The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution

This is a large structure.

Summary for 6AHD

EMDB information9624
DescriptorPre-mRNA-processing-splicing factor 8, U4snRNA, U5snRNA, ... (52 entities in total)
Functional Keywordsspliceosome, splicing
Biological sourceHomo sapiens (Human)
Total number of polymer chains63
Total molecular weight2671164.68
Zhan, X.,Yan, C.,Zhang, X.,Shi, Y. (deposition date: 2018-08-17, release date: 2018-11-14, Last modification date: 2019-11-06)
Primary citation
Zhan, X.,Yan, C.,Zhang, X.,Lei, J.,Shi, Y.
Structures of the human pre-catalytic spliceosome and its precursor spliceosome.
Cell Res., 28:1129-1140, 2018
PubMed: 30315277 (PDB entries with the same primary citation)
DOI: 10.1038/s41422-018-0094-7
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone14 0.9% 3.2% 0.46MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation reportDownload