4NI9

Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer (SOMAMER SL1025), FORM 2

Summary for 4NI9

• Entry DOI: 10.2210/pdb4ni9/pdb
• Related: 4NI7
• Descriptor: SOMAmer SL1025, Interleukin-6, SODIUM ION, ... (4 entities in total)
• Functional Keywords: selex, somamer, cytokine-dna complex, cytokine/dna
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P05231
• Total number of polymer chains: 4
• Total formula weight: 65126.01

Authors

Davies, D.,Edwards, T.,Gelinas, A.,Jarvis, T.,Clifton, M.C. (deposition date: 2013-11-05, release date: 2014-01-22, Last modification date: 2024-04-03)

• Primary citation: Gelinas, A.D.,Davies, D.R.,Edwards, T.E.,Rohloff, J.C.,Carter, J.D.,Zhang, C.,Gupta, S.,Ishikawa, Y.,Hirota, M.,Nakaishi, Y.,Jarvis, T.C.,Janjic, N.; Crystal structure of interleukin-6 in complex with a modified nucleic Acid ligand.; J.Biol.Chem., 289:8720-8734, 2014; PubMed: 24415767; DOI: 10.1074/jbc.M113.532697

Experimental method

X-RAY DIFFRACTION (2.55 Å)