3B2U
Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8
Summary for 3B2U
Entry DOI | 10.2210/pdb3b2u/pdb |
Related | 3B2V |
Descriptor | IMC-11F8 Fab Light chain, IMC-11F8 Fab Heavy chain, Epidermal growth factor receptor, ... (10 entities in total) |
Functional Keywords | cell surface receptor; glycoprotein; antigen:antibody complex; fab fragment; antitumor; drug, anti-oncogene, atp-binding, cell cycle, disease mutation, kinase, membrane, nucleotide-binding, phosphoprotein, secreted, transferase, transmembrane, tyrosine-protein kinase, immune system-transferase complex, immune system/transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 24 |
Total formula weight | 577651.09 |
Authors | Ferguson, K.M.,Li, S.,Kussie, P. (deposition date: 2007-10-19, release date: 2008-02-19, Last modification date: 2023-08-30) |
Primary citation | Li, S.,Kussie, P.,Ferguson, K.M. Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8. Structure, 16:216-227, 2008 Cited by PubMed: 18275813DOI: 10.1016/j.str.2007.11.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.58 Å) |
Structure validation
Download full validation report