4DQM

Revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity

Summary for 4DQM

• Entry DOI: 10.2210/pdb4dqm/pdb
• Descriptor: Retinoic acid receptor alpha, Nuclear receptor coactivator 1, (5S)-4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,7-dien-1-yl]-5-hydroxyfuran-2(5H)-one, ... (4 entities in total)
• Functional Keywords: nuclear receptor transcription factor, ligand binding domain, transcription regulation, nucleus, transcription-transferase complex, transcription/transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P10276 Q15788
• Total number of polymer chains: 4
• Total formula weight: 56091.71

Authors

Wang, S.,Wang, Z.,Lin, S.,Zheng, W.,Wang, R.,Jin, S.,Chen, J.,Jin, L.,Li, Y. (deposition date: 2012-02-16, release date: 2012-10-03, Last modification date: 2017-11-15)

• Primary citation: Wang, S.,Wang, Z.,Lin, S.,Zheng, W.,Wang, R.,Jin, S.,Chen, J.,Jin, L.,Li, Y.; Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells.; Biochem.J., 446:79-87, 2012; PubMed: 22642567; DOI: 10.1042/BJ20120726

Experimental method

X-RAY DIFFRACTION (2.75 Å)