8EJ4

Cryo-EM structure of the active NLRP3 inflammasome disk

This is a non-PDB format compatible entry.

Summary for 8EJ4

• Entry DOI: 10.2210/pdb8ej4/pdb
• EMDB information: 28175
• Descriptor: NACHT, LRR and PYD domains-containing protein 3, Serine/threonine-protein kinase Nek7, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... (4 entities in total)
• Functional Keywords: inflammasome, cytosolic protein, immune system-transferase complex, immune system/transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 20
• Total formula weight: 1352613.25

Authors

Hao, W.,Le, X. (deposition date: 2022-09-16, release date: 2022-12-14, Last modification date: 2023-02-01)

• Primary citation: Xiao, L.,Magupalli, V.G.,Wu, H.; Cryo-EM structures of the active NLRP3 inflammasome disc.; Nature, 613:595-600, 2023; PubMed: 36442502; DOI: 10.1038/s41586-022-05570-8

Experimental method

ELECTRON MICROSCOPY (3.4 Å)