8EIQ
The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with Trikafta [elexacaftor (VX-445), tezacaftor (VX-661), ivacaftor (VX-770)] and ATP/Mg
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005254 | molecular_function | chloride channel activity |
A | 0005260 | molecular_function | intracellularly ATP-gated chloride channel activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005765 | cellular_component | lysosomal membrane |
A | 0005768 | cellular_component | endosome |
A | 0005769 | cellular_component | early endosome |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006695 | biological_process | cholesterol biosynthetic process |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0006821 | biological_process | chloride transport |
A | 0006904 | biological_process | vesicle docking involved in exocytosis |
A | 0009986 | cellular_component | cell surface |
A | 0010008 | cellular_component | endosome membrane |
A | 0015106 | molecular_function | bicarbonate transmembrane transporter activity |
A | 0015108 | molecular_function | chloride transmembrane transporter activity |
A | 0015701 | biological_process | bicarbonate transport |
A | 0016020 | cellular_component | membrane |
A | 0016324 | cellular_component | apical plasma membrane |
A | 0016853 | molecular_function | isomerase activity |
A | 0016887 | molecular_function | ATP hydrolysis activity |
A | 0017081 | molecular_function | chloride channel regulator activity |
A | 0019869 | molecular_function | chloride channel inhibitor activity |
A | 0019899 | molecular_function | enzyme binding |
A | 0030165 | molecular_function | PDZ domain binding |
A | 0030301 | biological_process | cholesterol transport |
A | 0030660 | cellular_component | Golgi-associated vesicle membrane |
A | 0030669 | cellular_component | clathrin-coated endocytic vesicle membrane |
A | 0031901 | cellular_component | early endosome membrane |
A | 0032991 | cellular_component | protein-containing complex |
A | 0034220 | biological_process | monoatomic ion transmembrane transport |
A | 0034707 | cellular_component | chloride channel complex |
A | 0034976 | biological_process | response to endoplasmic reticulum stress |
A | 0035377 | biological_process | transepithelial water transport |
A | 0035774 | biological_process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
A | 0043225 | molecular_function | ATPase-coupled inorganic anion transmembrane transporter activity |
A | 0045921 | biological_process | positive regulation of exocytosis |
A | 0048240 | biological_process | sperm capacitation |
A | 0050891 | biological_process | multicellular organismal-level water homeostasis |
A | 0051087 | molecular_function | protein-folding chaperone binding |
A | 0051454 | biological_process | intracellular pH elevation |
A | 0051649 | biological_process | establishment of localization in cell |
A | 0055037 | cellular_component | recycling endosome |
A | 0055038 | cellular_component | recycling endosome membrane |
A | 0055085 | biological_process | transmembrane transport |
A | 0060081 | biological_process | membrane hyperpolarization |
A | 0070175 | biological_process | positive regulation of enamel mineralization |
A | 0071320 | biological_process | cellular response to cAMP |
A | 0071889 | molecular_function | 14-3-3 protein binding |
A | 0097186 | biological_process | amelogenesis |
A | 0106138 | molecular_function | Sec61 translocon complex binding |
A | 0140359 | molecular_function | ABC-type transporter activity |
A | 1902161 | biological_process | positive regulation of cyclic nucleotide-gated ion channel activity |
A | 1902476 | biological_process | chloride transmembrane transport |
A | 1902943 | biological_process | positive regulation of voltage-gated chloride channel activity |
A | 1904322 | biological_process | cellular response to forskolin |
Functional Information from PROSITE/UniProt
site_id | PS00211 |
Number of Residues | 15 |
Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRARISLARAV |
Chain | Residue | Details |
A | LEU548-VAL562 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 76 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
Chain | Residue | Details |
A | MET1-PHE77 |
site_id | SWS_FT_FI2 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000269|Ref.56 |
Chain | Residue | Details |
A | PHE78-GLN98 |
site_id | SWS_FT_FI3 |
Number of Residues | 99 |
Details | TOPO_DOM: Extracellular => ECO:0000269|Ref.56 |
Chain | Residue | Details |
A | PRO99-TYR122 | |
A | GLU217-SER222 | |
A | LEU320-THR339 | |
A | LEU881-TYR919 | |
A | PRO1013-TYR1014 | |
A | SER1118-ILE1131 |
site_id | SWS_FT_FI4 |
Number of Residues | 23 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000269|Ref.56 |
Chain | Residue | Details |
A | LEU123-HIS146 |
site_id | SWS_FT_FI5 |
Number of Residues | 1039 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|Ref.56 |
Chain | Residue | Details |
A | HIS147-LEU195 | |
