6ZWK

Crystal structure of the phosphorylated C-terminal tail of histone H2AX in complex with a specific nanobody (C6 gammaXbody)

Summary for 6ZWK

Entry DOI	10.2210/pdb6zwk/pdb
Descriptor	gammaXbody, Histone H2AX, SODIUM ION, ... (5 entities in total)
Functional Keywords	nanobody, phosphopeptide-recognition protein, gamma-h2ax, immune system
Biological source	Vicugna pacos (alpaca) More
Total number of polymer chains	12
Total formula weight	106914.98
Authors	McEwen, A.G.,Moeglin, E.,Desplancq, D.,Weiss, E.,Poterszman, A. (deposition date: 2020-07-28, release date: 2021-07-21, Last modification date: 2024-01-31)
Primary citation	Moeglin, E.,Desplancq, D.,Stoessel, A.,Massute, C.,Ranniger, J.,McEwen, A.G.,Zeder-Lutz, G.,Oulad-Abdelghani, M.,Chiper, M.,Lafaye, P.,Di Ventura, B.,Didier, P.,Poterszman, A.,Weiss, E. A Novel Nanobody Precisely Visualizes Phosphorylated Histone H2AX in Living Cancer Cells under Drug-Induced Replication Stress. Cancers (Basel), 13:-, 2021 Cited by PubMed: 34282773 DOI: 10.3390/cancers13133317 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation