3HD0
| Crystal structure of Tm1865, an Endonuclease V from Thermotoga Maritima | 分子名称: | Endonuclease V | 著者 | Utepbergenov, D, Cooper, D.R, Derewenda, U, Derewenda, Z.S, Integrated Center for Structure and Function Innovation (ISFI) | 登録日 | 2009-05-06 | 公開日 | 2009-07-14 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of Tm1865, an Endonuclease V from Thermotoga Maritima To be Published
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6ES7
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7WUB
| Cryo-EM structure of dodecamer P97 | 分子名称: | 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | 著者 | Liu, S, Wang, T. | 登録日 | 2022-02-08 | 公開日 | 2022-03-23 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Cryo-EM structure of dodecamer P97 at 2.99 Angstroms resolution To Be Published
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4FZV
| Crystal structure of the human MTERF4:NSUN4:SAM ternary complex | 分子名称: | 1,2-ETHANEDIOL, FORMIC ACID, Putative methyltransferase NSUN4, ... | 著者 | Guja, K.E, Yakubovskaya, E, Mejia, E, Castano, S, Hambardjieva, E, Choi, W.S, Garcia-Diaz, M. | 登録日 | 2012-07-08 | 公開日 | 2012-10-03 | 最終更新日 | 2012-11-28 | 実験手法 | X-RAY DIFFRACTION (1.9996 Å) | 主引用文献 | Structure of the Essential MTERF4:NSUN4 Protein Complex Reveals How an MTERF Protein Collaborates to Facilitate rRNA Modification. Structure, 20, 2012
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6ES6
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2EO0
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3GA2
| Crystal structure of the Endonuclease_V (BSU36170) from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR624 | 分子名称: | Endonuclease V | 著者 | Forouhar, F, Abashidze, M, Hussain, M, Seetharaman, J, Janjua, H, Fang, Y, Xiao, R, Cunningham, K, Ma, L.-C, Owens, L, Wang, D, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2009-02-16 | 公開日 | 2009-02-24 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of the Endonuclease_V (BSU36170) from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR624 To be Published
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4DQM
| Revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity | 分子名称: | (5S)-4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,7-dien-1-yl]-5-hydroxyfuran-2(5H)-one, Nuclear receptor coactivator 1, Retinoic acid receptor alpha | 著者 | Wang, S, Wang, Z, Lin, S, Zheng, W, Wang, R, Jin, S, Chen, J, Jin, L, Li, Y. | 登録日 | 2012-02-16 | 公開日 | 2012-10-03 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells. Biochem.J., 446, 2012
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6ES5
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6AOC
| Crystal Structure of an N-Hydroxythienopyrimidine-2,4-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase | 分子名称: | 1,2-ETHANEDIOL, 6-benzyl-3-hydroxythieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, MANGANESE (II) ION, ... | 著者 | Kirby, K.A, Sarafianos, S.G. | 登録日 | 2017-08-15 | 公開日 | 2018-08-08 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H. Eur J Med Chem, 141, 2017
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2XK9
| Structural analysis of checkpoint kinase 2 (Chk2) in complex with inhibitor PV1533 | 分子名称: | CHECKPOINT KINASE 2, N-{4-[(1E)-N-(N-hydroxycarbamimidoyl)ethanehydrazonoyl]phenyl}-7-nitro-1H-indole-2-carboxamide | 著者 | Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C, Shoemaker, R.H, Pommier, Y, Waugh, D.S. | 登録日 | 2010-07-07 | 公開日 | 2011-07-20 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy. J.Struct.Biol., 176, 2011
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6IAM
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2JK3
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5OGB
| Human Cellular Retinoic Acid Binding Protein II (CRABPII) with bound synthetic retinoid DC360. | 分子名称: | 4-[2-(4,4-dimethyl-1-propan-2-yl-quinolin-6-yl)ethynyl]benzoic acid, Cellular retinoic acid-binding protein 2 | 著者 | Chisholm, D, Tomlinson, C, Whiting, A, Pohl, E. | 登録日 | 2017-07-12 | 公開日 | 2018-10-24 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Fluorescent Retinoic Acid Analogues as Probes for Biochemical and Intracellular Characterization of Retinoid Signaling Pathways. Acs Chem.Biol., 14, 2019
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3BYH
| Model of actin-fimbrin ABD2 complex | 分子名称: | Actin, fimbrin ABD2 | 著者 | Galkin, V.E, Orlova, A, Cherepanova, O, Lebart, M.C, Egelman, E.H. | 登録日 | 2008-01-16 | 公開日 | 2008-02-19 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (12 Å) | 主引用文献 | High-resolution cryo-EM structure of the F-actin-fimbrin/plastin ABD2 complex. Proc.Natl.Acad.Sci.Usa, 105, 2008
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7X4U
| Crystal structure of ERK2 with an allosteric inhibitor 2 | 分子名称: | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... | 著者 | Yoshida, M, Kinoshita, T. | 登録日 | 2022-03-03 | 公開日 | 2023-03-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Structural basis for producing allosteric ERK2 inhibitors To Be Published
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3D55
| Crystal structure of M. tuberculosis YefM antitoxin | 分子名称: | SULFATE ION, Uncharacterized protein Rv3357/MT3465 | 著者 | Kumar, P, Issac, B, Dodson, E.J, Turkenberg, J.P, Mande, S.C. | 登録日 | 2008-05-15 | 公開日 | 2008-12-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Crystal structure of Mycobacterium tuberculosis YefM antitoxin reveals that it is not an intrinsically unstructured protein J.Mol.Biol., 383, 2008
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7XC1
| Crystal structure of ERK2 with an allosteric inhibitor 3 | 分子名称: | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... | 著者 | Yoshida, M, Kinoshita, T. | 登録日 | 2022-03-22 | 公開日 | 2023-03-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Structural basis for ERK2 allosteric inhibitors. To Be Published
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4DQ2
| Structure of staphylococcus aureus biotin protein ligase in complex with biotinol-5'-amp | 分子名称: | ((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL 5-((3AS,4S,6AR)-2-OXO-HEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL)PENTYL HYDROGEN PHOSPHATE, Biotin-[acetyl-CoA-carboxylase] ligase | 著者 | Wilce, M, Yap, M, Pendini, N, Soares de Costa, T, Polyak, S, Tieu, W, Booker, G, Wallace, J. | 登録日 | 2012-02-14 | 公開日 | 2012-04-18 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Selective inhibition of biotin protein ligase from Staphylococcus aureus. J.Biol.Chem., 287, 2012
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3CTO
| Crystal Structure of M. tuberculosis YefM antitoxin | 分子名称: | SULFATE ION, Uncharacterized protein Rv3357/MT3465 | 著者 | Kumar, P, Issac, B, Dodson, E.J, Turkenberg, J.P, Mande, S.C. | 登録日 | 2008-04-14 | 公開日 | 2008-12-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of Mycobacterium tuberculosis YefM antitoxin reveals that it is not an intrinsically unstructured protein J.Mol.Biol., 383, 2008
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2Z1I
| Crystal structure of E.coli RNase HI surface charged mutant(Q4R/T40E/Q72H/Q76K/Q80E/T92K/Q105K/Q113R/Q115K) | 分子名称: | Ribonuclease HI | 著者 | You, D.J, Fukuchi, S, Nishikawa, K, Koga, Y, Takano, K, Kanaya, S. | 登録日 | 2007-05-08 | 公開日 | 2007-11-13 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Protein Thermostabilization Requires a Fine-tuned Placement of Surface-charged Residues J.Biochem.(Tokyo), 142, 2007
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2Z1J
| Crystal structure of E.coli RNase HI surface charged mutant(Q4R/T40E/Q72H/Q76K/Q80E/T92K/Q105K/Q113R/Q115K/N143K/T145K) | 分子名称: | Ribonuclease HI | 著者 | You, D.J, Fukuchi, S, Nishikawa, K, Koga, Y, Takano, K, Kanaya, S. | 登録日 | 2007-05-08 | 公開日 | 2007-11-13 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Protein Thermostabilization Requires a Fine-tuned Placement of Surface-charged Residues J.Biochem.(Tokyo), 142, 2007
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5QXJ
| PanDDA analysis group deposition -- Crystal Structure of ATAD2 in complex with PC578 | 分子名称: | (3aS,8S,9aS)-10-methyl-4-oxo-1,4,6,8,9,9a-hexahydro-3a,8-epiminocyclohepta[1,2-c:4,5-c']dipyrrole-2(3H)-carbaldehyde, 1,2-ETHANEDIOL, ATPase family AAA domain-containing protein 2, ... | 著者 | Snee, M, Talon, R, Fowley, D, Collins, P, Nelson, A, Arrowsmith, C.H, Bountra, C, Edwards, A, Von-Delft, F. | 登録日 | 2020-02-11 | 公開日 | 2020-04-08 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | PanDDA analysis group deposition - Bromodomain of human ATAD2 fragment screening To Be Published
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5QXI
| PanDDA analysis group deposition -- Crystal Structure of ATAD2 in complex with PC587 | 分子名称: | (4R,4aR,7aS,9R)-3,10-dimethyl-5,6,7,7a,8,9-hexahydro-4H-4a,9-epiminopyrrolo[3',4':5,6]cyclohepta[1,2-d][1,2]oxazol-4-ol, (4R,4aS,7aS,9S)-3,10-dimethyl-5,6,7,7a,8,9-hexahydro-4H-4a,9-epiminopyrrolo[3',4':5,6]cyclohepta[1,2-d][1,2]oxazol-4-ol, 1,2-ETHANEDIOL, ... | 著者 | Snee, M, Talon, R, Fowley, D, Collins, P, Nelson, A, Arrowsmith, C.H, Bountra, C, Edwards, A, Von-Delft, F. | 登録日 | 2020-02-11 | 公開日 | 2020-04-08 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | PanDDA analysis group deposition - Bromodomain of human ATAD2 fragment screening To Be Published
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5QXK
| PanDDA analysis group deposition -- Crystal Structure of ATAD2 in complex with PC581 | 分子名称: | (3aS,8S,9aS)-2-acetyl-10-methyl-2,3,6,8,9,9a-hexahydro-3a,8-epiminocyclohepta[1,2-c:4,5-c']dipyrrol-4(1H)-one, 1,2-ETHANEDIOL, ATPase family AAA domain-containing protein 2, ... | 著者 | Snee, M, Talon, R, Fowley, D, Collins, P, Nelson, A, Arrowsmith, C.H, Bountra, C, Edwards, A, Von-Delft, F. | 登録日 | 2020-02-11 | 公開日 | 2020-04-08 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | PanDDA analysis group deposition - Bromodomain of human ATAD2 fragment screening To Be Published
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