A | MET244-LYS298 | |
A | GLN359-LEU859 | |
A | LEU941-ILE991 | |
A | THR1036-LEU1096 |
site_id | SWS_FT_FI6 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000269|Ref.56 |
Chain | Residue | Details |
A | ALA196-TRP216 |
site_id | SWS_FT_FI7 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000269|Ref.56 |
Chain | Residue | Details |
A | ALA223-MET243 |
site_id | SWS_FT_FI8 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=5 => ECO:0000269|Ref.56 |
Chain | Residue | Details |
A | ALA299-PHE319 |
site_id | SWS_FT_FI9 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=6 => ECO:0000269|Ref.56 |
Chain | Residue | Details |
A | ILE340-VAL358 |
site_id | SWS_FT_FI10 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=7 => ECO:0000269|Ref.56 |
Chain | Residue | Details |
A | ILE860-VAL880 |
site_id | SWS_FT_FI11 |
Number of Residues | 20 |
Details | TRANSMEM: Discontinuously helical; Name=8 => ECO:0000269|Ref.56 |
Chain | Residue | Details |
A | VAL920-THR940 |
site_id | SWS_FT_FI12 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=9 => ECO:0000269|Ref.56 |
Chain | Residue | Details |
A | PHE992-GLN1012 |
site_id | SWS_FT_FI13 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=10 => ECO:0000269|Ref.56 |
Chain | Residue | Details |
A | ILE1015-GLN1035 |
site_id | SWS_FT_FI14 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=11 => ECO:0000269|Ref.56 |
Chain | Residue | Details |
A | ARG1097-ILE1117 |
site_id | SWS_FT_FI15 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=12 => ECO:0000269|Ref.56 |
Chain | Residue | Details |
A | ILE1132-ASP1152 |
site_id | SWS_FT_FI16 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15528182, ECO:0000269|PubMed:20150177, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:1XMJ, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS, ECO:0007744|PDB:2BBT, ECO:0007744|PDB:2PZE, ECO:0007744|PDB:2PZF, ECO:0007744|PDB:2PZG |
Chain | Residue | Details |
A | TRP401 |
site_id | SWS_FT_FI17 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:20150177, ECO:0007744|PDB:2PZE, ECO:0007744|PDB:2PZF, ECO:0007744|PDB:2PZG |
Chain | Residue | Details |
A | SER434 |
site_id | SWS_FT_FI18 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434, ECO:0000269|PubMed:15528182, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:1XMJ, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS, ECO:0007744|PDB:2BBT |
Chain | Residue | Details |
A | GLY458 |
site_id | SWS_FT_FI19 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15528182, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS |
Chain | Residue | Details |
A | GLN493 |
site_id | SWS_FT_FI20 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0007744|PDB:3GD7 |
Chain | Residue | Details |
A | THR1220 |
site_id | SWS_FT_FI21 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434, ECO:0007744|PDB:3GD7 |
Chain | Residue | Details |
A | ARG1245 |
site_id | SWS_FT_FI22 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
Chain | Residue | Details |
A | GLY550 |
site_id | SWS_FT_FI23 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:1377674, ECO:0000269|PubMed:22119790, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:9385646 |
Chain | Residue | Details |
A | ILE661 | |
A | ILE701 | |
A | LEU738 | |
A | LEU796 |
site_id | SWS_FT_FI24 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:25330774 |
Chain | Residue | Details |
A | LEU671 |
site_id | SWS_FT_FI25 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:1377674, ECO:0000269|PubMed:22119790 |
Chain | Residue | Details |
A | PHE687 |
site_id | SWS_FT_FI26 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:22119790, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:9385646 |
Chain | Residue | Details |
A | ILE713 |
site_id | SWS_FT_FI27 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:22119790 |
Chain | Residue | Details |
A | PRO718 |
site_id | SWS_FT_FI28 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:9385646 |
Chain | Residue | Details |
A | VAL754 |
site_id | SWS_FT_FI29 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:1377674, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:9385646 |
Chain | Residue | Details |
A | VAL769 | |
A | GLN814 |
site_id | SWS_FT_FI30 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:1377674 |
Chain | Residue | Details |
A | THR791 |
site_id | SWS_FT_FI31 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:22119790 |
Chain | Residue | Details |
A | ASP1445 | |
A | LYS1457 |
site_id | SWS_FT_FI32 |
Number of Residues | 2 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:22119790 |
Chain | Residue | Details |
A | GLN525 | |
A | THR1396 |
site_id | SWS_FT_FI33 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:7518437, ECO:0000305|PubMed:20008117 |
Chain | Residue | Details |
A | SER895 | |
A | ASN901 |
site_id | SWS_FT_FI34 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:22119790 |
Chain | Residue | Details |
A | GLN689 |