3FKU

Crystal structure of influenza hemagglutinin (H5) in complex with a broadly neutralizing antibody F10

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I... (A, C, E, G, I...)	Hemagglutinin	polymer	338	38466.6	6	UniProt (Q5EP31) Pfam (PF00509) UniProt (by SIFTS) (Q6J8F6)	Influenza A virus (A/Viet Nam/1203/2004(H5N1))
2	B, D, F, H, J... (B, D, F, H, J...)	Hemagglutinin HA2 chain	polymer	182	20980.2	6	UniProt (A8UDR4) Pfam (PF00509) UniProt (by SIFTS) (Q2F4V2)	Influenza A virus (A/Viet Nam/1203/2004(H5N1))
3	M, N, O, P, Q... (X, Y, Z, S, T...)	Neutralizing antibody F10	polymer	280	29280.2	6		Homo sapiens (human)
4	AA, CA, S, U, W... (a, c, M, O, Q...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	6	In PDB GlyTouCan (G42666HT)
5	BA, DA, T, V, X... (b, d, N, P, R...)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	6	In PDB GlyTouCan (G15407YE)

Sequence modifications

A, C, E, G, I, K: 5 - 334 (UniProt: Q5EP31)

PDB	External Database	Details
Ala -3	-	expression tag
Asp -2	-	expression tag
Pro -1	-	expression tag
Gly 0	-	expression tag
Tyr 1	-	expression tag
Leu 2	-	expression tag
Leu 3	-	expression tag
Glu 4	-	expression tag

B, D, F, H, J, L: 1 - 176 (UniProt: A8UDR4)

PDB	External Database	Details
Arg 177	-	expression tag
Ser 178	-	expression tag
Leu 179	-	expression tag
Val 180	-	expression tag
Pro 181	-	expression tag
Arg 182	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	18
	Total formula weight	532362.2
Branched	Number of molecules	12
	Total formula weight	6065.7
All*	Total formula weight	538427.9

*Water molecules are not included.