7A1S

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 3-methyl-2-oxoglutarate, AND TANKYRASE-2 (TNKS2) FRAGMENT PEPTIDE (21-MER)

Summary for 7A1S

• Entry DOI: 10.2210/pdb7a1s/pdb
• Descriptor: Hypoxia-inducible factor 1-alpha inhibitor, TANKYRASE-2, SULFATE ION, ... (6 entities in total)
• Functional Keywords: hypoxia-inducible factor asparagine hydroxylase, dioxygenase, oxidoreductase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 43551.72

Authors

Nakashima, Y.,Brewitz, L.,Schofield, C.J. (deposition date: 2020-08-13, release date: 2021-08-25, Last modification date: 2024-01-31)

• Primary citation: Nakashima, Y.,Brewitz, L.,Tumber, A.,Salah, E.,Schofield, C.J.; 2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.; Nat Commun, 12:6478-6478, 2021; PubMed: 34759269; DOI: 10.1038/s41467-021-26673-2

Experimental method

X-RAY DIFFRACTION (2.01 Å)