6AHD

The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000398	biological_process	mRNA splicing, via spliceosome
0	0001527	cellular_component	microfibril
0	0003723	molecular_function	RNA binding
0	0005515	molecular_function	protein binding
0	0005634	cellular_component	nucleus
0	0005654	cellular_component	nucleoplasm
0	0005681	cellular_component	spliceosomal complex
0	0005684	cellular_component	U2-type spliceosomal complex
0	0005813	cellular_component	centrosome
0	0006397	biological_process	mRNA processing
0	0008380	biological_process	RNA splicing
0	0071005	cellular_component	U2-type precatalytic spliceosome
1	0000245	biological_process	spliceosomal complex assembly
1	0000375	biological_process	RNA splicing, via transesterification reactions
1	0000398	biological_process	mRNA splicing, via spliceosome
1	0003723	molecular_function	RNA binding
1	0003729	molecular_function	mRNA binding
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005681	cellular_component	spliceosomal complex
1	0005684	cellular_component	U2-type spliceosomal complex
1	0005686	cellular_component	U2 snRNP
1	0005689	cellular_component	U12-type spliceosomal complex
1	0005730	cellular_component	nucleolus
1	0006338	biological_process	chromatin remodeling
1	0006397	biological_process	mRNA processing
1	0008380	biological_process	RNA splicing
1	0016607	cellular_component	nuclear speck
1	0034693	cellular_component	U11/U12 snRNP
1	0045943	biological_process	positive regulation of transcription by RNA polymerase I
1	0045944	biological_process	positive regulation of transcription by RNA polymerase II
1	0045945	biological_process	positive regulation of transcription by RNA polymerase III
1	0071004	cellular_component	U2-type prespliceosome
1	0071005	cellular_component	U2-type precatalytic spliceosome
1	0071013	cellular_component	catalytic step 2 spliceosome
1	0110016	cellular_component	B-WICH complex
1	1903241	biological_process	U2-type prespliceosome assembly
1	1990935	molecular_function	splicing factor binding
2	0000398	biological_process	mRNA splicing, via spliceosome
2	0003723	molecular_function	RNA binding
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005681	cellular_component	spliceosomal complex
2	0005684	cellular_component	U2-type spliceosomal complex
2	0005686	cellular_component	U2 snRNP
2	0005689	cellular_component	U12-type spliceosomal complex
2	0006397	biological_process	mRNA processing
2	0008380	biological_process	RNA splicing
2	0016607	cellular_component	nuclear speck
2	0071005	cellular_component	U2-type precatalytic spliceosome
2	0071011	cellular_component	precatalytic spliceosome
2	0071013	cellular_component	catalytic step 2 spliceosome
2	1903241	biological_process	U2-type prespliceosome assembly
3	0000124	cellular_component	SAGA complex
3	0000375	biological_process	RNA splicing, via transesterification reactions
3	0000398	biological_process	mRNA splicing, via spliceosome
3	0003676	molecular_function	nucleic acid binding
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005681	cellular_component	spliceosomal complex
3	0005684	cellular_component	U2-type spliceosomal complex
3	0005686	cellular_component	U2 snRNP
3	0005689	cellular_component	U12-type spliceosomal complex
3	0005730	cellular_component	nucleolus
3	0006282	biological_process	regulation of DNA repair
3	0006397	biological_process	mRNA processing
3	0008380	biological_process	RNA splicing
3	0030620	molecular_function	U2 snRNA binding
3	0042177	biological_process	negative regulation of protein catabolic process
3	0043484	biological_process	regulation of RNA splicing
3	0044877	molecular_function	protein-containing complex binding
3	0045893	biological_process	positive regulation of DNA-templated transcription
3	0071005	cellular_component	U2-type precatalytic spliceosome
3	0071013	cellular_component	catalytic step 2 spliceosome
3	1903241	biological_process	U2-type prespliceosome assembly
4	0000375	biological_process	RNA splicing, via transesterification reactions
4	0000398	biological_process	mRNA splicing, via spliceosome
4	0003676	molecular_function	nucleic acid binding
4	0003723	molecular_function	RNA binding
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005681	cellular_component	spliceosomal complex
4	0005684	cellular_component	U2-type spliceosomal complex
4	0005686	cellular_component	U2 snRNP
4	0005689	cellular_component	U12-type spliceosomal complex
4	0005730	cellular_component	nucleolus
4	0006397	biological_process	mRNA processing
4	0008380	biological_process	RNA splicing
4	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
4	0071005	cellular_component	U2-type precatalytic spliceosome
4	1903241	biological_process	U2-type prespliceosome assembly
4	1990935	molecular_function	splicing factor binding
5	0000398	biological_process	mRNA splicing, via spliceosome
5	0001825	biological_process	blastocyst formation
5	0003676	molecular_function	nucleic acid binding
5	0003723	molecular_function	RNA binding
5	0003729	molecular_function	mRNA binding
5	0005515	molecular_function	protein binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005681	cellular_component	spliceosomal complex
5	0005684	cellular_component	U2-type spliceosomal complex
5	0005686	cellular_component	U2 snRNP
5	0005689	cellular_component	U12-type spliceosomal complex
5	0006397	biological_process	mRNA processing
5	0008380	biological_process	RNA splicing
5	0071011	cellular_component	precatalytic spliceosome
5	0071013	cellular_component	catalytic step 2 spliceosome
5	1903241	biological_process	U2-type prespliceosome assembly
6	0000398	biological_process	mRNA splicing, via spliceosome
6	0003677	molecular_function	DNA binding
6	0003723	molecular_function	RNA binding
6	0005515	molecular_function	protein binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005681	cellular_component	spliceosomal complex
6	0005684	cellular_component	U2-type spliceosomal complex
6	0005686	cellular_component	U2 snRNP
6	0005689	cellular_component	U12-type spliceosomal complex
6	0006397	biological_process	mRNA processing
6	0008270	molecular_function	zinc ion binding
6	0008380	biological_process	RNA splicing
6	0016363	cellular_component	nuclear matrix
6	0016607	cellular_component	nuclear speck
6	0045893	biological_process	positive regulation of DNA-templated transcription
6	0046872	molecular_function	metal ion binding
6	0048863	biological_process	stem cell differentiation
6	0071005	cellular_component	U2-type precatalytic spliceosome
6	0071011	cellular_component	precatalytic spliceosome
6	0071013	cellular_component	catalytic step 2 spliceosome
6	1903241	biological_process	U2-type prespliceosome assembly
7	0000124	cellular_component	SAGA complex
7	0000398	biological_process	mRNA splicing, via spliceosome
7	0003723	molecular_function	RNA binding
7	0005515	molecular_function	protein binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005681	cellular_component	spliceosomal complex
7	0005684	cellular_component	U2-type spliceosomal complex
7	0005686	cellular_component	U2 snRNP
7	0005689	cellular_component	U12-type spliceosomal complex
7	0006282	biological_process	regulation of DNA repair
7	0006397	biological_process	mRNA processing
7	0008380	biological_process	RNA splicing
7	0043484	biological_process	regulation of RNA splicing
7	0045893	biological_process	positive regulation of DNA-templated transcription
7	0071005	cellular_component	U2-type precatalytic spliceosome
7	0071011	cellular_component	precatalytic spliceosome
7	1903241	biological_process	U2-type prespliceosome assembly
7	1990935	molecular_function	splicing factor binding
8	0000398	biological_process	mRNA splicing, via spliceosome
8	0003676	molecular_function	nucleic acid binding
8	0003677	molecular_function	DNA binding
8	0005515	molecular_function	protein binding
8	0005634	cellular_component	nucleus
