2FEC
| Structure of the E203Q mutant of the Cl-/H+ exchanger CLC-ec1 from E.Coli | 分子名称: | Fab fragment, heavy chain, light chain, ... | 著者 | Accardi, A, Walden, M.P, Nguitragool, W, Jayaram, H, Williams, C, Miller, C. | 登録日 | 2005-12-15 | 公開日 | 2006-01-03 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (3.967 Å) | 主引用文献 | Separate ion pathways in a Cl-/H+ exchanger J.Gen.Physiol., 126, 2005
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2FI4
| Crystal structure of a BPTI variant (Cys14->Ser) in complex with trypsin | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, Cationic trypsin, ... | 著者 | Zakharova, E, Horvath, M.P, Goldenberg, D.P. | 登録日 | 2005-12-27 | 公開日 | 2006-01-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Functional and structural roles of the Cys14-Cys38 disulfide of bovine pancreatic trypsin inhibitor. J.Mol.Biol., 382, 2008
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5HAP
| OXA-48 beta-lactamase - S70A mutant | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, Beta-lactamase, ... | 著者 | Stojanoski, V, Adamski, C.J, Hu, L, Mehta, S.C, Sankaran, B, Prasad, B.V.V, Palzkill, T.G. | 登録日 | 2015-12-30 | 公開日 | 2016-09-07 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine beta-Lactamases by Relieving Steric Strain. Biochemistry, 55, 2016
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5HAQ
| OXa-48 beta-lactamase mutant - S70G | 分子名称: | Beta-lactamase, CADMIUM ION, FORMIC ACID | 著者 | Stojanoski, V, Adamski, C.J, Hu, L, Mehta, S.C, Sankaran, B, Prasad, B.V.V, Palzkill, T.G. | 登録日 | 2015-12-30 | 公開日 | 2016-09-07 | 最終更新日 | 2019-12-11 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine beta-Lactamases by Relieving Steric Strain. Biochemistry, 55, 2016
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2G5T
| Crystal structure of human dipeptidyl peptidase IV (DPPIV) complexed with cyanopyrrolidine (C5-pro-pro) inhibitor 21ag | 分子名称: | 3-{[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHOXY}-4-CHLOROBENZOIC ACID, Dipeptidyl peptidase 4 | 著者 | Longenecker, K.L, Fry, E.H, Lake, M.R, Solomon, L.R, Pei, Z, Li, X. | 登録日 | 2006-02-23 | 公開日 | 2006-07-04 | 最終更新日 | 2017-10-18 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors. J.Med.Chem., 49, 2006
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2GBO
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2GYQ
| YcfI, a putative structural protein from Rhodopseudomonas palustris. | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, FE (III) ION, ... | 著者 | Osipiuk, J, Evdokimova, E, Kudritska, M, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2006-05-09 | 公開日 | 2006-06-13 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | X-ray crystal structure of YcfI protein, a putative structural protein from Rhodopseudomonas palustris. To be Published
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2G2C
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2G1T
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2GKP
| Protein of Unknown Function NMB0488 from Neisseria meningitidis | 分子名称: | 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, SODIUM ION, ... | 著者 | Osipiuk, J, Volkart, L, Bargassa, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2006-04-03 | 公開日 | 2006-05-02 | 最終更新日 | 2021-03-10 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | X-ray crystal structure of hypothetical protein NMB0488 from Neisseria meningitidis. To be Published
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2HDP
| Solution Structure of Hdm2 RING Finger Domain | 分子名称: | Ubiquitin-protein ligase E3 Mdm2, ZINC ION | 著者 | Kostic, M, Matt, T, Yamout-Martinez, M, Dyson, H.J, Wright, P.E. | 登録日 | 2006-06-20 | 公開日 | 2006-11-21 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53. J.Mol.Biol., 363, 2006
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2GU3
| YpmB protein from Bacillus subtilis | 分子名称: | NICKEL (II) ION, YpmB protein | 著者 | Osipiuk, J, Maltseva, N, Dementieva, I, Moy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2006-04-28 | 公開日 | 2006-05-30 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | X-ray crystal structure of YpmB protein from Bacillus subtilis. To be Published
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2HDR
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2GRX
| Crystal structure of TonB in complex with FhuA, E. coli outer membrane receptor for ferrichrome | 分子名称: | 2-AMINO-VINYL-PHOSPHATE, 3-HYDROXY-TETRADECANOIC ACID, 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-[L-glycero-alpha-D-manno-heptopyranose-(1-5)]3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-6)-2-amino-2,3-dideoxy-alpha-D-glucoyranose-(1-6)-2-amino-2,3-dideoxy-alpha-D-glucoyranose, ... | 著者 | Pawelek, P.D, Allaire, M, Coulton, J.W. | 登録日 | 2006-04-25 | 公開日 | 2006-06-13 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structure of TonB in complex with FhuA, E. coli outer membrane receptor. Science, 312, 2006
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4UV7
| The complex structure of extracellular domain of EGFR and GC1118A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, EPIDERMAL GROWTH FACTOR RECEPTOR, ... | 著者 | Yoo, J.H, Cho, H.S. | 登録日 | 2014-08-05 | 公開日 | 2015-10-14 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Gc1118, an Anti-Egfr Antibody with a Distinct Binding Epitope and Superior Inhibitory Activity Against High-Affinity Egfr Ligands. Mol.Cancer Ther., 15, 2016
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2J6W
| R164N mutant of the RUNX1 Runt domain | 分子名称: | CHLORIDE ION, RUNT-RELATED TRANSCRIPTION FACTOR 1 | 著者 | Grembecka, J, Zhe, L, Lukasik, S.M, Liu, Y, Bielnicka, I, Bushweller, J.H, Speck, N.A. | 登録日 | 2006-10-04 | 公開日 | 2007-10-09 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A Mutation in the S-Switch Region of the Runt Domain Alters the Dynamics of an Allosteric Network Responsible for Cbfbeta Regulation. J.Mol.Biol., 364, 2006
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4X47
| Crystal structure of the intramolecular trans-sialidase from Ruminococcus gnavus in complex with Neu5Ac2en | 分子名称: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, Anhydrosialidase, PHOSPHATE ION | 著者 | Owen, C.D, Tailford, L.E, Taylor, G.L, Juge, N. | 登録日 | 2014-12-02 | 公開日 | 2015-07-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation. Nat Commun, 6, 2015
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4L7I
| Crystal structure of S-Adenosylmethionine synthase from Sulfolobus solfataricus complexed with SAM and PPi | 分子名称: | DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Wang, F, Hurley, K.A, Helmich, K.E, Singh, S, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2013-06-13 | 公開日 | 2013-07-03 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.189 Å) | 主引用文献 | Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus. Febs J., 281, 2014
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9BNQ
| N-(4-(isothiocyanatomethyl)phenyl)methanesulfonamide complexed with Macrophage Migration Inhibitory Factor | 分子名称: | ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, N-{[4-(methanesulfonamido)phenyl]methyl}methanethioamide, ... | 著者 | Fellner, M, Rutledge, M.T, Putha, L, Kok, L.K, Gamble, A.B, Wilbanks, S.M, Vernall, A.J, Tyndall, J.D.A. | 登録日 | 2024-05-02 | 公開日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | 主引用文献 | Covalent isothiocyanate inhibitors of macrophage migration inhibitory factor as potential colorectal cancer treatments. Chemmedchem, 2024
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9BNR
| 4-(2-isothiocyanatoethyl)benzenesulfonamide complexed with Macrophage Migration Inhibitory Factor | 分子名称: | Macrophage migration inhibitory factor, N-[2-(4-sulfamoylphenyl)ethyl]methanethioamide, SULFATE ION | 著者 | Fellner, M, Rutledge, M.T, Putha, L, Kok, L.K, Gamble, A.B, Wilbanks, S.M, Vernall, A.J, Tyndall, J.D.A. | 登録日 | 2024-05-02 | 公開日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Covalent isothiocyanate inhibitors of macrophage migration inhibitory factor as potential colorectal cancer treatments. Chemmedchem, 2024
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4X6K
| Crystal structure of the intramolecular trans-sialidase from Ruminococcus gnavus in complex with Siastatin B | 分子名称: | (2S,3R,4S,5S)-2-(acetylamino)-5-carboxy-3,4-dihydroxypiperidinium, ACETYL GROUP, Anhydrosialidase | 著者 | Owen, C.D, Tailford, L.E, Taylor, G.L, Juge, N. | 登録日 | 2014-12-08 | 公開日 | 2015-07-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation. Nat Commun, 6, 2015
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2JG7
| Crystal structure of Seabream Antiquitin and Elucidation of its substrate specificity | 分子名称: | ANTIQUITIN, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Tang, W.K, Wong, K.B, Cha, S.S, Lee, H.S, Cheng, C.H.K, Fong, W.P. | 登録日 | 2007-02-09 | 公開日 | 2008-05-13 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | The Crystal Structure of Seabream Antiquitin Reveals the Structural Basis of its Substrate Specificity. FEBS Lett., 582, 2008
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4LRE
| Phosphopentomutase soaked with 2,3-dideoxyribose 5-phosphate | 分子名称: | 2,3-dideoxy-5-O-phosphono-alpha-D-ribofuranose, MANGANESE (II) ION, Phosphopentomutase | 著者 | Birmingham, W.A, Starbird, C.A, Panosian, T.D, Nannemann, D.P, Iverson, T.M, Bachmann, B.O. | 登録日 | 2013-07-19 | 公開日 | 2013-07-31 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Bioretrosynthetic construction of a didanosine biosynthetic pathway. Nat.Chem.Biol., 10, 2014
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2JH5
| Human Thrombin Hirugen Inhibitor complex | 分子名称: | 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHENESULFONAMIDE, CALCIUM ION, HIRUDIN IIIA, ... | 著者 | Senger, S, Chan, C, Convery, M.A, Hubbard, J.A, Young, R.J, Shah, G.P, Watson, N.S. | 登録日 | 2007-02-20 | 公開日 | 2007-05-08 | 最終更新日 | 2017-06-28 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Sulfonamide-Related Conformational Effects and Their Importance in Structure-Based Design. Bioorg.Med.Chem.Lett., 17, 2007
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2JH0
| Human Thrombin Hirugen Inhibitor complex | 分子名称: | (2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE, CALCIUM ION, HIRUDIN IIIA, ... | 著者 | Senger, S, Chan, C, Convery, M.A, Hubbard, J.A, Young, R.J, Shah, G.P, Watson, N.S. | 登録日 | 2007-02-19 | 公開日 | 2007-05-08 | 最終更新日 | 2013-08-07 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Sulfonamide-Related Conformational Effects and Their Importance in Structure-Based Design. Bioorg.Med.Chem.Lett., 17, 2007
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