PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

---

4R3Z	Crystal structure of human ArgRS-GlnRS-AIMP1 complex 分子名称: Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, Arginine--tRNA ligase, cytoplasmic, ... 著者 Fu, Y, Kim, Y, Cho, Y. 登録日 2014-08-18 公開日 2014-10-08 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (4.033 Å) 主引用文献 Structure of the ArgRS-GlnRS-AIMP1 complex and its implications for mammalian translation Proc.Natl.Acad.Sci.USA, 111, 2014
3P78	P38 inhibitor-bound 分子名称: 1-{5-tert-butyl-3-[(1,1-dioxidothiomorpholin-4-yl)carbonyl]thiophen-2-yl}-3-naphthalen-2-ylurea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Moffett, K.K, Namboodiri, H. 登録日 2010-10-12 公開日 2011-10-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD). Bioorg.Med.Chem.Lett., 21, 2011
4ITF	Crystal structure of the human vitamin D receptor ligand binding domain complexed with 1alpha,25-Dihydroxy-2alpha-[2-(1H-tetrazole-1-yl)ethyl]vitamin D3 分子名称: (1R,2S,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-6-oxidanyl-heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-2-[2-(1,2,3,4-tetrazol-1-yl)ethyl]cyclohexane-1,3-diol, Vitamin D3 receptor 著者 Kakuda, S, Takimoto-Kamimura, M. 登録日 2013-01-18 公開日 2014-01-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 Synthesis of 2 alpha-heteroarylalkyl active vitamin d3 with therapeutic effect on enhancing bone mineral density in vivo ACS MED.CHEM.LETT., 4, 2013
3P7C	p38 inhibitor-bound 分子名称: 1-[5-tert-butyl-3-({4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepan-1-yl}carbonyl)thiophen-2-yl]-3-(2,3-dichlorophenyl)urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Moffett, K.K, Namboodiri, H. 登録日 2010-10-12 公開日 2011-10-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD). Bioorg.Med.Chem.Lett., 21, 2011
4RCB	Crystal structure of E Coli Hfq 分子名称: RNA-binding protein Hfq 著者 Su, J.Y. 登録日 2014-09-15 公開日 2015-09-16 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Limited proteolysis improves E.coli Hfq crystal structure resolution Chin J Biochem Mol Biol, 9, 2015
6AHD	The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, Brr2, U5 small nuclear ribonucleoprotein 200 kDa helicase, ... 著者 Zhan, X, Yan, C, Zhang, X, Shi, Y. 登録日 2018-08-17 公開日 2018-11-14 最終更新日 2021-06-30 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structures of the human pre-catalytic spliceosome and its precursor spliceosome. Cell Res., 28, 2018
1ILH	Crystal Structure of Human Pregnane X Receptor Ligand Binding Domain Bound to SR12813 分子名称: ORPHAN NUCLEAR RECEPTOR PXR, [2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER 著者 Watkins, R.E, Redinbo, M.R. 登録日 2001-05-08 公開日 2001-06-27 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science, 292, 2001
3PG3	Human p38 MAP Kinase in Complex with RL182 分子名称: 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-{4-[2-(pyridin-3-ylmethoxy)ethyl]-1,3-thiazol-2-yl}urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. 登録日 2010-10-29 公開日 2011-11-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-based design and synthesis of cell active N-pyrazole, N-thiazole urea inhibitors of the MAP kinase p38alpha To be Published
4R6L	Crystal structure of bacteriophytochrome RpBphP2 from photosynthetic bacterium R. palustris 分子名称: BILIVERDINE IX ALPHA, Bacteriophytochrome (Light-regulated signal transduction histidine kinase), PhyB1 著者 Yang, X, Stojkovic, E, Ozarowski, W, Kuk, J, Davydova, E, Moffat, K. 登録日 2014-08-25 公開日 2015-07-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.395 Å) 主引用文献 Light Signaling Mechanism of Two Tandem Bacteriophytochromes. Structure, 23, 2015
4QSR	Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) with bound MPD 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ATPase family AAA domain-containing protein 2, GLYCEROL, ... 著者 Chaikuad, A, Felletar, I, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2014-07-06 公開日 2014-07-23 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain MedChemComm, 5, 2014
4QSX	Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with 3'-deoxy thymidine 分子名称: 1,2-ETHANEDIOL, 1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione, ATPase family AAA domain-containing protein 2, ... 著者 Chaikuad, A, Felletar, I, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2014-07-06 公開日 2014-07-23 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain MedChemComm, 5, 2014
4QTT	Structure of S. cerevisiae Bud23-Trm112 complex involved in formation of m7G1575 on 18S rRNA (apo-form) 分子名称: 1,2-ETHANEDIOL, DODECAETHYLENE GLYCOL, Multifunctional methyltransferase subunit TRM112, ... 著者 Letoquart, J, Huvelle, E, Wacheul, L, Bourgeois, G, Zorbas, C, Graille, M, Heurgue-Hamard, V, Lafontaine, D.L.J. 登録日 2014-07-09 公開日 2014-12-24 最終更新日 2022-08-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes. Proc.Natl.Acad.Sci.USA, 111, 2014
