PDB: 9760 件ウェブページステータス検索Chemie searchBIRD

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3LHP	Crystal structure of HIV epitope-scaffold 4E10_D0_1ISEA_004_N 4E10 Fv complex 分子名称: 1,2-ETHANEDIOL, 4E10_D0_1ISEA_004_N (T93), Fv 4E10 heavy chain, ... 著者 Holmes, M.A. 登録日 2010-01-22 公開日 2010-09-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope. Structure, 18, 2010
6AJ2	The structure of ICAM-5 triggered Enterovirus D68 virus A-particle 分子名称: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 著者 Zheng, Q.B, Zhu, R, Xu, L.F, He, M.Z, Yan, X.D, Cheng, T, Li, S.W. 登録日 2018-08-26 公開日 2018-11-07 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization Nat Microbiol, 4, 2019
3LH2	Crystal structure of HIV epitope-scaffold 4E10_1VI7A_S0_002_N 4E10 Fv complex 分子名称: 4E10_1VI7A_S0_002_N (T88), Fv 4E10 heavy chain, Fv 4E10 light chain 著者 Holmes, M.A. 登録日 2010-01-21 公開日 2010-09-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope. Structure, 18, 2010
6AJ0	The structure of Enterovirus D68 mature virion 分子名称: Capsid protein VP3, Capsid protein VP4, Viral protein 1, ... 著者 Zheng, Q.B, Zhu, R, Xu, L.F, He, M.Z, Yan, X.D, Cheng, T, Li, S.W. 登録日 2018-08-25 公開日 2018-11-07 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization Nat Microbiol, 4, 2019
3LF9	Crystal structure of HIV epitope-scaffold 4E10_D0_1IS1A_001_C 分子名称: 4E10_D0_1IS1A_001_C (T161) 著者 Holmes, M.A. 登録日 2010-01-16 公開日 2010-09-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope. Structure, 18, 2010
7UI0	Post-fusion ectodomain of HSV-1 gB in complex with HSV010-13 Fab 分子名称: Envelope glycoprotein B, HSV10-13 Fab Heavy chain, HSV10-13 Light chain 著者 Windsor, I.W, Kong, S.L, Garforth, S.J, Almo, S.C, Harrison, S.C. 登録日 2022-03-28 公開日 2023-02-08 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 A non-neutralizing glycoprotein B monoclonal antibody protects against herpes simplex virus disease in mice. J.Clin.Invest., 133, 2023
7UHZ	Post-fusion ectodomain of HSV-1 gB in complex with BMPC-23 Fab 分子名称: BMPC-23 Fab Heavy chain, BMPC-23 Fab Light chain, Envelope glycoprotein B 著者 Windsor, I.W, Kong, S.L, Garforth, S.J, Almo, S.C, Harrison, S.C. 登録日 2022-03-28 公開日 2023-02-08 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 A non-neutralizing glycoprotein B monoclonal antibody protects against herpes simplex virus disease in mice. J.Clin.Invest., 133, 2023
6AJ3	The structure of Enterovirus D68 procapsid 分子名称: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 著者 Zheng, Q.B, Zhu, R, Xu, L.F, He, M.Z, Yan, X.D, Cheng, T, Li, S.W. 登録日 2018-08-26 公開日 2018-11-07 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization Nat Microbiol, 4, 2019
8KB6	Crystal Structure of Canine TNF-alpha 分子名称: Tumor necrosis factor 著者 Lee, C.C, Wang, A.H.-J. 登録日 2023-08-03 公開日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.850166 Å) 主引用文献 Structure-based development of a canine TNF-alpha-specific antibody using adalimumab as a template. Protein Sci., 33, 2024
8CSJ	Cryo-EM structure of NTD-directed non-neutralizing antibody 4-33 in complex with prefusion SARS-CoV-2 spike glycoprotein 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(2-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Reddem, E.R, Shapiro, L. 登録日 2022-05-12 公開日 2023-05-17 実験手法 ELECTRON MICROSCOPY (3.53 Å) 主引用文献 Cryo-EM structure of NTD-directed non-neutralizing antibody 4-33 in complex with prefusion SARS-CoV-2 spike glycoprotein To Be Published
8CHE	TLT-1 binding Fab of the bispecific antibody HMB-001 in complex with the TLT-1 stalk peptide 分子名称: Fab heavy chain, Fab light chain, Trem-like transcript 1 protein 著者 Johansson, E, Schluckebier, G. 登録日 2023-02-07 公開日 2023-12-27 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders Nat Cardiovasc Res, 3, 2024
8CN9	Factor VII binding Fab of the bispecific antibody HMB-001 in complex with Factor VII 分子名称: CALCIUM ION, CESIUM ION, Coagulation factor VII, ... 著者 Schluckebier, G, Johansson, E. 登録日 2023-02-22 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders Nat Cardiovasc Res, 2023
7DV4	Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4 分子名称: 1,2-ETHANEDIOL, 4003-1(VH), Cytotoxic T-lymphocyte protein 4 著者 Li, H, Gan, X, He, Y. 登録日 2021-01-12 公開日 2022-01-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 An anti-CTLA-4 heavy chain-only antibody with enhanced T reg depletion shows excellent preclinical efficacy and safety profile. Proc.Natl.Acad.Sci.USA, 119, 2022
