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6AHD

The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1APre-mRNA-processing-splicing factor 8polymer2335273974.31UniProt (Q6P2Q9)
Pfam (PF08082)
Pfam (PF08083)
Pfam (PF10598)
Pfam (PF10597)
Pfam (PF10596)
Pfam (PF12134)
Pfam (PF01398)
Pfam (PF08084)
In PDB
Homo sapiens (Human)220 kDa U5 snRNP-specific protein,PRP8 homolog,Splicing factor Prp8,p220
2IU4snRNApolymer14446181.31GenBank (340142)Homo sapiens (Human)
3BU5snRNApolymer11737254.91GenBank (20330981)Homo sapiens (Human)
4FU6snRNApolymer10734404.41Homo sapiens (Human)
5Gpre-mRNApolymer27487892.71Homo sapiens (Human)
6OThioredoxin-like protein 4Apolymer14216807.31UniProt (P83876)
Pfam (PF02966)
In PDB
Homo sapiens (Human)DIM1 protein homolog,Spliceosomal U5 snRNP-specific 15 kDa protein,Thioredoxin-like U5 snRNP protein U5-15kD
7C116 kDa U5 small nuclear ribonucleoprotein componentpolymer972109560.61UniProt (Q15029)
Pfam (PF16004)
Pfam (PF00009)
Pfam (PF03144)
Pfam (PF14492)
Pfam (PF03764)
Pfam (PF00679)
In PDB
Homo sapiens (Human)Elongation factor Tu GTP-binding domain-containing protein 2,SNU114 homolog,hSNU114,U5 snRNP-specific protein,116 kDa,U5-116 kDa
8NPre-mRNA-processing factor 6polymer941107092.21UniProt (O94906)
Pfam (PF06424)
Pfam (PF14559)
Pfam (PF13181)
In PDB
Homo sapiens (Human)Androgen receptor N-terminal domain-transactivating protein 1,ANT-1,PRP6 homolog,U5 snRNP-associated 102 kDa protein,U5-102 kDa protein
9MNHP2-like protein 1polymer12814191.51UniProt (P55769)
Pfam (PF01248)
In PDB
Homo sapiens (Human)High mobility group-like nuclear protein 2 homolog 1,OTK27,SNU13 homolog,hSNU13,U4/U6.U5 small nuclear ribonucleoprotein SNU13,U4/U6.U5 tri-snRNP 15.5 kDa protein
10LU4/U6 small nuclear ribonucleoprotein Prp31polymer49955529.01UniProt (Q8WWY3)
Pfam (PF01798)
Pfam (PF09785)
In PDB
Homo sapiens (Human)Pre-mRNA-processing factor 31,Serologically defined breast cancer antigen NY-BR-99,U4/U6 snRNP 61 kDa protein,hPrp31
119U4/U6.U5 tri-snRNP-associated protein 1polymer80090414.11UniProt (O43290)
Pfam (PF19252)
Pfam (PF03343)
In PDB
Homo sapiens (Human)SNU66 homolog,hSnu66,Squamous cell carcinoma antigen recognized by T-cells 1,hSART-1,U4/U6.U5 tri-snRNP-associated 110 kDa protein
12JU4/U6 small nuclear ribonucleoprotein Prp3polymer68377669.21UniProt (O43395)
Pfam (PF01480)
Pfam (PF08572)
Pfam (PF06544)
In PDB
Homo sapiens (Human)Pre-mRNA-splicing factor 3,hPrp3,U4/U6 snRNP 90 kDa protein
13a, i, USmBpolymer23123686.03Homo sapiens (Human)
14b, j, VSmall nuclear ribonucleoprotein Sm D1polymer11913310.73UniProt (P62314)
Pfam (PF01423)
In PDB
Homo sapiens (Human)Sm-D1,Sm-D autoantigen,snRNP core protein D1
15c, k, PSmall nuclear ribonucleoprotein Sm D2polymer11813551.93UniProt (P62316)
Pfam (PF01423)
In PDB
Homo sapiens (Human)Sm-D2,snRNP core protein D2
16d, l, QSmEpolymer869734.23Homo sapiens (Human)
