4UV7

The complex structure of extracellular domain of EGFR and GC1118A

Summary for 4UV7

DescriptorEPIDERMAL GROWTH FACTOR RECEPTOR, GC1118A, N-ACETYL-D-GLUCOSAMINE, ... (6 entities in total)
Functional Keywordstransferase, receptor tyrosine kinase, antibody
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted P00533
Total number of polymer chains3
Total molecular weight118591.47
Authors
Yoo, J.H.,Cho, H.S. (deposition date: 2014-08-05, release date: 2015-10-14, Last modification date: 2016-03-02)
Primary citation
Lim, Y.,Yoo, J.,Kim, M.S.,Hur, M.,Lee, E.H.,Hur, H.S.,Lee, J.C.,Lee, S.N.,Park, T.W.,Lee, K.,Chang, K.H.,Kim, K.,Kang, Y.,Hong, K.W.,Kim, S.H.,Kim, Y.G.,Yoon, Y.,Nam, D.H.,Yang, H.,Kim, D.G.,Cho, H.S.,Won, J.
Gc1118, an Anti-Egfr Antibody with a Distinct Binding Epitope and Superior Inhibitory Activity Against High-Affinity Egfr Ligands.
Mol.Cancer Ther., 15:251-, 2016
PubMed: 26586721 (PDB entries with the same primary citation)
DOI: 10.1158/1535-7163.MCT-15-0679
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.251302.7%10.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4uv7
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Molmil generated image of 4uv7
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Molmil generated image of 4uv7
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