8	0005654	cellular_component	nucleoplasm
8	0005681	cellular_component	spliceosomal complex
8	0006397	biological_process	mRNA processing
8	0008270	molecular_function	zinc ion binding
8	0008380	biological_process	RNA splicing
8	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
8	0046872	molecular_function	metal ion binding
8	0071005	cellular_component	U2-type precatalytic spliceosome
9	0000387	biological_process	spliceosomal snRNP assembly
9	0000398	biological_process	mRNA splicing, via spliceosome
9	0000481	biological_process	maturation of 5S rRNA
9	0003723	molecular_function	RNA binding
9	0005515	molecular_function	protein binding
9	0005634	cellular_component	nucleus
9	0005654	cellular_component	nucleoplasm
9	0005681	cellular_component	spliceosomal complex
9	0005737	cellular_component	cytoplasm
9	0005794	cellular_component	Golgi apparatus
9	0005829	cellular_component	cytosol
9	0006397	biological_process	mRNA processing
9	0008380	biological_process	RNA splicing
9	0015030	cellular_component	Cajal body
9	0016607	cellular_component	nuclear speck
9	0045292	biological_process	mRNA cis splicing, via spliceosome
9	0045585	biological_process	positive regulation of cytotoxic T cell differentiation
9	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
9	0071005	cellular_component	U2-type precatalytic spliceosome
9	0071013	cellular_component	catalytic step 2 spliceosome
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000375	biological_process	RNA splicing, via transesterification reactions
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0006397	biological_process	mRNA processing
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008380	biological_process	RNA splicing
A	0016020	cellular_component	membrane
A	0016607	cellular_component	nuclear speck
A	0017070	molecular_function	U6 snRNA binding
A	0030532	cellular_component	small nuclear ribonucleoprotein complex
A	0030619	molecular_function	U1 snRNA binding
A	0030620	molecular_function	U2 snRNA binding
A	0030623	molecular_function	U5 snRNA binding
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0070530	molecular_function	K63-linked polyubiquitin modification-dependent protein binding
A	0071005	cellular_component	U2-type precatalytic spliceosome
A	0071006	cellular_component	U2-type catalytic step 1 spliceosome
A	0071007	cellular_component	U2-type catalytic step 2 spliceosome
A	0071013	cellular_component	catalytic step 2 spliceosome
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0097157	molecular_function	pre-mRNA intronic binding
A	0140492	molecular_function	metal-dependent deubiquitinase activity
A	1990904	cellular_component	ribonucleoprotein complex
A0	0000398	biological_process	mRNA splicing, via spliceosome
A0	0005515	molecular_function	protein binding
A0	0005634	cellular_component	nucleus
A0	0005654	cellular_component	nucleoplasm
A0	0005737	cellular_component	cytoplasm
A0	0015030	cellular_component	Cajal body
A0	0031386	molecular_function	protein tag activity
A0	0036211	biological_process	protein modification process
A0	1903955	biological_process	positive regulation of protein targeting to mitochondrion
C	0000166	molecular_function	nucleotide binding
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0003723	molecular_function	RNA binding
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005681	cellular_component	spliceosomal complex
C	0005829	cellular_component	cytosol
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0015030	cellular_component	Cajal body
C	0016020	cellular_component	membrane
C	0016607	cellular_component	nuclear speck
C	0030623	molecular_function	U5 snRNA binding
C	0042220	biological_process	response to cocaine
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0071005	cellular_component	U2-type precatalytic spliceosome
C	0071007	cellular_component	U2-type catalytic step 2 spliceosome
C	0071013	cellular_component	catalytic step 2 spliceosome
C	0071466	biological_process	cellular response to xenobiotic stimulus
D	0000166	molecular_function	nucleotide binding
D	0000354	biological_process	cis assembly of pre-catalytic spliceosome
D	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0001649	biological_process	osteoblast differentiation
D	0003676	molecular_function	nucleic acid binding
D	0003723	molecular_function	RNA binding
D	0003724	molecular_function	RNA helicase activity
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005681	cellular_component	spliceosomal complex
D	0005682	cellular_component	U5 snRNP
D	0006397	biological_process	mRNA processing
D	0008380	biological_process	RNA splicing
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0042802	molecular_function	identical protein binding
D	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
D	0071005	cellular_component	U2-type precatalytic spliceosome
D	0071006	cellular_component	U2-type catalytic step 1 spliceosome
D	0071013	cellular_component	catalytic step 2 spliceosome
D	0071840	biological_process	cellular component organization or biogenesis
E	0000375	biological_process	RNA splicing, via transesterification reactions
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005681	cellular_component	spliceosomal complex
E	0005682	cellular_component	U5 snRNP
E	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
E	0005829	cellular_component	cytosol
E	0006396	biological_process	RNA processing
E	0006397	biological_process	mRNA processing
E	0008380	biological_process	RNA splicing
E	0016607	cellular_component	nuclear speck
E	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
E	0071007	cellular_component	U2-type catalytic step 2 spliceosome
E	0071013	cellular_component	catalytic step 2 spliceosome
J	0000244	biological_process	spliceosomal tri-snRNP complex assembly
J	0000375	biological_process	RNA splicing, via transesterification reactions
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005681	cellular_component	spliceosomal complex
J	0005829	cellular_component	cytosol
J	0006397	biological_process	mRNA processing
J	0008380	biological_process	RNA splicing
J	0015030	cellular_component	Cajal body
J	0016607	cellular_component	nuclear speck
J	0032991	cellular_component	protein-containing complex
J	0042802	molecular_function	identical protein binding
J	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
J	0071005	cellular_component	U2-type precatalytic spliceosome
K	0000375	biological_process	RNA splicing, via transesterification reactions
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005681	cellular_component	spliceosomal complex
K	0006396	biological_process	RNA processing
K	0006397	biological_process	mRNA processing
K	0008380	biological_process	RNA splicing
K	0015030	cellular_component	Cajal body
K	0016607	cellular_component	nuclear speck
K	0017070	molecular_function	U6 snRNA binding
K	0030621	molecular_function	U4 snRNA binding
K	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
K	0071001	cellular_component	U4/U6 snRNP
K	0071005	cellular_component	U2-type precatalytic spliceosome
K	0097525	cellular_component	spliceosomal snRNP complex
L	0000244	biological_process	spliceosomal tri-snRNP complex assembly
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0003723	molecular_function	RNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005681	cellular_component	spliceosomal complex
L	0005684	cellular_component	U2-type spliceosomal complex
L	0005687	cellular_component	U4 snRNP
L	0005690	cellular_component	U4atac snRNP
L	0006397	biological_process	mRNA processing
L	0008380	biological_process	RNA splicing
L	0015030	cellular_component	Cajal body
L	0016607	cellular_component	nuclear speck
L	0030621	molecular_function	U4 snRNA binding
L	0030622	molecular_function	U4atac snRNA binding
L	0030674	molecular_function	protein-macromolecule adaptor activity
L	0042802	molecular_function	identical protein binding