2KH2	Solution structure of a scFv-IL-1B complex 分子名称: Interleukin-1 beta, scFv 著者 Wilkinson, I.C, Hall, C.J, Veverka, V, Muskett, F.W, Stephens, P.E, Taylor, R.J, Henry, A.J, Carr, M.D. 登録日 2009-03-23 公開日 2009-09-08 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 High resolution NMR-based model for the structure of a scFv-IL-1beta complex: potential for NMR as a key tool in therapeutic antibody design and development. J.Biol.Chem., 284, 2009
3LF6	Crystal structure of HIV epitope-scaffold 4E10_1XIZA_S0_001_N 分子名称: PHOSPHATE ION, Putative phosphotransferase system 著者 Holmes, M.A. 登録日 2010-01-15 公開日 2010-09-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope. Structure, 18, 2010
3LG7	Crystal structure of HIV epitope-scaffold 4E10_S0_1EZ3A_002_C 分子名称: 4E10_S0_1EZ3A_002_C (T246), SULFATE ION 著者 Holmes, M.A. 登録日 2010-01-19 公開日 2010-09-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope. Structure, 18, 2010
2H9G	Crystal structure of phage derived Fab BdF1 with human Death Receptor 5 (DR5) 分子名称: Fab BdF1, heavy chain, light chain, ... 著者 Hymowitz, S.G, Compaan, D.M. 登録日 2006-06-09 公開日 2006-08-08 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Activation of the Proapoptotic Death Receptor DR5 by Oligomeric Peptide and Antibody Agonists. J.Mol.Biol., 361, 2006
3FKU	Crystal structure of influenza hemagglutinin (H5) in complex with a broadly neutralizing antibody F10 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, Neutralizing antibody F10, ... 著者 Hwang, W.C, Santelli, E, Stec, B, Wei, G, Cadwell, G, Bankston, L.A, Sui, J, Perez, S, Aird, D, Chen, L.M, Ali, M, Murakami, A, Yammanuru, A, Han, T, Cox, N, Donis, R.O, Liddington, R.C, Marasco, W.A. 登録日 2008-12-17 公開日 2009-02-24 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nat.Struct.Mol.Biol., 16, 2009
5DT1	Crystal structure of human Fab CAP256-VRC26.25, a potent V1V2-directed HIV-1 broadly neutralizing antibody 分子名称: Fab Heavy chain of broadly neutralizing antibody VRC26.25, Fab Light chain of broadly neutralizing antibody VRC26.25, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Gorman, J, Kwong, P.D. 登録日 2015-09-17 公開日 2015-10-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.954 Å) 主引用文献 New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency. J.Virol., 90, 2015
1H8S	Three-dimensional structure of anti-ampicillin single chain Fv fragment complexed with the hapten. 分子名称: (2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, MUTANT AL2 6E7P9G, SULFATE ION 著者 Burmester, J, Spinelli, S, Pugliese, L, Krebber, A, Honegger, A, Jung, S, Schimmele, B, Cambillau, C, Pluckthun, A. 登録日 2001-02-15 公開日 2001-08-02 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Selection, Characterization and X-Ray Structure of Anti-Ampicillin Single-Chain Fv Fragments from Phage-Displayed Murine Antibody Libraries J.Mol.Biol., 309, 2001
7Y0W	Local structure of BD55-5514 and BD55-5840 Fab and Omicron BA.1 RBD complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BD55-5514H, BD55-5514L, ... 著者 Zhang, Z, Xiao, J. 登録日 2022-06-06 公開日 2022-09-28 最終更新日 2023-04-12 実験手法 ELECTRON MICROSCOPY (3.42 Å) 主引用文献 Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents. Cell Rep, 41, 2022
7Y0C	Crystal structure of BD55-1403 and SARS-CoV-2 Omicron RBD 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BD55-1403 Fab heavy chain, BD55-1403 Fab light chain, ... 著者 Zhang, Z, Xiao, J. 登録日 2022-06-04 公開日 2022-09-28 最終更新日 2023-04-12 実験手法 X-RAY DIFFRACTION (2.94 Å) 主引用文献 Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents. Cell Rep, 41, 2022
5T0Y	2A10 Antibody FAB fragment 分子名称: 2A10 FAB fragment heavy chain, 2A10 FAB fragment light chain, SULFATE ION 著者 Jackson, C.J, Fisher, C. 登録日 2016-08-17 公開日 2017-06-21 実験手法 X-RAY DIFFRACTION (3.011 Å) 主引用文献 Restricted antibody diversity and low affinity limit antibody responses to the Plasmodium circumsporozoite protein To Be Published
3B2U	Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ... 著者 Ferguson, K.M, Li, S, Kussie, P. 登録日 2007-10-19 公開日 2008-02-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8. Structure, 16, 2008
3B2V	Crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ... 著者 Ferguson, K.M, Li, S, Kussie, P. 登録日 2007-10-19 公開日 2008-02-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8. Structure, 16, 2008

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