3B2U

Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0002250	biological_process	adaptive immune response
D	0003823	molecular_function	antigen binding
D	0005576	cellular_component	extracellular region
D	0005886	cellular_component	plasma membrane
D	0006955	biological_process	immune response
D	0016064	biological_process	immunoglobulin mediated immune response
D	0050853	biological_process	B cell receptor signaling pathway
D	0070062	cellular_component	extracellular exosome
D	0071735	cellular_component	IgG immunoglobulin complex
D	0072562	cellular_component	blood microparticle
G	0002250	biological_process	adaptive immune response
G	0003823	molecular_function	antigen binding
G	0005576	cellular_component	extracellular region
G	0005886	cellular_component	plasma membrane
G	0006955	biological_process	immune response
G	0016064	biological_process	immunoglobulin mediated immune response
G	0050853	biological_process	B cell receptor signaling pathway
G	0070062	cellular_component	extracellular exosome
G	0071735	cellular_component	IgG immunoglobulin complex
G	0072562	cellular_component	blood microparticle
K	0002250	biological_process	adaptive immune response
K	0003823	molecular_function	antigen binding
K	0005576	cellular_component	extracellular region
K	0005886	cellular_component	plasma membrane
K	0006955	biological_process	immune response
K	0016064	biological_process	immunoglobulin mediated immune response
K	0050853	biological_process	B cell receptor signaling pathway
K	0070062	cellular_component	extracellular exosome
K	0071735	cellular_component	IgG immunoglobulin complex
K	0072562	cellular_component	blood microparticle
L	0002250	biological_process	adaptive immune response
L	0003823	molecular_function	antigen binding
L	0005576	cellular_component	extracellular region
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0016064	biological_process	immunoglobulin mediated immune response
L	0050853	biological_process	B cell receptor signaling pathway
L	0070062	cellular_component	extracellular exosome
L	0071735	cellular_component	IgG immunoglobulin complex
L	0072562	cellular_component	blood microparticle
O	0002250	biological_process	adaptive immune response
O	0003823	molecular_function	antigen binding
O	0005576	cellular_component	extracellular region
O	0005886	cellular_component	plasma membrane
O	0006955	biological_process	immune response
O	0016064	biological_process	immunoglobulin mediated immune response
O	0050853	biological_process	B cell receptor signaling pathway
O	0070062	cellular_component	extracellular exosome
O	0071735	cellular_component	IgG immunoglobulin complex
O	0072562	cellular_component	blood microparticle
R	0002250	biological_process	adaptive immune response
R	0003823	molecular_function	antigen binding
R	0005576	cellular_component	extracellular region
R	0005886	cellular_component	plasma membrane
R	0006955	biological_process	immune response
R	0016064	biological_process	immunoglobulin mediated immune response
R	0050853	biological_process	B cell receptor signaling pathway
R	0070062	cellular_component	extracellular exosome
R	0071735	cellular_component	IgG immunoglobulin complex
R	0072562	cellular_component	blood microparticle
U	0002250	biological_process	adaptive immune response
U	0003823	molecular_function	antigen binding
U	0005576	cellular_component	extracellular region
U	0005886	cellular_component	plasma membrane
U	0006955	biological_process	immune response
U	0016064	biological_process	immunoglobulin mediated immune response
U	0050853	biological_process	B cell receptor signaling pathway
U	0070062	cellular_component	extracellular exosome
U	0071735	cellular_component	IgG immunoglobulin complex
U	0072562	cellular_component	blood microparticle
X	0002250	biological_process	adaptive immune response
X	0003823	molecular_function	antigen binding
X	0005576	cellular_component	extracellular region
X	0005886	cellular_component	plasma membrane
X	0006955	biological_process	immune response
X	0016064	biological_process	immunoglobulin mediated immune response
X	0050853	biological_process	B cell receptor signaling pathway
X	0070062	cellular_component	extracellular exosome
X	0071735	cellular_component	IgG immunoglobulin complex
X	0072562	cellular_component	blood microparticle

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR192-HIS198
H	TYR202-HIS208

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	776
Details	Domain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10731668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12297049","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12297050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12620237","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20837704","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MOX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UV7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10731668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12297050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12620237","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20837704","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UV7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8962717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12297050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12620237","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20837704","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8962717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UV7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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