4X6K

Crystal structure of the intramolecular trans-sialidase from Ruminococcus gnavus in complex with Siastatin B

Summary for 4X6K

Entry DOI	10.2210/pdb4x6k/pdb
Descriptor	Anhydrosialidase, ACETYL GROUP, (2S,3R,4S,5S)-2-(acetylamino)-5-carboxy-3,4-dihydroxypiperidinium, ... (4 entities in total)
Functional Keywords	intramolecular, trans-sialidase, sialidase, neuraminidase, siastatin b, inhibitor, complex, hydrolase, anhydrosialidase
Biological source	Ruminococcus gnavus CC55_001C
Total number of polymer chains	1
Total formula weight	53996.55
Authors	Owen, C.D.,Tailford, L.E.,Taylor, G.L.,Juge, N. (deposition date: 2014-12-08, release date: 2015-07-22, Last modification date: 2024-01-10)
Primary citation	Tailford, L.E.,Owen, C.D.,Walshaw, J.,Crost, E.H.,Hardy-Goddard, J.,Le Gall, G.,de Vos, W.M.,Taylor, G.L.,Juge, N. Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation. Nat Commun, 6:7624-7624, 2015 Cited by PubMed: 26154892 DOI: 10.1038/ncomms8624 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation