8CHE

TLT-1 binding Fab of the bispecific antibody HMB-001 in complex with the TLT-1 stalk peptide

Summary for 8CHE

• Entry DOI: 10.2210/pdb8che/pdb
• Descriptor: Fab heavy chain, Fab light chain, Trem-like transcript 1 protein, ... (4 entities in total)
• Functional Keywords: tlt-1, fab, bispecific antibody, hmb-001, blood clotting
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 102035.60

Authors

Johansson, E.,Schluckebier, G. (deposition date: 2023-02-07, release date: 2023-12-27)

• Primary citation: Gandhi, P.S.,Zivkovic, M.,Oestergaard, H.,Bonde, A.C.,Loevgreen, M.N.,Schluckebier, G.,Johansson, E.,Rea, C.J.,Soerensen, B.,Schutgens, R.E.,Urbanus, R.T.,Faber, J.H.; HMB-001: A Novel Bispecific Antibody Accumulating and Targeting Endogenous FVIIa to Activated Platelets for Subcutaneous Prophylaxis in Multiple Bleeding Disorders Including Glanzmann Thrombasthenia.; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.49 Å)