4DQM
Revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Retinoic acid receptor alpha | polymer | 234 | 26485.9 | 2 | UniProt (P10276) Pfam (PF00104) | Homo sapiens (human) | RAR-alpha, Nuclear receptor subfamily 1 group B member 1 |
| 2 | B, D (B, D) | Nuclear receptor coactivator 1 | polymer | 10 | 1173.4 | 2 | UniProt (Q15788) | Homo sapiens | NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1 |
| 3 | E, F (A, C) | (5S)-4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,7-dien-1-yl]-5-hydroxyfuran-2(5H)-one | non-polymer | 386.6 | 2 | Chemie (LUF) | |||
| 4 | G, H (A, C) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 55318.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 773.1 | |
| All* | Total formula weight | 56091.7 |
