PDB: 340 件ウェブページステータス検索Chemie searchBIRD

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3RQ4	Crystal structure of suppressor of variegation 4-20 homolog 2 分子名称: 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase SUV420H2, S-ADENOSYLMETHIONINE, ... 著者 Dong, A, Zeng, H, Tempel, W, Loppnau, P, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) 登録日 2011-04-27 公開日 2011-06-01 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2. Febs Lett., 587, 2013
3RJW	Crystal structure of histone lysine methyltransferase g9a with an inhibitor 分子名称: 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)piperidin-4-yl]-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Dong, A, Wasney, G.A, Tempel, W, Liu, F, Barsyte, D, Allali-Hassani, A, Chen, X, Chau, I, Hajian, T, Senisterra, G, Chavda, N, Arora, K, Siarheyeva, A, Kireev, D.B, Herold, J.M, Bochkarev, A, Bountra, C, Weigelt, J, Edwards, A.M, Frye, S.V, Arrowsmith, C.H, Brown, P.J, Jin, J, Vedadi, M, Structural Genomics Consortium (SGC) 登録日 2011-04-15 公開日 2011-05-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat.Chem.Biol., 7, 2011
3RIB	Human lysine methyltransferase Smyd2 in complex with AdoHcy 分子名称: N-lysine methyltransferase SMYD2, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Xu, S, Zhang, T, Zhong, C, Ding, J. 登録日 2011-04-13 公開日 2011-07-20 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Structure of human lysine methyltransferase Smyd2 reveals insights into the substrate divergence in Smyd proteins J Mol Cell Biol, 3, 2011
3RC0	Human SETD6 in complex with RelA Lys310 peptide 分子名称: 1,2-ETHANEDIOL, N-lysine methyltransferase SETD6, S-ADENOSYLMETHIONINE, ... 著者 Chang, Y, Levy, D, Horton, J.R, Peng, J, Zhang, X, Gozani, O, Cheng, X. 登録日 2011-03-30 公開日 2011-05-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling. Nucleic Acids Res., 39, 2011
3QXY	Human SETD6 in complex with RelA Lys310 分子名称: 1,2-ETHANEDIOL, N-lysine methyltransferase SETD6, S-ADENOSYLMETHIONINE, ... 著者 Chang, Y, Levy, D, Horton, J.R, Peng, J, Zhang, X, Gozani, O, Cheng, X. 登録日 2011-03-02 公開日 2011-05-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling. Nucleic Acids Res., 39, 2011
3QWW	Crystal structure of histone lysine methyltransferase SmyD2 in complex with the methyltransferase inhibitor sinefungin 分子名称: SET and MYND domain-containing protein 2, SINEFUNGIN, ZINC ION 著者 Jiang, Y, Sirinupong, N, Brunzelle, J, Yang, Z. 登録日 2011-02-28 公開日 2011-07-06 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structures of histone and p53 methyltransferase SmyD2 reveal a conformational flexibility of the autoinhibitory C-terminal domain. Plos One, 6, 2011
3QWV	Crystal structure of histone lysine methyltransferase SmyD2 in complex with the cofactor product AdoHcy 分子名称: S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 2, ZINC ION 著者 Jiang, Y, Sirinupong, N, Brunzelle, J, Yang, Z. 登録日 2011-02-28 公開日 2011-07-06 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Crystal structures of histone and p53 methyltransferase SmyD2 reveal a conformational flexibility of the autoinhibitory C-terminal domain. Plos One, 6, 2011
3QWP	Crystal structure of SET and MYND domain containing 3; Zinc finger MYND domain-containing protein 1 分子名称: GLYCEROL, S-ADENOSYLMETHIONINE, SET and MYND domain-containing protein 3, ... 著者 Dong, A, Dombrovski, L, Li, Y, Wernimont, A, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) 登録日 2011-02-28 公開日 2011-04-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 The Crystal Structure of human Histone-lysine N-methyltransferase SMYD3 To be Published
3PDN	Crystal structure of SmyD3 in complex with methyltransferase inhibitor sinefungin 分子名称: GLYCEROL, MAGNESIUM ION, SET and MYND domain-containing protein 3, ... 著者 Sirinupong, N, Brunzelle, J, Yang, Z. 登録日 2010-10-23 公開日 2010-11-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Insights into the Autoinhibition and Posttranslational Activation of Histone Methyltransferase SmyD3. J.Mol.Biol., 406, 2011
3OXL	Human lysine methyltransferase Smyd3 in complex with AdoHcy (Form II) 分子名称: S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 3, ZINC ION 著者 Xu, S, Wu, J, Sun, B, Zhong, C, Ding, J. 登録日 2010-09-21 公開日 2011-02-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding Nucleic Acids Res., 39, 2011
3OXG	human lysine methyltransferase Smyd3 in complex with AdoHcy (Form III) 分子名称: S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 3, ZINC ION 著者 Xu, S, Wu, J, Sun, B, Zhong, C, Ding, J. 登録日 2010-09-21 公開日 2011-02-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.41 Å) 主引用文献 Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding. Nucleic Acids Res., 39, 2011