L	0043021	molecular_function	ribonucleoprotein complex binding
L	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
L	0048254	biological_process	snoRNA localization
L	0070990	molecular_function	snRNP binding
L	0071005	cellular_component	U2-type precatalytic spliceosome
L	0071011	cellular_component	precatalytic spliceosome
L	0071166	biological_process	ribonucleoprotein complex localization
L	0071339	cellular_component	MLL1 complex
L	0097526	cellular_component	spliceosomal tri-snRNP complex
L	1990904	cellular_component	ribonucleoprotein complex
M	0000398	biological_process	mRNA splicing, via spliceosome
M	0000470	biological_process	maturation of LSU-rRNA
M	0000492	biological_process	box C/D snoRNP assembly
M	0001651	cellular_component	dense fibrillar component
M	0003723	molecular_function	RNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005681	cellular_component	spliceosomal complex
M	0005690	cellular_component	U4atac snRNP
M	0005730	cellular_component	nucleolus
M	0006397	biological_process	mRNA processing
M	0007338	biological_process	single fertilization
M	0008380	biological_process	RNA splicing
M	0022625	cellular_component	cytosolic large ribosomal subunit
M	0030490	biological_process	maturation of SSU-rRNA
M	0030515	molecular_function	snoRNA binding
M	0030621	molecular_function	U4 snRNA binding
M	0030622	molecular_function	U4atac snRNA binding
M	0031428	cellular_component	box C/D methylation guide snoRNP complex
M	0032040	cellular_component	small-subunit processome
M	0032991	cellular_component	protein-containing complex
M	0034511	molecular_function	U3 snoRNA binding
M	0034512	molecular_function	box C/D sno(s)RNA binding
M	0042254	biological_process	ribosome biogenesis
M	0042274	biological_process	ribosomal small subunit biogenesis
M	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
M	0051117	molecular_function	ATPase binding
M	0071005	cellular_component	U2-type precatalytic spliceosome
M	0071011	cellular_component	precatalytic spliceosome
M	1990904	cellular_component	ribonucleoprotein complex
N	0000244	biological_process	spliceosomal tri-snRNP complex assembly
N	0000245	biological_process	spliceosomal complex assembly
N	0000375	biological_process	RNA splicing, via transesterification reactions
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0003723	molecular_function	RNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005681	cellular_component	spliceosomal complex
N	0005682	cellular_component	U5 snRNP
N	0006396	biological_process	RNA processing
N	0006397	biological_process	mRNA processing
N	0006403	biological_process	RNA localization
N	0008380	biological_process	RNA splicing
N	0016020	cellular_component	membrane
N	0016607	cellular_component	nuclear speck
N	0030674	molecular_function	protein-macromolecule adaptor activity
N	0042802	molecular_function	identical protein binding
N	0043021	molecular_function	ribonucleoprotein complex binding
N	0045944	biological_process	positive regulation of transcription by RNA polymerase II
N	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
N	0071005	cellular_component	U2-type precatalytic spliceosome
N	0071013	cellular_component	catalytic step 2 spliceosome
N	2000630	biological_process	positive regulation of miRNA metabolic process
N	2000636	biological_process	positive regulation of primary miRNA processing
O	0000245	biological_process	spliceosomal complex assembly
O	0000375	biological_process	RNA splicing, via transesterification reactions
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005681	cellular_component	spliceosomal complex
O	0005682	cellular_component	U5 snRNP
O	0005829	cellular_component	cytosol
O	0006397	biological_process	mRNA processing
O	0007049	biological_process	cell cycle
O	0008380	biological_process	RNA splicing
O	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
O	0051301	biological_process	cell division
O	0071005	cellular_component	U2-type precatalytic spliceosome
P	0000245	biological_process	spliceosomal complex assembly
P	0000387	biological_process	spliceosomal snRNP assembly
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005681	cellular_component	spliceosomal complex
P	0005682	cellular_component	U5 snRNP
P	0005684	cellular_component	U2-type spliceosomal complex
P	0005685	cellular_component	U1 snRNP
P	0005686	cellular_component	U2 snRNP
P	0005687	cellular_component	U4 snRNP
P	0005689	cellular_component	U12-type spliceosomal complex
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006397	biological_process	mRNA processing
P	0008380	biological_process	RNA splicing
P	0030532	cellular_component	small nuclear ribonucleoprotein complex
P	0034709	cellular_component	methylosome
P	0034715	cellular_component	pICln-Sm protein complex
P	0034719	cellular_component	SMN-Sm protein complex
P	0036261	biological_process	7-methylguanosine cap hypermethylation
P	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
P	0070062	cellular_component	extracellular exosome
P	0071005	cellular_component	U2-type precatalytic spliceosome
P	0071007	cellular_component	U2-type catalytic step 2 spliceosome
P	0071011	cellular_component	precatalytic spliceosome
P	0071013	cellular_component	catalytic step 2 spliceosome
P	1903241	biological_process	U2-type prespliceosome assembly
P	1990904	cellular_component	ribonucleoprotein complex
Q	0000387	biological_process	spliceosomal snRNP assembly
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0003723	molecular_function	RNA binding
Q	0005681	cellular_component	spliceosomal complex
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0003723	molecular_function	RNA binding
R	0005681	cellular_component	spliceosomal complex
S	0000245	biological_process	spliceosomal complex assembly
S	0000387	biological_process	spliceosomal snRNP assembly
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005681	cellular_component	spliceosomal complex
S	0005682	cellular_component	U5 snRNP
S	0005683	cellular_component	U7 snRNP
S	0005684	cellular_component	U2-type spliceosomal complex
S	0005685	cellular_component	U1 snRNP
S	0005686	cellular_component	U2 snRNP
S	0005687	cellular_component	U4 snRNP
S	0005689	cellular_component	U12-type spliceosomal complex
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0006397	biological_process	mRNA processing
S	0008380	biological_process	RNA splicing
S	0030532	cellular_component	small nuclear ribonucleoprotein complex
S	0034709	cellular_component	methylosome
S	0034719	cellular_component	SMN-Sm protein complex
S	0036261	biological_process	7-methylguanosine cap hypermethylation
S	0043186	cellular_component	P granule
S	0043229	cellular_component	intracellular organelle
S	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
S	0071004	cellular_component	U2-type prespliceosome
S	0071005	cellular_component	U2-type precatalytic spliceosome
S	0071007	cellular_component	U2-type catalytic step 2 spliceosome
S	0071011	cellular_component	precatalytic spliceosome
S	0071013	cellular_component	catalytic step 2 spliceosome
S	0097526	cellular_component	spliceosomal tri-snRNP complex
S	1903241	biological_process	U2-type prespliceosome assembly
S	1990904	cellular_component	ribonucleoprotein complex
T	0000243	cellular_component	commitment complex
T	0000387	biological_process	spliceosomal snRNP assembly
T	0000398	biological_process	mRNA splicing, via spliceosome
T	0003723	molecular_function	RNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005681	cellular_component	spliceosomal complex
T	0005682	cellular_component	U5 snRNP
T	0005683	cellular_component	U7 snRNP
T	0005684	cellular_component	U2-type spliceosomal complex
T	0005685	cellular_component	U1 snRNP
T	0005686	cellular_component	U2 snRNP
T	0005687	cellular_component	U4 snRNP
T	0005689	cellular_component	U12-type spliceosomal complex
T	0005697	cellular_component	telomerase holoenzyme complex
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0006396	biological_process	RNA processing
T	0006397	biological_process	mRNA processing
T	0006479	biological_process	protein methylation
T	0008380	biological_process	RNA splicing
T	0016604	cellular_component	nuclear body
T	0019899	molecular_function	enzyme binding
T	0030532	cellular_component	small nuclear ribonucleoprotein complex
T	0034709	cellular_component	methylosome
T	0034715	cellular_component	pICln-Sm protein complex
T	0034719	cellular_component	SMN-Sm protein complex
T	0036261	biological_process	7-methylguanosine cap hypermethylation
T	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
T	0070034	molecular_function	telomerase RNA binding
T	0071005	cellular_component	U2-type precatalytic spliceosome
T	0071007	cellular_component	U2-type catalytic step 2 spliceosome
T	0071011	cellular_component	precatalytic spliceosome
T	0071013	cellular_component	catalytic step 2 spliceosome
T	0071208	molecular_function	histone pre-mRNA DCP binding
T	0071209	molecular_function	U7 snRNA binding
T	0097526	cellular_component	spliceosomal tri-snRNP complex
T	1903241	biological_process	U2-type prespliceosome assembly
T	1990446	molecular_function	U1 snRNP binding
T	1990904	cellular_component	ribonucleoprotein complex
U	0003723	molecular_function	RNA binding
V	0000243	cellular_component	commitment complex
V	0000245	biological_process	spliceosomal complex assembly
V	0000387	biological_process	spliceosomal snRNP assembly
V	0000398	biological_process	mRNA splicing, via spliceosome
V	0003723	molecular_function	RNA binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005681	cellular_component	spliceosomal complex
V	0005682	cellular_component	U5 snRNP
V	0005684	cellular_component	U2-type spliceosomal complex
V	0005685	cellular_component	U1 snRNP
V	0005686	cellular_component	U2 snRNP
V	0005687	cellular_component	U4 snRNP
V	0005689	cellular_component	U12-type spliceosomal complex
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0006396	biological_process	RNA processing
V	0006397	biological_process	mRNA processing
V	0008380	biological_process	RNA splicing
V	0030532	cellular_component	small nuclear ribonucleoprotein complex
V	0034709	cellular_component	methylosome
V	0034715	cellular_component	pICln-Sm protein complex
V	0034719	cellular_component	SMN-Sm protein complex
V	0036261	biological_process	7-methylguanosine cap hypermethylation
V	0043229	cellular_component	intracellular organelle
V	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
V	0071005	cellular_component	U2-type precatalytic spliceosome
V	0071007	cellular_component	U2-type catalytic step 2 spliceosome
V	0071011	cellular_component	precatalytic spliceosome
V	0071013	cellular_component	catalytic step 2 spliceosome
V	0097526	cellular_component	spliceosomal tri-snRNP complex
V	1903241	biological_process	U2-type prespliceosome assembly
V	1990904	cellular_component	ribonucleoprotein complex
W	0000398	biological_process	mRNA splicing, via spliceosome
W	0000413	biological_process	protein peptidyl-prolyl isomerization
W	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005681	cellular_component	spliceosomal complex
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005886	cellular_component	plasma membrane
W	0006397	biological_process	mRNA processing
W	0006457	biological_process	protein folding
W	0008380	biological_process	RNA splicing
W	0016018	molecular_function	cyclosporin A binding
W	0016607	cellular_component	nuclear speck
W	0016853	molecular_function	isomerase activity
W	0043021	molecular_function	ribonucleoprotein complex binding
W	0043231	cellular_component	intracellular membrane-bounded organelle
W	0045070	biological_process	positive regulation of viral genome replication
W	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
W	0065003	biological_process	protein-containing complex assembly
W	0071001	cellular_component	U4/U6 snRNP
X	0000398	biological_process	mRNA splicing, via spliceosome
X	0003676	molecular_function	nucleic acid binding
X	0003723	molecular_function	RNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005681	cellular_component	spliceosomal complex
X	0006397	biological_process	mRNA processing
X	0008270	molecular_function	zinc ion binding
X	0008380	biological_process	RNA splicing
X	0016607	cellular_component	nuclear speck
X	0045292	biological_process	mRNA cis splicing, via spliceosome
X	0046872	molecular_function	metal ion binding
X	0070064	molecular_function	proline-rich region binding
X	0071005	cellular_component	U2-type precatalytic spliceosome
X	0071011	cellular_component	precatalytic spliceosome
Y	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
Y	0000398	biological_process	mRNA splicing, via spliceosome
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005737	cellular_component	cytoplasm
Y	0006397	biological_process	mRNA processing
Y	0008380	biological_process	RNA splicing
Y	0016607	cellular_component	nuclear speck
Y	0071005	cellular_component	U2-type precatalytic spliceosome
Y	0071011	cellular_component	precatalytic spliceosome
Z	0000398	biological_process	mRNA splicing, via spliceosome
Z	0003723	molecular_function	RNA binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005681	cellular_component	spliceosomal complex
Z	0006397	biological_process	mRNA processing
Z	0008380	biological_process	RNA splicing
Z	0071005	cellular_component	U2-type precatalytic spliceosome
Z	0071011	cellular_component	precatalytic spliceosome
a	0003723	molecular_function	RNA binding
b	0000243	cellular_component	commitment complex
b	0000245	biological_process	spliceosomal complex assembly
b	0000387	biological_process	spliceosomal snRNP assembly
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005681	cellular_component	spliceosomal complex
b	0005682	cellular_component	U5 snRNP
b	0005684	cellular_component	U2-type spliceosomal complex
b	0005685	cellular_component	U1 snRNP
b	0005686	cellular_component	U2 snRNP
b	0005687	cellular_component	U4 snRNP
b	0005689	cellular_component	U12-type spliceosomal complex
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0006396	biological_process	RNA processing
b	0006397	biological_process	mRNA processing
b	0008380	biological_process	RNA splicing
b	0030532	cellular_component	small nuclear ribonucleoprotein complex
b	0034709	cellular_component	methylosome
b	0034715	cellular_component	pICln-Sm protein complex
b	0034719	cellular_component	SMN-Sm protein complex
b	0036261	biological_process	7-methylguanosine cap hypermethylation
b	0043229	cellular_component	intracellular organelle
b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
b	0071005	cellular_component	U2-type precatalytic spliceosome
b	0071007	cellular_component	U2-type catalytic step 2 spliceosome
b	0071011	cellular_component	precatalytic spliceosome
b	0071013	cellular_component	catalytic step 2 spliceosome
b	0097526	cellular_component	spliceosomal tri-snRNP complex
b	1903241	biological_process	U2-type prespliceosome assembly
b	1990904	cellular_component	ribonucleoprotein complex
c	0000245	biological_process	spliceosomal complex assembly
c	0000387	biological_process	spliceosomal snRNP assembly
c	0000398	biological_process	mRNA splicing, via spliceosome
c	0003723	molecular_function	RNA binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005681	cellular_component	spliceosomal complex
c	0005682	cellular_component	U5 snRNP
c	0005684	cellular_component	U2-type spliceosomal complex
c	0005685	cellular_component	U1 snRNP
c	0005686	cellular_component	U2 snRNP
c	0005687	cellular_component	U4 snRNP
c	0005689	cellular_component	U12-type spliceosomal complex
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0006397	biological_process	mRNA processing
c	0008380	biological_process	RNA splicing
c	0030532	cellular_component	small nuclear ribonucleoprotein complex
