8EIG

The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445) and ATP/Mg

Summary for 8EIG

Entry DOI	10.2210/pdb8eig/pdb
EMDB information	28155
Descriptor	Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywords	abc transporter, ion channel, folding correction, membrane protein, atp-binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	170234.58
Authors	Fiedorczuk, K.,Chen, J. (deposition date: 2022-09-15, release date: 2022-10-19, Last modification date: 2022-11-23)
Primary citation	Fiedorczuk, K.,Chen, J. Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators. Science, 378:284-290, 2022 Cited by PubMed: 36264792 DOI: 10.1126/science.ade2216 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation