6AOC

Crystal Structure of an N-Hydroxythienopyrimidine-2,4-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase

Summary for 6AOC

Entry DOI	10.2210/pdb6aoc/pdb
Descriptor	Reverse transcriptase/ribonuclease H, p51 RT, MANGANESE (II) ION, ... (7 entities in total)
Functional Keywords	hiv-1, transferase - transferase inhibitor complex, transferase / transferase inhibitor
Biological source	Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More
Total number of polymer chains	4
Total formula weight	234444.14
Authors	Kirby, K.A.,Sarafianos, S.G. (deposition date: 2017-08-15, release date: 2018-08-08, Last modification date: 2023-10-04)
Primary citation	Kankanala, J.,Kirby, K.A.,Huber, A.D.,Casey, M.C.,Wilson, D.J.,Sarafianos, S.G.,Wang, Z. Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H. Eur J Med Chem, 141:149-161, 2017 Cited by PubMed: 29031062 DOI: 10.1016/j.ejmech.2017.09.054 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation