PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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8FUP	Bromodomain of CBP liganded with BMS-536924 and CCS-1477 分子名称: (3M)-4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-benzimidazol-2-yl]pyridin-2(1H)-one, (6S)-1-[3,4-bis(fluoranyl)phenyl]-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(4-methoxycyclohexyl)benzimidazol-2-yl]piperidin-2-one, 1,2-ETHANEDIOL, ... 著者 Schonbrunn, E, Bikowitz, M. 登録日 2023-01-18 公開日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural basis of CBP and EP300 interaction with kinase inhibitors To Be Published
8FXA	Bromodomain of CBP liganded with iCBP4 分子名称: (6S)-1-[3,5-bis(trifluoromethyl)phenyl]-6-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}piperidin-2-one, 1,2-ETHANEDIOL, CREB-binding protein 著者 Schonbrunn, E, Bikowitz, M. 登録日 2023-01-24 公開日 2024-02-07 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nat Commun, 15, 2024
6ZLX	The structure of the ClpX-associated factor PDIP38 分子名称: PLATINUM (II) ION, Polymerase delta-interacting protein 2 著者 Zeth, K, Dougan, D. 登録日 2020-07-01 公開日 2021-07-14 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (3.394 Å) 主引用文献 PDIP38 is a novel adaptor-like modulator of the mitochondrial AAA+ protease CLPXP To Be Published
8FXN	Bromodomain of CBP liganded with iCBP7 分子名称: 1,2-ETHANEDIOL, CREB-binding protein, tert-butyl {(1R,4s)-4-[(5M)-2-[(2S)-1-(3-tert-butylphenyl)-6-oxopiperidin-2-yl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1H-benzimidazol-1-yl]cyclohexyl}carbamate 著者 Schonbrunn, E, Bikowitz, M. 登録日 2023-01-25 公開日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition To be published
8FXO	Bromodomain of CBP liganded with iCBP8 分子名称: (6S)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}piperidin-2-one, CREB-binding protein 著者 Schonbrunn, E, Bikowitz, M. 登録日 2023-01-25 公開日 2024-02-07 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nat Commun, 15, 2024
6ZWK	Crystal structure of the phosphorylated C-terminal tail of histone H2AX in complex with a specific nanobody (C6 gammaXbody) 分子名称: CHLORIDE ION, Histone H2AX, SODIUM ION, ... 著者 McEwen, A.G, Moeglin, E, Desplancq, D, Weiss, E, Poterszman, A. 登録日 2020-07-28 公開日 2021-07-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 A Novel Nanobody Precisely Visualizes Phosphorylated Histone H2AX in Living Cancer Cells under Drug-Induced Replication Stress. Cancers (Basel), 13, 2021
6ZSX	M2 mutant (R111K:Y134F:T54V:R132Q:P39Y:R59Y) of human cellular retinoic acid binding protein II - 4 conjugate 分子名称: Cellular retinoic acid-binding protein 2, methyl (~{Z})-2-methyl-3-phenyl-prop-2-enoate 著者 Tassone, G, Pozzi, C, Mangani, S. 登録日 2020-07-16 公開日 2021-07-28 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Xanthopsin-Like Systems via Site-Specific Click-Functionalization of a Retinoic Acid Binding Protein. Chembiochem, 23, 2022
6ZSW	M2 mutant (R111K:Y134F:T54V:R132Q:P39Y:R59Y) of human cellular retinoic acid binding protein II - 6 conjugate 分子名称: ACETATE ION, Cellular retinoic acid-binding protein 2, methyl (~{Z})-3-(4-hydroxyphenyl)-2-methyl-prop-2-enoate 著者 Tassone, G, Pozzi, C, Mangani, S. 登録日 2020-07-16 公開日 2021-07-28 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Xanthopsin-Like Systems via Site-Specific Click-Functionalization of a Retinoic Acid Binding Protein. Chembiochem, 23, 2022
6XAW	Crystal Structure Analysis of SIN3-UME6 分子名称: BROMIDE ION, Transcriptional regulatory protein SIN3, Transcriptional regulatory protein UME6 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2020-06-04 公開日 2021-06-09 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Crystal Structure Analysis of SIN3-UME6 To be published
8G6T	Bromodomain of CBP liganded with inhibitor iCBP2 分子名称: (6S)-1-(3,4-dibromophenyl)-6-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}piperidin-2-one, CREB-binding protein, NICKEL (II) ION 著者 Schonbrunn, E, Bikowitz, M. 登録日 2023-02-15 公開日 2024-02-21 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nat Commun, 15, 2024
5XE0	Crystal structure of EV-D68-3Dpol in complex with GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, Genome polyprotein 著者 Xie, W, Wang, C, Wang, Z, Li, Q, Wang, C. 登録日 2017-03-30 公開日 2017-06-28 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure and Thermostability Characterization of Enterovirus D68 3Dpol J. Virol., 91, 2017
3HGG	Crystal Structure of CmeR Bound to Cholic Acid 分子名称: CHOLIC ACID, CmeR 著者 Routh, M.D, Yang, F. 登録日 2009-05-13 公開日 2010-06-30 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Structural basis for anionic ligand recognition by multidrug binding proteins: Crystal structures of CmeR-bile acid complexes To be Published
6O6X	Crystal structure of Csm6 W14A/E337A mutant in complex with cA4 by cocrystallization 分子名称: Csm6, Cyclic RNA cA4 著者 Jia, N, Patel, D.J. 登録日 2019-03-07 公開日 2019-07-31 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4Cleavage with ApA>p Formation Terminating RNase Activity. Mol.Cell, 75, 2019
6XDJ	Crystal Structure Analysis of MBP-SIN3 分子名称: Maltodextrin-binding protein,Transcriptional regulatory protein SIN3, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2020-06-10 公開日 2021-06-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structure Analysis of MBP-SIN3 To be published
5XGB	Crystal structure of the PAS-GGDEF-EAL domain of PA0861 from Pseudomonas aeruginosa 分子名称: Uncharacterized protein 著者 Liu, C, Liew, C.W, Sreekanth, R, Lescar, J. 登録日 2017-04-13 公開日 2017-12-20 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Insights into Biofilm Dispersal Regulation from the Crystal Structure of the PAS-GGDEF-EAL Region of RbdA from Pseudomonas aeruginosa. J. Bacteriol., 200, 2018
5TSN	Crystal structures of Norwalk virus polymerase bound to an RNA primer-template duplex 分子名称: MANGANESE (II) ION, Norwalk virus polymerase, RNA (5'-R(*UP*GP*CP*CP*CP*GP*GP*G)-3') 著者 Shaik, M.M, Ng, K.K. 登録日 2016-10-30 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Norovirus RNA-dependent RNA polymerase: A computational study of metal-binding preferences. Proteins, 85, 2017
7A1O	FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 4-ethyl-2-oxoglutarate, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER) 分子名称: 4-ethyl-2-oxoglutarate, CONSENSUS ANKYRIN REPEAT DOMAIN, Hypoxia-inducible factor 1-alpha inhibitor, ... 著者 Nakashima, Y, Brewitz, L, Schofield, C.J. 登録日 2020-08-13 公開日 2021-08-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases. Nat Commun, 12, 2021
7A1Q	FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 3-(carboxycarbonyl)cyclopentane-1-carboxylic acid, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER) 分子名称: 3-(carboxycarbonyl)cyclopentane-1-carboxylic acid, CONSENSUS ANKYRIN REPEAT DOMAIN, Hypoxia-inducible factor 1-alpha inhibitor, ... 著者 Nakashima, Y, Brewitz, L, Schofield, C.J. 登録日 2020-08-13 公開日 2021-08-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases. Nat Commun, 12, 2021
7A1P	FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 4-propyl-2-oxoglutarate, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER) 分子名称: (4~{S})-2-oxidanylidene-4-propyl-pentanedioic acid, CONSENSUS ANKYRIN REPEAT DOMAIN, Hypoxia-inducible factor 1-alpha inhibitor, ... 著者 Nakashima, Y, Brewitz, L, Schofield, C.J. 登録日 2020-08-13 公開日 2021-08-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases. Nat Commun, 12, 2021
7A1M	FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-propyl-2-oxoglutarate 分子名称: 3-propyl-2-oxoglutarate, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ... 著者 Nakashima, Y, Brewitz, L, Schofield, C.J. 登録日 2020-08-13 公開日 2021-08-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases. Nat Commun, 12, 2021
7A1N	FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 3-methyl-2-oxoglutarate, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER) 分子名称: (3~{S})-3-methyl-2-oxidanylidene-pentanedioic acid, CONSENSUS ANKYRIN REPEAT DOMAIN, Hypoxia-inducible factor 1-alpha inhibitor, ... 著者 Nakashima, Y, Brewitz, L, Schofield, C.J. 登録日 2020-08-13 公開日 2021-08-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases. Nat Commun, 12, 2021
5X5P	Human serum transferrin bound to ruthenium NTA 分子名称: FE (III) ION, MALONATE ION, NITRILOTRIACETIC ACID, ... 著者 Sun, H, Wang, M. 登録日 2017-02-17 公開日 2018-02-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Binding of ruthenium and osmium at non‐iron sites of transferrin accounts for their iron-independent cellular uptake. J.Inorg.Biochem., 234, 2022
7A1L	FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-methyl-2-oxoglutarate 分子名称: (3~{S})-3-methyl-2-oxidanylidene-pentanedioic acid, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ... 著者 Nakashima, Y, Brewitz, L, Schofield, C.J. 登録日 2020-08-13 公開日 2021-08-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases. Nat Commun, 12, 2021
7A1J	FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-(3-phenylpropyl)-2-oxoglutarate 分子名称: 3-(3-phenylpropyl)-2-oxoglutarate, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ... 著者 Nakashima, Y, Brewitz, L, Schofield, C.J. 登録日 2020-08-13 公開日 2021-08-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases. Nat Commun, 12, 2021
7A1S	FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 3-methyl-2-oxoglutarate, AND TANKYRASE-2 (TNKS2) FRAGMENT PEPTIDE (21-MER) 分子名称: (3~{S})-3-methyl-2-oxidanylidene-pentanedioic acid, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ... 著者 Nakashima, Y, Brewitz, L, Schofield, C.J. 登録日 2020-08-13 公開日 2021-08-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases. Nat Commun, 12, 2021

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