c	0034709	cellular_component	methylosome
c	0034715	cellular_component	pICln-Sm protein complex
c	0034719	cellular_component	SMN-Sm protein complex
c	0036261	biological_process	7-methylguanosine cap hypermethylation
c	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
c	0070062	cellular_component	extracellular exosome
c	0071005	cellular_component	U2-type precatalytic spliceosome
c	0071007	cellular_component	U2-type catalytic step 2 spliceosome
c	0071011	cellular_component	precatalytic spliceosome
c	0071013	cellular_component	catalytic step 2 spliceosome
c	1903241	biological_process	U2-type prespliceosome assembly
c	1990904	cellular_component	ribonucleoprotein complex
d	0000387	biological_process	spliceosomal snRNP assembly
d	0000398	biological_process	mRNA splicing, via spliceosome
d	0003723	molecular_function	RNA binding
d	0005681	cellular_component	spliceosomal complex
e	0000398	biological_process	mRNA splicing, via spliceosome
e	0003723	molecular_function	RNA binding
e	0005681	cellular_component	spliceosomal complex
f	0000245	biological_process	spliceosomal complex assembly
f	0000387	biological_process	spliceosomal snRNP assembly
f	0000398	biological_process	mRNA splicing, via spliceosome
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005681	cellular_component	spliceosomal complex
f	0005682	cellular_component	U5 snRNP
f	0005683	cellular_component	U7 snRNP
f	0005684	cellular_component	U2-type spliceosomal complex
f	0005685	cellular_component	U1 snRNP
f	0005686	cellular_component	U2 snRNP
f	0005687	cellular_component	U4 snRNP
f	0005689	cellular_component	U12-type spliceosomal complex
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0006397	biological_process	mRNA processing
f	0008380	biological_process	RNA splicing
f	0030532	cellular_component	small nuclear ribonucleoprotein complex
f	0034709	cellular_component	methylosome
f	0034719	cellular_component	SMN-Sm protein complex
f	0036261	biological_process	7-methylguanosine cap hypermethylation
f	0043186	cellular_component	P granule
f	0043229	cellular_component	intracellular organelle
f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
f	0071004	cellular_component	U2-type prespliceosome
f	0071005	cellular_component	U2-type precatalytic spliceosome
f	0071007	cellular_component	U2-type catalytic step 2 spliceosome
f	0071011	cellular_component	precatalytic spliceosome
f	0071013	cellular_component	catalytic step 2 spliceosome
f	0097526	cellular_component	spliceosomal tri-snRNP complex
f	1903241	biological_process	U2-type prespliceosome assembly
f	1990904	cellular_component	ribonucleoprotein complex
g	0000243	cellular_component	commitment complex
g	0000387	biological_process	spliceosomal snRNP assembly
g	0000398	biological_process	mRNA splicing, via spliceosome
g	0003723	molecular_function	RNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005681	cellular_component	spliceosomal complex
g	0005682	cellular_component	U5 snRNP
g	0005683	cellular_component	U7 snRNP
g	0005684	cellular_component	U2-type spliceosomal complex
g	0005685	cellular_component	U1 snRNP
g	0005686	cellular_component	U2 snRNP
g	0005687	cellular_component	U4 snRNP
g	0005689	cellular_component	U12-type spliceosomal complex
g	0005697	cellular_component	telomerase holoenzyme complex
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0006396	biological_process	RNA processing
g	0006397	biological_process	mRNA processing
g	0006479	biological_process	protein methylation
g	0008380	biological_process	RNA splicing
g	0016604	cellular_component	nuclear body
g	0019899	molecular_function	enzyme binding
g	0030532	cellular_component	small nuclear ribonucleoprotein complex
g	0034709	cellular_component	methylosome
g	0034715	cellular_component	pICln-Sm protein complex
g	0034719	cellular_component	SMN-Sm protein complex
g	0036261	biological_process	7-methylguanosine cap hypermethylation
g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
g	0070034	molecular_function	telomerase RNA binding
g	0071005	cellular_component	U2-type precatalytic spliceosome
g	0071007	cellular_component	U2-type catalytic step 2 spliceosome
g	0071011	cellular_component	precatalytic spliceosome
g	0071013	cellular_component	catalytic step 2 spliceosome
g	0071208	molecular_function	histone pre-mRNA DCP binding
g	0071209	molecular_function	U7 snRNA binding
g	0097526	cellular_component	spliceosomal tri-snRNP complex
g	1903241	biological_process	U2-type prespliceosome assembly
g	1990446	molecular_function	U1 snRNP binding
g	1990904	cellular_component	ribonucleoprotein complex
h	0000243	cellular_component	commitment complex
h	0000387	biological_process	spliceosomal snRNP assembly
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0003723	molecular_function	RNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005681	cellular_component	spliceosomal complex
h	0005682	cellular_component	U5 snRNP
h	0005683	cellular_component	U7 snRNP
h	0005684	cellular_component	U2-type spliceosomal complex
h	0005685	cellular_component	U1 snRNP
h	0005686	cellular_component	U2 snRNP
h	0005687	cellular_component	U4 snRNP
h	0005689	cellular_component	U12-type spliceosomal complex
h	0005697	cellular_component	telomerase holoenzyme complex
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0006396	biological_process	RNA processing
h	0006397	biological_process	mRNA processing
h	0006479	biological_process	protein methylation
h	0008380	biological_process	RNA splicing
h	0016604	cellular_component	nuclear body
h	0019899	molecular_function	enzyme binding
h	0030532	cellular_component	small nuclear ribonucleoprotein complex
h	0034709	cellular_component	methylosome
h	0034715	cellular_component	pICln-Sm protein complex
h	0034719	cellular_component	SMN-Sm protein complex
h	0036261	biological_process	7-methylguanosine cap hypermethylation
h	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
h	0070034	molecular_function	telomerase RNA binding
h	0071005	cellular_component	U2-type precatalytic spliceosome
h	0071007	cellular_component	U2-type catalytic step 2 spliceosome
h	0071011	cellular_component	precatalytic spliceosome
h	0071013	cellular_component	catalytic step 2 spliceosome
h	0071208	molecular_function	histone pre-mRNA DCP binding
h	0071209	molecular_function	U7 snRNA binding
h	0097526	cellular_component	spliceosomal tri-snRNP complex
h	1903241	biological_process	U2-type prespliceosome assembly
h	1990446	molecular_function	U1 snRNP binding
h	1990904	cellular_component	ribonucleoprotein complex
i	0003723	molecular_function	RNA binding
j	0000243	cellular_component	commitment complex
j	0000245	biological_process	spliceosomal complex assembly
j	0000387	biological_process	spliceosomal snRNP assembly
j	0000398	biological_process	mRNA splicing, via spliceosome
j	0003723	molecular_function	RNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005681	cellular_component	spliceosomal complex
j	0005682	cellular_component	U5 snRNP
j	0005684	cellular_component	U2-type spliceosomal complex
j	0005685	cellular_component	U1 snRNP
j	0005686	cellular_component	U2 snRNP
j	0005687	cellular_component	U4 snRNP
j	0005689	cellular_component	U12-type spliceosomal complex
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0006396	biological_process	RNA processing
j	0006397	biological_process	mRNA processing
j	0008380	biological_process	RNA splicing
j	0030532	cellular_component	small nuclear ribonucleoprotein complex
j	0034709	cellular_component	methylosome
j	0034715	cellular_component	pICln-Sm protein complex
j	0034719	cellular_component	SMN-Sm protein complex
j	0036261	biological_process	7-methylguanosine cap hypermethylation
j	0043229	cellular_component	intracellular organelle
j	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
j	0071005	cellular_component	U2-type precatalytic spliceosome
j	0071007	cellular_component	U2-type catalytic step 2 spliceosome
