3B2V

Crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8

Summary for 3B2V

• Entry DOI: 10.2210/pdb3b2v/pdb
• Related: 3B2U
• Descriptor: IMC-11F8 FAB Light chain, IMC-11F8 FAB Heavy chain, Epidermal growth factor receptor, ... (6 entities in total)
• Functional Keywords: cell surface receptor; glycoprotein; antigen:antibody complex; fab fragment; antitumor; drug, anti-oncogene, atp-binding, cell cycle, disease mutation, kinase, membrane, nucleotide-binding, phosphoprotein, secreted, transferase, transmembrane, tyrosine-protein kinase, immune system-transferase complex, immune system/transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 117734.41

Authors

Ferguson, K.M.,Li, S.,Kussie, P. (deposition date: 2007-10-19, release date: 2008-02-19, Last modification date: 2023-08-30)

• Primary citation: Li, S.,Kussie, P.,Ferguson, K.M.; Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8.; Structure, 16:216-227, 2008; PubMed: 18275813; DOI: 10.1016/j.str.2007.11.009

Experimental method

X-RAY DIFFRACTION (3.3 Å)