4DQM

Revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0048384	biological_process	retinoic acid receptor signaling pathway
C	0003677	molecular_function	DNA binding
C	0004879	molecular_function	nuclear receptor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription
C	0048384	biological_process	retinoic acid receptor signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE LUF A 501

Chain	Residue
A	PHE228
A	SER287
A	GLY301
A	VAL395
A	LEU414
A	LEU231
A	SER232
A	CYS235
A	LEU266
A	LEU269
A	ILE273
A	ARG276
A	PHE286

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE LUF C 501

Chain	Residue
C	PHE228
C	LEU231
C	SER232
C	CYS235
C	LEU266
C	LEU269
C	ILE273
C	ARG276
C	PHE286
C	SER287
C	PHE302
C	VAL395
C	HOH605

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Motif: {"description":"UBR5-degron","evidences":[{"source":"PubMed","id":"37478846","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"3A9E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"20215566","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"19850744","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Motif: {"description":"LXXLL motif 7"}

Chain

Residue

Details

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