j	0071011	cellular_component	precatalytic spliceosome
j	0071013	cellular_component	catalytic step 2 spliceosome
j	0097526	cellular_component	spliceosomal tri-snRNP complex
j	1903241	biological_process	U2-type prespliceosome assembly
j	1990904	cellular_component	ribonucleoprotein complex
k	0000245	biological_process	spliceosomal complex assembly
k	0000387	biological_process	spliceosomal snRNP assembly
k	0000398	biological_process	mRNA splicing, via spliceosome
k	0003723	molecular_function	RNA binding
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005681	cellular_component	spliceosomal complex
k	0005682	cellular_component	U5 snRNP
k	0005684	cellular_component	U2-type spliceosomal complex
k	0005685	cellular_component	U1 snRNP
k	0005686	cellular_component	U2 snRNP
k	0005687	cellular_component	U4 snRNP
k	0005689	cellular_component	U12-type spliceosomal complex
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0006397	biological_process	mRNA processing
k	0008380	biological_process	RNA splicing
k	0030532	cellular_component	small nuclear ribonucleoprotein complex
k	0034709	cellular_component	methylosome
k	0034715	cellular_component	pICln-Sm protein complex
k	0034719	cellular_component	SMN-Sm protein complex
k	0036261	biological_process	7-methylguanosine cap hypermethylation
k	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
k	0070062	cellular_component	extracellular exosome
k	0071005	cellular_component	U2-type precatalytic spliceosome
k	0071007	cellular_component	U2-type catalytic step 2 spliceosome
k	0071011	cellular_component	precatalytic spliceosome
k	0071013	cellular_component	catalytic step 2 spliceosome
k	1903241	biological_process	U2-type prespliceosome assembly
k	1990904	cellular_component	ribonucleoprotein complex
l	0000387	biological_process	spliceosomal snRNP assembly
l	0000398	biological_process	mRNA splicing, via spliceosome
l	0003723	molecular_function	RNA binding
l	0005681	cellular_component	spliceosomal complex
m	0000398	biological_process	mRNA splicing, via spliceosome
m	0003723	molecular_function	RNA binding
m	0005681	cellular_component	spliceosomal complex
n	0000245	biological_process	spliceosomal complex assembly
n	0000387	biological_process	spliceosomal snRNP assembly
n	0000398	biological_process	mRNA splicing, via spliceosome
n	0003723	molecular_function	RNA binding
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005681	cellular_component	spliceosomal complex
n	0005682	cellular_component	U5 snRNP
n	0005683	cellular_component	U7 snRNP
n	0005684	cellular_component	U2-type spliceosomal complex
n	0005685	cellular_component	U1 snRNP
n	0005686	cellular_component	U2 snRNP
n	0005687	cellular_component	U4 snRNP
n	0005689	cellular_component	U12-type spliceosomal complex
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0006397	biological_process	mRNA processing
n	0008380	biological_process	RNA splicing
n	0030532	cellular_component	small nuclear ribonucleoprotein complex
n	0034709	cellular_component	methylosome
n	0034719	cellular_component	SMN-Sm protein complex
n	0036261	biological_process	7-methylguanosine cap hypermethylation
n	0043186	cellular_component	P granule
n	0043229	cellular_component	intracellular organelle
n	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
n	0071004	cellular_component	U2-type prespliceosome
n	0071005	cellular_component	U2-type precatalytic spliceosome
n	0071007	cellular_component	U2-type catalytic step 2 spliceosome
n	0071011	cellular_component	precatalytic spliceosome
n	0071013	cellular_component	catalytic step 2 spliceosome
n	0097526	cellular_component	spliceosomal tri-snRNP complex
n	1903241	biological_process	U2-type prespliceosome assembly
n	1990904	cellular_component	ribonucleoprotein complex
o	0000398	biological_process	mRNA splicing, via spliceosome
o	0003723	molecular_function	RNA binding
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005681	cellular_component	spliceosomal complex
o	0005684	cellular_component	U2-type spliceosomal complex
o	0005686	cellular_component	U2 snRNP
o	0006397	biological_process	mRNA processing
o	0007283	biological_process	spermatogenesis
o	0008380	biological_process	RNA splicing
o	0016604	cellular_component	nuclear body
o	0016607	cellular_component	nuclear speck
o	0030532	cellular_component	small nuclear ribonucleoprotein complex
o	0030620	molecular_function	U2 snRNA binding
o	0071005	cellular_component	U2-type precatalytic spliceosome
o	0071007	cellular_component	U2-type catalytic step 2 spliceosome
o	0071013	cellular_component	catalytic step 2 spliceosome
o	1903241	biological_process	U2-type prespliceosome assembly
o	1990904	cellular_component	ribonucleoprotein complex
p	0000398	biological_process	mRNA splicing, via spliceosome
p	0001650	cellular_component	fibrillar center
p	0003676	molecular_function	nucleic acid binding
p	0003723	molecular_function	RNA binding
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0005681	cellular_component	spliceosomal complex
p	0005684	cellular_component	U2-type spliceosomal complex
p	0005685	cellular_component	U1 snRNP
p	0005686	cellular_component	U2 snRNP
p	0006397	biological_process	mRNA processing
p	0008380	biological_process	RNA splicing
p	0016607	cellular_component	nuclear speck
p	0030619	molecular_function	U1 snRNA binding
p	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
p	0071005	cellular_component	U2-type precatalytic spliceosome
p	0071007	cellular_component	U2-type catalytic step 2 spliceosome
p	0071013	cellular_component	catalytic step 2 spliceosome
p	1903241	biological_process	U2-type prespliceosome assembly
p	1990904	cellular_component	ribonucleoprotein complex
q	0000244	biological_process	spliceosomal tri-snRNP complex assembly
q	0000398	biological_process	mRNA splicing, via spliceosome
q	0000932	cellular_component	P-body
q	0003723	molecular_function	RNA binding
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005681	cellular_component	spliceosomal complex
q	0005688	cellular_component	U6 snRNP
q	0005737	cellular_component	cytoplasm
q	0005829	cellular_component	cytosol
q	0006397	biological_process	mRNA processing
q	0006402	biological_process	mRNA catabolic process
q	0008380	biological_process	RNA splicing
q	0017070	molecular_function	U6 snRNA binding
q	0031267	molecular_function	small GTPase binding
q	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
q	0071005	cellular_component	U2-type precatalytic spliceosome
q	0071011	cellular_component	precatalytic spliceosome
q	0071013	cellular_component	catalytic step 2 spliceosome
q	0120115	cellular_component	Lsm2-8 complex
q	1990726	cellular_component	Lsm1-7-Pat1 complex
q	1990904	cellular_component	ribonucleoprotein complex
r	0000398	biological_process	mRNA splicing, via spliceosome
r	0000932	cellular_component	P-body
r	0003723	molecular_function	RNA binding
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0005681	cellular_component	spliceosomal complex
r	0005688	cellular_component	U6 snRNP
r	0005829	cellular_component	cytosol
r	0006397	biological_process	mRNA processing
r	0008380	biological_process	RNA splicing
r	0030629	molecular_function	U6 snRNA 3'-end binding
r	0032991	cellular_component	protein-containing complex
r	0033962	biological_process	P-body assembly
r	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
r	0071005	cellular_component	U2-type precatalytic spliceosome
r	0071011	cellular_component	precatalytic spliceosome
r	0071013	cellular_component	catalytic step 2 spliceosome
r	0120115	cellular_component	Lsm2-8 complex
r	1990726	cellular_component	Lsm1-7-Pat1 complex
r	1990904	cellular_component	ribonucleoprotein complex
s	0000387	biological_process	spliceosomal snRNP assembly
s	0000398	biological_process	mRNA splicing, via spliceosome
s	0000932	cellular_component	P-body
s	0000956	biological_process	nuclear-transcribed mRNA catabolic process
