2J6W
R164N mutant of the RUNX1 Runt domain
Summary for 2J6W
Entry DOI | 10.2210/pdb2j6w/pdb |
Related | 1EAN 1EAO 1EAQ 1HJB 1HJC 1IO4 |
Descriptor | RUNT-RELATED TRANSCRIPTION FACTOR 1, CHLORIDE ION (3 entities in total) |
Functional Keywords | transcription factor, transcription/dna, chloride binding, acute myeloid leukemia, transcription regulation, transcription, nuclear protein, phosphorylation, aml, runx1, ig fold, runt domain, dna-binding |
Biological source | MUS MUSCULUS (MOUSE) |
Cellular location | Nucleus: Q03347 |
Total number of polymer chains | 2 |
Total formula weight | 31102.73 |
Authors | Grembecka, J.,Zhe, L.,Lukasik, S.M.,Liu, Y.,Bielnicka, I.,Bushweller, J.H.,Speck, N.A. (deposition date: 2006-10-04, release date: 2007-10-09, Last modification date: 2023-12-13) |
Primary citation | Li, Z.,Lukasik, S.M.,Liu, Y.,Grembecka, J.,Bielnicka, I.,Bushweller, J.H.,Speck, N.A. A Mutation in the S-Switch Region of the Runt Domain Alters the Dynamics of an Allosteric Network Responsible for Cbfbeta Regulation. J.Mol.Biol., 364:1073-, 2006 Cited by PubMed: 17059830DOI: 10.1016/J.JMB.2006.10.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report