3HLL

Crystal Structure of Human p38alpha complexed with PH-797804

Summary for 3HLL

• Entry DOI: 10.2210/pdb3hll/pdb
• Related: 3HL7
• Descriptor: Mitogen-activated protein kinase 14, 3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl}-N,4-dimethylbenzamide, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, ... (5 entities in total)
• Functional Keywords: atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): Q16539
• Total number of polymer chains: 1
• Total formula weight: 42140.70

Authors

Shieh, H.-S.,Williams, J.M.,Stegeman, R.A.,Kurumbail, R.G. (deposition date: 2009-05-27, release date: 2009-07-14, Last modification date: 2011-07-13)

• Primary citation: Xing, L.,Shieh, H.S.,Selness, S.R.,Devraj, R.V.,Walker, J.K.,Devadas, B.,Hope, H.R.,Compton, R.P.,Schindler, J.F.,Hirsch, J.L.,Benson, A.G.,Kurumbail, R.G.,Stegeman, R.A.,Williams, J.M.,Broadus, R.M.,Walden, Z.,Monahan, J.B.; Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804.; Biochemistry, 48:6402-6411, 2009; PubMed: 19496616; DOI: 10.1021/bi900655f

Experimental method

X-RAY DIFFRACTION (1.95 Å)