s	0003723	molecular_function	RNA binding
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0005681	cellular_component	spliceosomal complex
s	0005688	cellular_component	U6 snRNP
s	0005829	cellular_component	cytosol
s	0006396	biological_process	RNA processing
s	0006397	biological_process	mRNA processing
s	0008380	biological_process	RNA splicing
s	0016020	cellular_component	membrane
s	0017070	molecular_function	U6 snRNA binding
s	0032991	cellular_component	protein-containing complex
s	0033962	biological_process	P-body assembly
s	0042731	molecular_function	PH domain binding
s	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
s	0071005	cellular_component	U2-type precatalytic spliceosome
s	0097526	cellular_component	spliceosomal tri-snRNP complex
s	0120115	cellular_component	Lsm2-8 complex
s	1990904	cellular_component	ribonucleoprotein complex
t	0000398	biological_process	mRNA splicing, via spliceosome
t	0003723	molecular_function	RNA binding
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005681	cellular_component	spliceosomal complex
t	0005688	cellular_component	U6 snRNP
t	0005737	cellular_component	cytoplasm
t	0005829	cellular_component	cytosol
t	0006397	biological_process	mRNA processing
t	0006402	biological_process	mRNA catabolic process
t	0008380	biological_process	RNA splicing
t	0009617	biological_process	response to bacterium
t	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
t	0046982	molecular_function	protein heterodimerization activity
t	0071005	cellular_component	U2-type precatalytic spliceosome
t	0120115	cellular_component	Lsm2-8 complex
t	1990726	cellular_component	Lsm1-7-Pat1 complex
t	1990904	cellular_component	ribonucleoprotein complex
u	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
u	0000389	biological_process	mRNA 3'-splice site recognition
u	0000398	biological_process	mRNA splicing, via spliceosome
u	0003723	molecular_function	RNA binding
u	0005515	molecular_function	protein binding
u	0005634	cellular_component	nucleus
u	0005654	cellular_component	nucleoplasm
u	0005681	cellular_component	spliceosomal complex
u	0005684	cellular_component	U2-type spliceosomal complex
u	0005686	cellular_component	U2 snRNP
u	0006396	biological_process	RNA processing
u	0006397	biological_process	mRNA processing
u	0008380	biological_process	RNA splicing
u	0016607	cellular_component	nuclear speck
u	0045292	biological_process	mRNA cis splicing, via spliceosome
u	0071004	cellular_component	U2-type prespliceosome
u	0071005	cellular_component	U2-type precatalytic spliceosome
u	0071013	cellular_component	catalytic step 2 spliceosome
u	1903241	biological_process	U2-type prespliceosome assembly
v	0000245	biological_process	spliceosomal complex assembly
v	0000389	biological_process	mRNA 3'-splice site recognition
v	0000398	biological_process	mRNA splicing, via spliceosome
v	0003676	molecular_function	nucleic acid binding
v	0003723	molecular_function	RNA binding
v	0005515	molecular_function	protein binding
v	0005634	cellular_component	nucleus
v	0005654	cellular_component	nucleoplasm
v	0005681	cellular_component	spliceosomal complex
v	0005684	cellular_component	U2-type spliceosomal complex
v	0005686	cellular_component	U2 snRNP
v	0006397	biological_process	mRNA processing
v	0008270	molecular_function	zinc ion binding
v	0008380	biological_process	RNA splicing
v	0010976	biological_process	positive regulation of neuron projection development
v	0016607	cellular_component	nuclear speck
v	0046872	molecular_function	metal ion binding
v	0071004	cellular_component	U2-type prespliceosome
v	0071005	cellular_component	U2-type precatalytic spliceosome
v	0071013	cellular_component	catalytic step 2 spliceosome
v	1903241	biological_process	U2-type prespliceosome assembly
w	0000375	biological_process	RNA splicing, via transesterification reactions
w	0000389	biological_process	mRNA 3'-splice site recognition
w	0000398	biological_process	mRNA splicing, via spliceosome
w	0003676	molecular_function	nucleic acid binding
w	0003723	molecular_function	RNA binding
w	0005515	molecular_function	protein binding
w	0005634	cellular_component	nucleus
w	0005654	cellular_component	nucleoplasm
w	0005681	cellular_component	spliceosomal complex
w	0005684	cellular_component	U2-type spliceosomal complex
w	0005686	cellular_component	U2 snRNP
w	0006397	biological_process	mRNA processing
w	0008270	molecular_function	zinc ion binding
w	0008380	biological_process	RNA splicing
w	0016607	cellular_component	nuclear speck
w	0046872	molecular_function	metal ion binding
w	0071005	cellular_component	U2-type precatalytic spliceosome
w	0071013	cellular_component	catalytic step 2 spliceosome
w	1903241	biological_process	U2-type prespliceosome assembly
x	0000398	biological_process	mRNA splicing, via spliceosome
x	0000932	cellular_component	P-body
x	0003723	molecular_function	RNA binding
x	0005515	molecular_function	protein binding
x	0005634	cellular_component	nucleus
x	0005654	cellular_component	nucleoplasm
x	0005681	cellular_component	spliceosomal complex
x	0005688	cellular_component	U6 snRNP
x	0005730	cellular_component	nucleolus
x	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
x	0005737	cellular_component	cytoplasm
x	0005829	cellular_component	cytosol
x	0006364	biological_process	rRNA processing
x	0006397	biological_process	mRNA processing
x	0006402	biological_process	mRNA catabolic process
x	0008033	biological_process	tRNA processing
x	0008380	biological_process	RNA splicing
x	0030490	biological_process	maturation of SSU-rRNA
x	0030532	cellular_component	small nuclear ribonucleoprotein complex
x	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
x	0046982	molecular_function	protein heterodimerization activity
x	0071005	cellular_component	U2-type precatalytic spliceosome
x	0120114	cellular_component	Sm-like protein family complex
x	0120115	cellular_component	Lsm2-8 complex
x	1990904	cellular_component	ribonucleoprotein complex
y	0000398	biological_process	mRNA splicing, via spliceosome
y	0000956	biological_process	nuclear-transcribed mRNA catabolic process
y	0003723	molecular_function	RNA binding
y	0005515	molecular_function	protein binding
y	0005634	cellular_component	nucleus
y	0005654	cellular_component	nucleoplasm
y	0005681	cellular_component	spliceosomal complex
y	0005688	cellular_component	U6 snRNP
y	0005689	cellular_component	U12-type spliceosomal complex
y	0005829	cellular_component	cytosol
y	0006397	biological_process	mRNA processing
y	0008380	biological_process	RNA splicing
y	0017070	molecular_function	U6 snRNA binding
y	0043229	cellular_component	intracellular organelle
y	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
y	0071004	cellular_component	U2-type prespliceosome
y	0071005	cellular_component	U2-type precatalytic spliceosome
y	0071013	cellular_component	catalytic step 2 spliceosome
y	0097526	cellular_component	spliceosomal tri-snRNP complex
y	0120115	cellular_component	Lsm2-8 complex
y	1990726	cellular_component	Lsm1-7-Pat1 complex
y	1990904	cellular_component	ribonucleoprotein complex
z	0000398	biological_process	mRNA splicing, via spliceosome
z	0003723	molecular_function	RNA binding
z	0003729	molecular_function	mRNA binding
z	0005515	molecular_function	protein binding
z	0005634	cellular_component	nucleus
z	0005654	cellular_component	nucleoplasm
z	0005681	cellular_component	spliceosomal complex
z	0005688	cellular_component	U6 snRNP
z	0006397	biological_process	mRNA processing
z	0008380	biological_process	RNA splicing
z	0017070	molecular_function	U6 snRNA binding
z	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
z	0071005	cellular_component	U2-type precatalytic spliceosome
z	0071011	cellular_component	precatalytic spliceosome
z	0120115	cellular_component	Lsm2-8 complex
z	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue IHP A 3000