17e, m, RSmFpolymer9210817.63Homo sapiens (Human)
18f, n, SSmall nuclear ribonucleoprotein Gpolymer768508.13UniProt (P62308)
Pfam (PF01423)
In PDB
Homo sapiens (Human)snRNP-G,Sm protein G,SmG
19g, h, TSmall nuclear ribonucleoprotein Sm D3polymer12613940.33UniProt (P62318)
Pfam (PF01423)
In PDB
Homo sapiens (Human)Sm-D3,snRNP core protein D3
20EU5 small nuclear ribonucleoprotein 40 kDa proteinpolymer35739359.51UniProt (Q96DI7)
Pfam (PF00400)
In PDB
Homo sapiens (Human)U5-40K,38 kDa-splicing factor,Prp8-binding protein,hPRP8BP,U5 snRNP-specific 40 kDa protein,WD repeat-containing protein 57
21XWW domain-binding protein 4polymer37642575.81UniProt (O75554)
Pfam (PF06220)
Pfam (PF00397)
In PDB
Homo sapiens (Human)WBP-4,Formin-binding protein 21,WW domain-containing-binding protein 4
22WPeptidyl-prolyl cis-trans isomerase Hpolymer17719230.11UniProt (O43447)
Pfam (PF00160)
In PDB
Homo sapiens (Human)PPIase H,Rotamase H,Small nuclear ribonucleoprotein particle-specific cyclophilin H,CypH,U-snRNP-associated cyclophilin SnuCyp-20,USA-CYP
23A0Ubiquitin-like protein 5polymer738560.91UniProt (Q9BZL1)
Pfam (PF00240)
In PDB
Homo sapiens (Human)
240Microfibrillar-associated protein 1polymer43952050.51UniProt (P55081)
Pfam (PF06991)
In PDB
Homo sapiens (Human)Spliceosome B complex protein MFAP1
25ZPre-mRNA-splicing factor 38Apolymer31237563.91UniProt (Q8NAV1)
Pfam (PF03371)
Pfam (PF12871)
In PDB
Homo sapiens (Human)
268Zinc finger matrin-type protein 2polymer19923664.01UniProt (Q96NC0)
Pfam (PF12171)
In PDB
Homo sapiens (Human)
27YWD40 repeat-containing protein SMU1polymer51357616.71UniProt (Q2TAY7)
Pfam (PF17814)
Pfam (PF00400)
In PDB
Homo sapiens (Human)Smu-1 suppressor of mec-8 and unc-52 protein homolog
28HU2snRNApolymer18860186.41GenBank (340097)Homo sapiens (Human)
29oU2 small nuclear ribonucleoprotein A'polymer25528456.61UniProt (P09661)
Pfam (PF14580)
In PDB
Homo sapiens (Human)U2 snRNP A'
30pU2 small nuclear ribonucleoprotein B''polymer22525524.41UniProt (P08579)
Pfam (PF00076)
In PDB
Homo sapiens (Human)U2 snRNP B''
31uSplicing factor 3A subunit 1polymer79388991.11UniProt (Q15459)
Pfam (PF01805)
Pfam (PF12230)
Pfam (PF00240)
In PDB
Homo sapiens (Human)SF3a120,Spliceosome-associated protein 114,SAP 114
32vSplicing factor 3A subunit 2polymer46449327.41UniProt (Q15428)
Pfam (PF12874)
Pfam (PF16835)
In PDB
Homo sapiens (Human)SF3a66,Spliceosome-associated protein 62,SAP 62
33wSplicing factor 3A subunit 3polymer50158934.81UniProt (Q12874)
Pfam (PF12108)
Pfam (PF16837)
Pfam (PF13297)
Pfam (PF11931)
In PDB
Homo sapiens (Human)SF3a60,Spliceosome-associated protein 61,SAP 61
34qU6 snRNA-associated Sm-like protein LSm2polymer9510847.51UniProt (Q9Y333)
Pfam (PF01423)
In PDB
Homo sapiens (Human)Protein G7b,Small nuclear ribonuclear protein D homolog,snRNP core Sm-like protein Sm-x5
35rU6 snRNA-associated Sm-like protein LSm3polymer10211859.41UniProt (P62310)
Pfam (PF01423)
In PDB
