, folding correction, membrane protein, atp-binding protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 172697.59 |
Authors | Fiedorczuk, K.,Chen, J. (deposition date: 2022-09-15, release date: 2022-10-19, Last modification date: 2022-11-23) |
Primary citation | Fiedorczuk, K.,Chen, J. Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators. Science, 378:284-290, 2022 Cited by PubMed: 36264792DOI: 10.1126/science.ade2216 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3 Å) |
Structure validation
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