Chain	Residue
A	LYS442
A	TYR580
A	HIS584
A	LYS606
A	LYS609
A	HIS610
A	TYR613
A	LYS623

---

site_id	AC2
Number of Residues	20
Details	binding site for residue GTP C 1500

Chain	Residue
C	LEU138
C	HIS139
C	GLY141
C	LYS142
C	THR143
C	CYS144
C	VAL179
C	GLY180
C	THR205
C	PRO206
C	GLY207
C	LYS259
C	ASP261
C	ARG262
C	SER311
C	SER312
C	GLN313
C	TYR314
C	MG1501
A	PRO335

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MG C 1501

Chain	Residue
C	THR143
C	ASP204
C	GTP1500

---

Functional Information from PROSITE/UniProt

site_id	PS01159
Number of Residues	26
Details	WW_DOMAIN_1 WW/rsp5/WWP domain signature. WvegitsegyhyYYdlisga.SQWEKP

Chain	Residue	Details
X	TRP128-PRO153
X	TRP169-PRO194

---

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CedknVPYvfVrSKqaLG

Chain	Residue	Details
M	CYS73-GLY90

---

site_id	PS00436
Number of Residues	12
Details	PEROXIDASE_2 Peroxidases active site signature. TVrvARVmWHPS

Chain	Residue	Details
K	THR323-SER334

---

site_id	PS00028
Number of Residues	23
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cnv..CdcvVkdsinfldHingkkH

Chain	Residue	Details
8	CYS82-HIS104

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH

Chain	Residue	Details
3	PHE287-HIS293

---

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgStFHRVIkdFMiQGG

Chain	Residue	Details
W	TYR60-GLY77

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LASAgfDrLILLWNV

Chain	Residue	Details
E	LEU81-VAL95
E	LEU124-SER138
E	VAL167-ILE181
E	ILE208-LEU222
E	ILE300-THR314
K	LEU338-LEU352
K	ILE422-LEU436
Y	LEU229-PHE243
Y	ILE364-MET378

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541, ECO:0000269|PubMed:23045696, ECO:0007744|PDB:4F93

Chain	Residue	Details
D	ALA503
6	CYS72
6	CYS75
6	CYS85
D	ALA1350
2	ARG247
2	ARG515
6	CYS33
6	CYS46
6	CYS49
6	CYS58
6	CYS61

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
D	SER17
3	LYS1171
P	SER9
9	SER789

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER26
1	CYS677
1	GLU1205
8	LYS39
8	LYS55
8	LYS61
8	LYS70
8	LYS102
8	LYS123

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19367720, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
D	SER225
1	THR235
1	THR426
k	LYS6
k	LYS8
P	LYS6
P	LYS8

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	THR389
D	THR1428
w	SER369

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:F1LNJ2

Chain	Residue	Details
D	TYR709
1	LYS554
1	LYS562

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
D	LYS971
2	SER861

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q6P4T2

Chain	Residue	Details
D	THR1765
2	SER362
9	SER598

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER2002
2	SER435
2	SER436

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
D	THR2131
u	LYS131
u	LYS424
u	LYS499
0	LYS381
0	LYS415
0	LYS418

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
D	SER2133
D	SER2135
L	LYS478

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
D	LYS46
9	LYS648
9	LYS657
9	LYS684
9	LYS699
9	LYS709
9	LYS723
9	LYS749
9	LYS758
9	LYS775
9	LYS780
9	LYS791
2	LYS280
2	LYS492
2	LYS543
2	LYS770
2	LYS790
2	LYS843
2	LYS857

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
2	LYS400

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733

Chain	Residue	Details
2	LYS412
9	LYS188

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	THR227

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q99NB9

Chain	Residue	Details
1	SER229

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:12105215

Chain	Residue	Details
1	THR244

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000305|PubMed:12105215

Chain	Residue	Details
1	THR248

---

site_id	SWS_FT_FI19
Number of Residues	5
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
1	THR257
1	THR261
1	THR278
1	THR303
1	THR313

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
1	THR267

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
1	THR273

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
1	SER287

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	THR296

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983

Chain	Residue	Details
1	THR299

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	SER322

---

site_id	SWS_FT_FI26
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	THR326

---

site_id	SWS_FT_FI27
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231

Chain	Residue	Details
1	THR328

---

site_id	SWS_FT_FI28
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	SER332

---

site_id	SWS_FT_FI29
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692

Chain	Residue	Details
1	THR341

---

site_id	SWS_FT_FI30
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
1	SER344

---

site_id	SWS_FT_FI31
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692

Chain	Residue	Details
1	SER349

---

site_id	SWS_FT_FI32
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	THR350
1	THR436

---

site_id	SWS_FT_FI33
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	THR354

---

site_id	SWS_FT_FI34
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	SER400

---

site_id	SWS_FT_FI35
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by DYRK1A => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	THR434

---

site_id	SWS_FT_FI36
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
1	SER488

---

site_id	SWS_FT_FI37
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
1	LYS214

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site_id	SWS_FT_FI38
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
1	LYS430

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site_id	SWS_FT_FI39
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733

Chain	Residue	Details
1	LYS413

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