8EIQ
The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with Trikafta [elexacaftor (VX-445), tezacaftor (VX-661), ivacaftor (VX-770)] and ATP/Mg
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cystic fibrosis transmembrane conductance regulator | polymer | 1479 | 168187.3 | 1 | UniProt (P13569) Pfam (PF00664) Pfam (PF00005) Pfam (PF14396) | Homo sapiens (human) | CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | B (B) | Cystic fibrosis transmembrane conductance regulator | polymer | 16 | 1379.7 | 1 | Homo sapiens (human) | ||
| 3 | C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, F (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | G (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 6 | H (A) | DODECANE | non-polymer | 170.3 | 1 | Chemie (D12) | |||
| 7 | I (A) | N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide | non-polymer | 392.5 | 1 | Chemie (VX7) | |||
| 8 | J (A) | (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide | non-polymer | 597.7 | 1 | Chemie (WJX) | |||
| 9 | K (A) | Tezacaftor | non-polymer | 520.5 | 1 | Chemie (CV6) |
Sequence modifications
A: 1 - 1480 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| - | Phe 508 | deletion |
| Gln 1371 | Glu 1371 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 169567.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 3130.6 | |
| All* | Total formula weight | 172697.6 |
