8CHE
TLT-1 binding Fab of the bispecific antibody HMB-001 in complex with the TLT-1 stalk peptide
Summary for 8CHE
Entry DOI | 10.2210/pdb8che/pdb |
Descriptor | Fab heavy chain, Fab light chain, Trem-like transcript 1 protein, ... (4 entities in total) |
Functional Keywords | tlt-1, fab, bispecific antibody, hmb-001, blood clotting |
Biological source | Homo sapiens More |
Total number of polymer chains | 6 |
Total formula weight | 102035.60 |
Authors | Johansson, E.,Schluckebier, G. (deposition date: 2023-02-07, release date: 2023-12-27, Last modification date: 2024-07-10) |
Primary citation | Gandhi, P.S.,Zivkovic, M.,Ostergaard, H.,Bonde, A.C.,Elm, T.,Lovgreen, M.N.,Schluckebier, G.,Johansson, E.,Olsen, O.H.,Olsen, E.H.N.,de Bus, I.A.,Bloem, K.,Alskar, O.,Rea, C.J.,Bjorn, S.E.,Schutgens, R.E.,Sorensen, B.,Urbanus, R.T.,Faber, J.H. A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders Nat Cardiovasc Res, 3:166-185, 2024 Cited by DOI: 10.1038/s44161-023-00418-4PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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