4UV7
The complex structure of extracellular domain of EGFR and GC1118A
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR197-HIS203 | |
| H | TYR203-HIS209 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 620 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU1-SER621 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:21487020 |
| Chain | Residue | Details |
| A | SER205 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; atypical; partial => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1MOX, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3QWQ |
| Chain | Residue | Details |
| A | ASN32 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; atypical => ECO:0000269|PubMed:20837704, ECO:0007744|PDB:3NJP |
| Chain | Residue | Details |
| A | ASN49 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:8962717 |
| Chain | Residue | Details |
| A | ASN104 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:3NJP |
| Chain | Residue | Details |
| A | ASN151 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1MOX, ECO:0007744|PDB:3NJP |
| Chain | Residue | Details |
| A | ASN172 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1MOX, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UIP, ECO:0007744|PDB:4UV7 |
| Chain | Residue | Details |
| A | ASN328 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UV7 |
| Chain | Residue | Details |
| A | ASN337 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP |
| Chain | Residue | Details |
| A | ASN389 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UIP, ECO:0007744|PDB:4UV7 |
| Chain | Residue | Details |
| A | ASN420 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:25922362, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UIP, ECO:0007744|PDB:4UV7 |
| Chain | Residue | Details |
| A | ASN504 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:19159218, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9 |
| Chain | Residue | Details |
| A | ASN544 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9 |
| Chain | Residue | Details |
| A | ASN579 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000305|PubMed:12731890 |
| Chain | Residue | Details |
| A | ASN599 |
