8KH5
 
 | | Cryo-EM structure of the GPR174-Gs complex bound to endogenous lysoPS | | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Nie, Y, Qiu, Z, Zheng, S, Chen, S. | | 登録日 | 2023-08-21 | | 公開日 | 2023-10-18 | | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | | 主引用文献 | Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling.
Nat Commun, 14, 2023
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8K3Q
 | | S. cerevisiae Chs1 in apo state | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Chitin synthase 1 | | 著者 | Bai, L, Chen, D. | | 登録日 | 2023-07-16 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase.
Nat Commun, 14, 2023
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8K3V
 | | S. cerevisiae Chs1 in complex with UDP-GlcNAc | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Chitin synthase 1, MAGNESIUM ION, ... | | 著者 | Bai, L, Chen, D. | | 登録日 | 2023-07-17 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase.
Nat Commun, 14, 2023
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8K3T
 | | S. cerevisiae Chs1 in complex with UDP | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Chitin synthase 1, MAGNESIUM ION, ... | | 著者 | Bai, L, Chen, D. | | 登録日 | 2023-07-17 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | | 主引用文献 | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase.
Nat Commun, 14, 2023
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8K3P
 | | S. cerevisiae Chs1 in complex with polyoxin B | | 分子名称: | (2S)-2-[[(2S,3S,4S)-5-aminocarbonyloxy-2-azanyl-3,4-bis(oxidanyl)pentanoyl]amino]-2-[(2R,3S,4R,5R)-5-[5-(hydroxymethyl)-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]ethanoic acid, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Chitin synthase 1 | | 著者 | Bai, L, Chen, D.D. | | 登録日 | 2023-07-16 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | | 主引用文献 | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase.
Nat Commun, 14, 2023
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8K7A
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8JUE
 | | Crystal structure of glutaminase C in complex with compound 11 | | 分子名称: | 2-(3-phenoxyphenyl)-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial | | 著者 | Wang, X, Hanyu, S, Tingting, D. | | 登録日 | 2023-06-26 | | 公開日 | 2023-10-11 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors.
Acs Med.Chem.Lett., 14, 2023
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8JUB
 | | Crystal structure of glutaminase C in complex with compound 27 | | 分子名称: | 3-[2-oxidanylidene-2-[[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]amino]ethyl]benzoic acid, Glutaminase kidney isoform, mitochondrial | | 著者 | Wang, X, Hanyu, S, Tingting, D. | | 登録日 | 2023-06-26 | | 公開日 | 2023-10-11 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors.
Acs Med.Chem.Lett., 14, 2023
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8KGK
 | | Cryo-EM structure of the GPR61-Gs complex | | 分子名称: | G-protein coupled receptor 61, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Nie, Y, Qiu, Z, Zheng, S. | | 登録日 | 2023-08-19 | | 公開日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | | 主引用文献 | Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling.
Nat Commun, 14, 2023
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8KH4
 | | Cryo-EM structure of the GPR161-Gs complex | | 分子名称: | CHOLESTEROL, G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Nie, Y, Qiu, Z, Zheng, S, Chen, S. | | 登録日 | 2023-08-21 | | 公開日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling.
Nat Commun, 14, 2023
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8K4B
 | | Cryo-EM structure of nucleotide-bound ComA with ZinC ion | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Competence factor transporting ATP-binding protein/permease ComA, ZINC ION | | 著者 | Yu, L, Xin, X, Min, L, Feng, H. | | 登録日 | 2023-07-17 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural basis of peptide secretion for Quorum sensing by ComA.
Nat Commun, 14, 2023
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8KE2
 | | PylRS C-terminus domain mutant bound with L-3-trifluoromethylphenylalanine and AMPNP | | 分子名称: | (2S)-2-azanyl-3-[3-(trifluoromethyl)phenyl]propanoic acid, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | | 登録日 | 2023-08-11 | | 公開日 | 2023-11-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.19639969 Å) | | 主引用文献 | Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids.