Homo sapiens (Human)
36sU6 snRNA-associated Sm-like protein LSm4polymer13915375.81UniProt (Q9Y4Z0)
Pfam (PF01423)
In PDB
Homo sapiens (Human)Glycine-rich protein,GRP
37tU6 snRNA-associated Sm-like protein LSm5polymer919945.41UniProt (Q9Y4Y9)
Pfam (PF01423)
In PDB
Homo sapiens (Human)
38xU6 snRNA-associated Sm-like protein LSm6polymer809139.61UniProt (P62312)
Pfam (PF01423)
In PDB
Homo sapiens (Human)
39yU6 snRNA-associated Sm-like protein LSm7polymer10311617.41UniProt (Q9UK45)
Pfam (PF01423)
In PDB
Homo sapiens (Human)
40zU6 snRNA-associated Sm-like protein LSm8polymer9610410.61UniProt (O95777)
Pfam (PF01423)
In PDB
Homo sapiens (Human)
41KU4/U6 small nuclear ribonucleoprotein Prp4polymer52258536.11UniProt (O43172)
Pfam (PF08799)
Pfam (PF00400)
In PDB
Homo sapiens (Human)Sm-D1,Sm-D autoantigen,snRNP core protein D1
421Splicing factor 3B subunit 1polymer1304146024.91UniProt (O75533)
Pfam (PF08920)
In PDB
Homo sapiens (Human)Prp4, Sm-D1,Sm-D autoantigen,snRNP core protein D1
433Splicing factor 3B subunit 3polymer1217135718.81UniProt (Q15393)
Pfam (PF10433)
Pfam (PF03178)
In PDB
Homo sapiens (Human)SF3b155, Sm-D1,Sm-D autoantigen,snRNP core protein D1
445SF3b14a, Splicing factor 3B subunit 6polymer12514606.91UniProt (Q9Y3B4)
Pfam (PF00076)
In PDB
Homo sapiens (Human)Spliceosome-associated protein, 14-kDa Splicing factor 3b, subunit 6
456PHD finger-like domain-containing protein 5Apolymer11012427.51UniProt (Q7RTV0)
Pfam (PF03660)
In PDB
Homo sapiens (Human)PHD finger-like domain protein 5A, Splicing factor 3B-associated 14 kDa protein, SF3b14b
467SF3b5, Splicing factor 3B subunit 5polymer8610149.41UniProt (Q9BWJ5)
Pfam (PF07189)
In PDB
Homo sapiens (Human)Pre-mRNA-splicing factor SF3b 10 kDa subunit
472SF3b145, Splicing factor 3B subunit 2polymer895100377.81UniProt (Q13435)
Pfam (PF02037)
Pfam (PF04037)
Pfam (PF04046)
In PDB
Homo sapiens (Human)Pre-mRNA-splicing factor SF3b 145 kDa subunit, Spliceosome-associated protein 145, SAP 145
484SF3b49, Splicing factor 3B subunit 4polymer42444436.61UniProt (Q15427)
Pfam (PF00076)
In PDB
Homo sapiens (Human)Pre-mRNA-splicing factor SF3b 49 kDa subunit, Spliceosome-associated protein 49, SAP 49
49DBrr2, U5 small nuclear ribonucleoprotein 200 kDa helicasepolymer2136244823.41UniProt (O75643)
Pfam (PF21188)
Pfam (PF18149)
Pfam (PF00270)
Pfam (PF00271)
Pfam (PF02889)
In PDB
Homo sapiens (Human)BRR2 homolog, U5 snRNP-specific 200 kDa protein, U5-200KD
50AINOSITOL HEXAKISPHOSPHATEnon-polymer660.01Chemie (IHP)
51CGUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
52CMAGNESIUM IONnon-polymer24.31Chemie (MG)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains63
Total formula weight2669957.2
Non-Polymers*Number of molecules3
Total formula weight1207.5
All*Total formula weight2671164.7
*Water molecules are not included.

217705

PDB entries from 2024-03-27

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