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7A1M

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-propyl-2-oxoglutarate

Summary for 7A1M
Entry DOI10.2210/pdb7a1m/pdb
DescriptorHypoxia-inducible factor 1-alpha inhibitor, ZINC ION, 3-propyl-2-oxoglutarate, ... (5 entities in total)
Functional Keywordshypoxia-inducible factor asparagine hydroxylase, dioxygenase, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight40870.06
Authors
Nakashima, Y.,Brewitz, L.,Schofield, C.J. (deposition date: 2020-08-13, release date: 2021-08-25, Last modification date: 2024-01-31)
Primary citationNakashima, Y.,Brewitz, L.,Tumber, A.,Salah, E.,Schofield, C.J.
2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Nat Commun, 12:6478-6478, 2021
Cited by
PubMed: 34759269
DOI: 10.1038/s41467-021-26673-2
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.18 Å)
Structure validation

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