7A1P

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 4-propyl-2-oxoglutarate, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER)

Summary for 7A1P

Entry DOI	10.2210/pdb7a1p/pdb
Descriptor	Hypoxia-inducible factor 1-alpha inhibitor, CONSENSUS ANKYRIN REPEAT DOMAIN, ZINC ION, ... (6 entities in total)
Functional Keywords	hypoxia-inducible factor asparagine hydroxylase, dioxygenase, oxidoreductase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	43035.52
Authors	Nakashima, Y.,Brewitz, L.,Schofield, C.J. (deposition date: 2020-08-13, release date: 2021-08-25, Last modification date: 2024-01-31)
Primary citation	Nakashima, Y.,Brewitz, L.,Tumber, A.,Salah, E.,Schofield, C.J. 2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases. Nat Commun, 12:6478-6478, 2021 Cited by PubMed: 34759269 DOI: 10.1038/s41467-021-26673-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation