2JH5

Human Thrombin Hirugen Inhibitor complex

Summary for 2JH5

Related2JH0 2JH6
DescriptorTHROMBIN LIGHT CHAIN, THROMBIN HEAVY CHAIN, HIRUDIN IIIA, ... (7 entities in total)
Functional Keywordsglycoprotein, serine protease, kringle, zymogen, thrombin, protease, disease mutation, blood coagulation, gamma-carboxyglutamic acid, protease inhibitor, serine protease inhibitor, sulfation, acute phase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
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Cellular locationSecreted, extracellular space P00734 P00734
Secreted P28507
Total number of polymer chains3
Total molecular weight35751.18
Authors
Senger, S.,Chan, C.,Convery, M.A.,Hubbard, J.A.,Young, R.J.,Shah, G.P.,Watson, N.S. (deposition date: 2007-02-20, release date: 2007-05-08, Last modification date: 2017-06-28)
Primary citation
Senger, S.,Chan, C.,Convery, M.A.,Hubbard, J.A.,Shah, G.P.,Watson, N.S.,Young, R.J.
Sulfonamide-Related Conformational Effects and Their Importance in Structure-Based Design.
Bioorg.Med.Chem.Lett., 17:2931-, 2007
PubMed: 17336062 (PDB entries with the same primary citation)
DOI: 10.1016/J.BMCL.2007.02.034
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.224500.8%1.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report