3FKU

Crystal structure of influenza hemagglutinin (H5) in complex with a broadly neutralizing antibody F10

Summary for 3FKU

• Entry DOI: 10.2210/pdb3fku/pdb
• Related: 2FK0 2GHW 2IBX
• Descriptor: Hemagglutinin, Neutralizing antibody F10, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: influenza, hemagglutinin, neutralizing antibody, scfv, h5, f10, cell membrane, envelope protein, fusion protein, membrane, transmembrane, virion, cleavage on pair of basic residues, glycoprotein, lipoprotein, palmitate, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Influenza A virus; More
• Cellular location: Virion membrane; Single-pass type I membrane protein (Potential): Q2F4V2
• Total number of polymer chains: 18
• Total formula weight: 538427.88

Authors

Hwang, W.C.,Santelli, E.,Stec, B.,Wei, G.,Cadwell, G.,Bankston, L.A.,Sui, J.,Perez, S.,Aird, D.,Chen, L.M.,Ali, M.,Murakami, A.,Yammanuru, A.,Han, T.,Cox, N.,Donis, R.O.,Liddington, R.C.,Marasco, W.A. (deposition date: 2008-12-17, release date: 2009-02-24, Last modification date: 2020-07-29)

• Primary citation: Sui, J.,Hwang, W.C.,Perez, S.,Wei, G.,Aird, D.,Chen, L.M.,Santelli, E.,Stec, B.,Cadwell, G.,Ali, M.,Wan, H.,Murakami, A.,Yammanuru, A.,Han, T.,Cox, N.J.,Bankston, L.A.,Donis, R.O.,Liddington, R.C.,Marasco, W.A.; Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses.; Nat.Struct.Mol.Biol., 16:265-273, 2009; PubMed: 19234466; DOI: 10.1038/nsmb.1566

Experimental method

X-RAY DIFFRACTION (3.2 Å)