3OXF	Human lysine methyltransferase Smyd3 in complex with AdoHcy (Form I) 分子名称: S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 3, ZINC ION 著者 Xu, S, Wu, J, Sun, B, Zhong, C, Ding, J. 登録日 2010-09-21 公開日 2011-02-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding. Nucleic Acids Res., 39, 2011
3OS5	SET7/9-Dnmt1 K142me1 complex 分子名称: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Dnmt1, ... 著者 Esteve, P.-O, Chang, Y, Samaranayake, M, Upadhyay, A.K, Horton, J.R, Feehery, G.R, Cheng, X, Pradhan, S. 登録日 2010-09-08 公開日 2010-12-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability. Nat.Struct.Mol.Biol., 18, 2011
3OPE	Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase 分子名称: Probable histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ZINC ION 著者 An, S, Song, J. 登録日 2010-08-31 公開日 2011-01-12 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism J.Biol.Chem., 286, 2011
3OOI	Crystal Structure of Human Histone-Lysine N-methyltransferase NSD1 SET domain in Complex with S-adenosyl-L-methionine 分子名称: Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, S-ADENOSYLMETHIONINE, ... 著者 Qiao, Q, Wang, M, Xu, R.M. 登録日 2010-08-31 公開日 2010-12-22 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation J.Biol.Chem., 286, 2010
3N71	Crystal structure of cardiac specific histone methyltransferase SmyD1 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, Histone lysine methyltransferase SmyD1, ... 著者 Sirinupong, N, Yang, Z. 登録日 2010-05-26 公開日 2010-10-13 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of Cardiac-specific Histone Methyltransferase SmyD1 Reveals Unusual Active Site Architecture. J.Biol.Chem., 285, 2010
3MO2	human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67 分子名称: 7-[(5-aminopentyl)oxy]-N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ... 著者 Chang, Y, Horton, J.R, Cheng, X. 登録日 2010-04-22 公開日 2010-06-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J.Mol.Biol., 400, 2010
3MO5	Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72 分子名称: 7-[(5-aminopentyl)oxy]-N~4~-[1-(5-aminopentyl)piperidin-4-yl]-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ... 著者 Chang, Y, Horton, J.R, Cheng, X. 登録日 2010-04-22 公開日 2010-06-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J.Mol.Biol., 400, 2010
3MO0	Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E11 分子名称: 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ... 著者 Chang, Y, Horton, J.R, Cheng, X. 登録日 2010-04-22 公開日 2010-06-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J.Mol.Biol., 400, 2010
3MEK	Crystal Structure of Human Histone-Lysine N-methyltransferase SMYD3 in Complex with S-adenosyl-L-methionine 分子名称: S-ADENOSYLMETHIONINE, SET and MYND domain-containing protein 3, ZINC ION 著者 Lam, R, Dombrovski, L, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Wu, H, Structural Genomics Consortium (SGC) 登録日 2010-03-31 公開日 2010-04-14 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of Human Histone-Lysine N-methyltransferase SMYD3 in Complex with S-adenosyl-L-methionine To be Published
3M57	SET7/9 Y245A in complex with TAF10 peptide and AdoHcy 分子名称: GLYCEROL, Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. 登録日 2010-03-12 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
3M54	SET7/9 Y305F in complex with TAF10 peptide and AdoHcy 分子名称: Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, TAF10 peptide 著者 Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. 登録日 2010-03-12 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
3M56	SET7/9 Y305F in complex with TAF10-K189me2 peptide and AdoHcy 分子名称: Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, TAF10-K189me2 PEPTIDE 著者 Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. 登録日 2010-03-12 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
3M5A	SET7/9 Y245A in complex with TAF10-K189me3 peptide and AdoHcy 分子名称: COBALT (II) ION, GLYCEROL, Histone-lysine N-methyltransferase SETD7, ... 著者 Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. 登録日 2010-03-12 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
3M58	SET7/9 Y245A in complex with TAF10-K189me1 peptide and AdoHcy 分子名称: Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. 登録日 2010-03-12 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010

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