4DQ2

Structure of staphylococcus aureus biotin protein ligase in complex with biotinol-5'-amp

Summary for 4DQ2

Entry DOI	10.2210/pdb4dq2/pdb
Descriptor	Biotin-[acetyl-CoA-carboxylase] ligase, ((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL 5-((3AS,4S,6AR)-2-OXO-HEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL)PENTYL HYDROGEN PHOSPHATE (3 entities in total)
Functional Keywords	dna binding domain, metabolism, biotin, ligate, ligase
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	38443.17
Authors	Wilce, M.,Yap, M.,Pendini, N.,Soares de Costa, T.,Polyak, S.,Tieu, W.,Booker, G.,Wallace, J. (deposition date: 2012-02-14, release date: 2012-04-18, Last modification date: 2024-03-20)
Primary citation	Soares da Costa, T.P.,Tieu, W.,Yap, M.Y.,Pendini, N.R.,Polyak, S.W.,Sejer Pedersen, D.,Morona, R.,Turnidge, J.D.,Wallace, J.C.,Wilce, M.C.,Booker, G.W.,Abell, A.D. Selective inhibition of biotin protein ligase from Staphylococcus aureus. J.Biol.Chem., 287:17823-17832, 2012 Cited by PubMed: 22437830 DOI: 10.1074/jbc.M112.356576 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation