2J6W
R164N mutant of the RUNX1 Runt domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | RUNT-RELATED TRANSCRIPTION FACTOR 1 | polymer | 140 | 15480.5 | 2 | UniProt (Q03347) Pfam (PF00853) In PDB | MUS MUSCULUS (MOUSE) | CORE-BINDING FACTOR ALPHA 2 SUBUNIT, CBF-ALPHA 2, ACUTE MYELOID LEUKEMIA 1 PROTEIN, ONCOGENE AML-1, POLYOMAVIRUS ENHANCER-BINDING PROTEIN 2 ALPHA B SUBUNIT, PEBP2-ALPHA B, PEA2-ALPHA B, SL3-3 ENHANCER FACTOR 1 ALPHA B SUBUNIT, SL3/AKV CORE-BINDING FACTOR ALPHA B SUBUNIT, R164N MUTANT OF THE RUNX1 RUNT DOMAIN |
| 2 | A, B | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 3 | water | water | 18.0 | 49 | Chemie (HOH) |
Sequence modifications
A, B: 46 - 185 (UniProt: Q03347)
| PDB | External Database | Details |
|---|---|---|
| Ser 72 | Cys 72 | engineered mutation |
| Ser 81 | Cys 81 | engineered mutation |
| Asn 164 | Arg 164 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30960.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 141.8 | |
| All* | Total formula weight | 31102.7 |