Front Genet, 14, 2023
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8KE3
 | | PylRS C-terminus domain mutant bound with D-3-trifluoromethylphenylalanine and AMPNP | | 分子名称: | (2R)-2-azanyl-3-[3-(trifluoromethyl)phenyl]propanoic acid, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | | 登録日 | 2023-08-11 | | 公開日 | 2023-11-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.89980984 Å) | | 主引用文献 | Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids.
Front Genet, 14, 2023
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8KE5
 | | PylRS C-terminus domain mutant bound with D-3-chlorophenylalanine and AMPNP | | 分子名称: | (2R)-2-azanyl-3-(3-chlorophenyl)propanoic acid, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | | 登録日 | 2023-08-11 | | 公開日 | 2023-11-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.900073 Å) | | 主引用文献 | Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids.
Front Genet, 14, 2023
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8KE6
 | | PylRS C-terminus domain mutant bound with L-3-chlorophenylalanine and AMPNP | | 分子名称: | 3-CHLORO-L-PHENYLALANINE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | | 登録日 | 2023-08-11 | | 公開日 | 2023-11-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.89570856 Å) | | 主引用文献 | Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids.
Front Genet, 14, 2023
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8KE1
 | | PylRS C-terminus domain mutant bound with L-3-bromophenylalanine and AMPNP | | 分子名称: | 3-bromo-L-phenylalanine, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | | 登録日 | 2023-08-11 | | 公開日 | 2023-11-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.50081539 Å) | | 主引用文献 | Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids.
Front Genet, 14, 2023
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8KE4
 | | PylRS C-terminus domain mutant bound with D-3-bromophenylalanine and AMPNP | | 分子名称: | (2R)-2-azanyl-3-(3-bromophenyl)propanoic acid, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | | 登録日 | 2023-08-11 | | 公開日 | 2023-11-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.75050962 Å) | | 主引用文献 | Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids.
Front Genet, 14, 2023
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8K5C
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8K5D
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8K5B
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8ODU
 | | Chaetomium thermophilum Get1/Get2 heterotetramer in complex with a Get3 dimer (amphipol) | | 分子名称: | ATPase GET3, Protein GET2,Protein GET1, ZINC ION | | 著者 | McDowell, M.A, Wild, K, Sinning, I. | | 登録日 | 2023-03-09 | | 公開日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (5 Å) | | 主引用文献 | The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
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8K0B
 | | Cryo-EM structure of TMEM63C | | 分子名称: | Calcium permeable stress-gated cation channel 1 | | 著者 | Qin, Y, Yu, D, Dong, J, Dang, S. | | 登録日 | 2023-07-08 | | 公開日 | 2023-12-06 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | | 主引用文献 | Cryo-EM structure of TMEM63C suggests it functions as a monomer.
Nat Commun, 14, 2023
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8ODV
 | | Chaetomium thermophilum Get1/Get2 heterotetramer in complex with a Get3 dimer (nanodisc) | | 分子名称: | ATPase GET3, Protein GET2,Protein GET1, ZINC ION | | 著者 | McDowell, M.A, Wild, K, Sinning, I. | | 登録日 | 2023-03-09 | | 公開日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
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7MRJ
 | | Crystal structure of a novel ubiquitin-like TINCR | | 分子名称: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | | 著者 | Forouhar, F, Morgado-Palacin, L, Brown, J.A, Martinez, T, Pedrero, J.M.G, Reglero, C, Chaudhry, I, Vaughan, J, Rodriguez-Perales, S, Allonca, E, Granda-Diaz, R, Quinn, S.A, Fernandez, A.F, Fraga, M.F, Kim, A.L, Santos-Juanes, J, Owens, D.M, Rodrigo, J.P, Saghatelian, A, Ferrando, A.A. | | 登録日 | 2021-05-07 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma.
Nat Commun, 14, 2023
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8JMV
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