4NI9

Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer (SOMAMER SL1025), FORM 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005138	molecular_function	interleukin-6 receptor binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006955	biological_process	immune response
A	0030154	biological_process	cell differentiation
C	0005125	molecular_function	cytokine activity
C	0005138	molecular_function	interleukin-6 receptor binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006955	biological_process	immune response
C	0030154	biological_process	cell differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA B 101

Chain	Residue
B	DG2
B	DA4
B	DG5
B	DG10
B	DG11
B	DG31
B	DG32

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 102

Chain	Residue
B	UPE9
B	DG10
B	DG32
B	DG1
B	OMG6

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Functional Information from PROSITE/UniProt

site_id	PS00254
Number of Residues	26
Details	INTERLEUKIN_6 Interleukin-6 / G-CSF / MGF signature. CfqsgfneetClvkiitGLleFevyL

Chain	Residue	Details
A	CYS73-LEU98

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039

Chain	Residue	Details
A	SER53
C	SER53

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1883960

Chain	Residue	Details
A	ASN45
C	ASN45

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