7MSL	Structure of anti-CRISPR AcrIIC4 from Haemophilus parainfluenzae 分子名称: AcrIIC4, IODIDE ION 著者 Pan, C, Maxwell, K.L, Moraes, T.F. 登録日 2021-05-11 公開日 2022-03-23 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Structural and Mechanistic Insight into CRISPR-Cas9 Inhibition by Anti-CRISPR Protein AcrIIC4 Hpa. J.Mol.Biol., 434, 2022
2BAK	p38alpha MAP kinase bound to MPAQ 分子名称: Mitogen-activated protein kinase 14, N-(3-{[7-METHOXY-6-(2-PYRROLIDIN-1-YLETHOXY)QUINAZOLIN-4-YL]AMINO}-4-METHYLPHENYL)-2-MORPHOLIN-4-YLISONICOTINAMIDE 著者 Gerhardt, S, Breed, J, Pauptit, R.A, Read, J, Norman, R.A, Ward, W.H. 登録日 2005-10-14 公開日 2005-12-06 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase Biochemistry, 44, 2005
4RA2	PP2Ca 分子名称: MANGANESE (II) ION, PHOSPHATE ION, Protein phosphatase 1A 著者 Pan, C, Tang, J.Y, Xu, Y.F, Xiao, P, Liu, H.D, Wang, H.A, Wang, W.B, Meng, F.G, Yu, X, Sun, J.P. 登録日 2014-09-09 公開日 2015-05-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 The catalytic role of the M2 metal ion in PP2Ca SCI REP, 2015
2BAL	p38alpha MAP kinase bound to pyrazoloamine 分子名称: Mitogen-activated protein kinase 14, [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE 著者 Gerhardt, S, Pauptit, R.A, Read, J, Tucker, J, Norman, R.A, Breed, J. 登録日 2005-10-14 公開日 2005-12-06 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase. Biochemistry, 44, 2005
2BAJ	p38alpha bound to pyrazolourea 分子名称: 1-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2,3-dichlorophenyl)urea, Mitogen-activated protein kinase 14 著者 Gerhardt, S, Pauptit, R.A, Read, J, Breed, J, Norman, R.A, Ward, W.H. 登録日 2005-10-14 公開日 2005-12-06 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase Biochemistry, 44, 2005
2BAQ	p38alpha bound to Ro3201195 分子名称: Mitogen-activated protein kinase 14, [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE 著者 Gerhardt, S, Pauptit, R.A, Breed, J, Read, J, Tucker, J, Norman, R.A. 登録日 2005-10-14 公開日 2005-12-06 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase. Biochemistry, 44, 2005
4RER	Crystal structure of the phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex bound to AMP and cyclodextrin 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, ... 著者 Zhou, X.E, Ke, J, Li, X, Wang, L, Gu, X, de Waal, P.W, Tan, M.H.E, Wang, D, Wu, D, Xu, H.E, Melcher, K. 登録日 2014-09-23 公開日 2014-12-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (4.047 Å) 主引用文献 Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res., 25, 2015
4QVD	E.coli Hfq in complex with RNA Ads 分子名称: RNA (5'-R(*AP*AP*CP*UP*AP*AP*A)-3'), RNA-binding protein Hfq 著者 Wang, L.J, Wang, W.W, Li, F.D, Wu, J.H, Gong, Q.G, Shi, Y.Y. 登録日 2014-07-14 公開日 2015-05-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.972 Å) 主引用文献 Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq Nucleic Acids Res., 43, 2015
4RCC	Crystal structure of E Coli Hfq 分子名称: RNA-binding protein Hfq 著者 Su, J.Y. 登録日 2014-09-15 公開日 2015-09-16 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.981 Å) 主引用文献 Limited proteolysis improves E.coli Hfq crystal structure resolution Chin J Biochem Mol Biol, 9, 2015
4NI9	Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer (SOMAMER SL1025), FORM 2 分子名称: Interleukin-6, SODIUM ION, SOMAmer SL1025 著者 Davies, D, Edwards, T, Gelinas, A, Jarvis, T, Clifton, M.C. 登録日 2013-11-05 公開日 2014-01-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Crystal structure of interleukin-6 in complex with a modified nucleic Acid ligand. J.Biol.Chem., 289, 2014
4NI7	Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer (SOMAMER SL1025) 分子名称: Interleukin-6, SODIUM ION, SOMAmer SL1025 著者 Davies, D, Edwards, T, Gelinas, A, Jarvis, T, Clifton, M.C. 登録日 2013-11-05 公開日 2014-01-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of interleukin-6 in complex with a modified nucleic Acid ligand. J.Biol.Chem., 289, 2014
4REW	Crystal structure of the non-phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Zhou, X.E, Ke, J, Li, X, Wang, L, Gu, X, de Waal, P.W, Tan, M.H.E, Wang, D, Wu, D, Xu, H.E, Melcher, K. 登録日 2014-09-24 公開日 2014-12-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (4.58 Å) 主引用文献 Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res., 25, 2015
3HLL	Crystal Structure of Human p38alpha complexed with PH-797804 分子名称: 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, 3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl}-N,4-dimethylbenzamide, HYPOPHOSPHITE, ... 著者 Shieh, H.-S, Williams, J.M, Stegeman, R.A, Kurumbail, R.G. 登録日 2009-05-27 公開日 2009-07-14 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804. Biochemistry, 48, 2009

<1158115911601161116211631164116511661167116811691170117111721173>