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PDB: 198 results
4WTD
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CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH ADP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AUAAAUUU
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MANGANESE (II) ION, ...
Authors:Edwards, T.E, Fox III, D, Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTF
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BU of 4wtf by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH GS-639475, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU
Descriptor: 2'-C-methyluridine 5'-(trihydrogen diphosphate), CHLORIDE ION, MANGANESE (II) ION, ...
Authors:Edwards, T.E, Appleby, T.C, Mcgrath, M.E.
Deposit date:2014-10-30
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTA
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CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH UDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU
Descriptor: CHLORIDE ION, MANGANESE (II) ION, RNA PRIMER TEMPLATE CAAAAUUU, ...
Authors:Edwards, T.E, Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTC
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BU of 4wtc by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH CDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AGAAAUUU
Descriptor: CHLORIDE ION, CYTIDINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Edwards, T.E, Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTE
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BU of 4wte by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH GDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-ACAAAUUU
Descriptor: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Edwards, T.E, Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTG
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BU of 4wtg by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH SOFOSBUVIR DIPHOSPHATE GS-607596, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU
Descriptor: 2'-deoxy-2'-fluoro-2'-methyluridine 5'-(trihydrogen diphosphate), CHLORIDE ION, MANGANESE (II) ION, ...
Authors:Edwards, T.E, Appleby, T.C.
Deposit date:2014-10-30
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTJ
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BU of 4wtj by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-AUCC, RNA PRIMER 5'-PGG, MN2+, AND ADP
Descriptor: 1,2-ETHANEDIOL, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Edwards, T.E, Appleby, T.C.
Deposit date:2014-10-30
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTM
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BU of 4wtm by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-UAGG, RNA PRIMER 5'-PCC, MN2+, AND UDP
Descriptor: CHLORIDE ION, MANGANESE (II) ION, RNA PRIMER CC, ...
Authors:Edwards, T.E, Appleby, T.C, Fox III, D.
Deposit date:2014-10-30
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTI
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BU of 4wti by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-ACGG, RNA PRIMER 5'-PCC, MN2+, AND GDP
Descriptor: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Edwards, T.E, Appleby, T.C.
Deposit date:2014-10-30
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTK
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BU of 4wtk by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-AGCC, RNA PRIMER 5'-PGG, MN2+, AND CDP
Descriptor: 1,2-ETHANEDIOL, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Edwards, T.E, Appleby, T.C.
Deposit date:2014-10-30
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTL
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BU of 4wtl by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-UACC, RNA PRIMER 5'-PGG, MN2+, AND UDP
Descriptor: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
Authors:Edwards, T.E, Appleby, T.C.
Deposit date:2014-10-30
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WT9
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BU of 4wt9 by Molmil
APO CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH E86Q E87Q S15G C223H V321I AND DELTA8 MUTATIONS
Descriptor: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ...
Authors:Edwards, T.E, Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
1Q7F
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BU of 1q7f by Molmil
Brain Tumor NHL domain
Descriptor: brain tumor CG10719-PA
Authors:Edwards, T.A, Wilkinson, B.D, Wharton, R.P, Aggarwal, A.K.
Deposit date:2003-08-18
Release date:2003-10-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Model of the Brain Tumor-Pumilio translation repressor complex
Genes Dev., 17, 2003
6UGK
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BU of 6ugk by Molmil
CRYSTAL STRUCTURE OF CIRCULARLY PERMUTED HUMAN TASPASE-1
Descriptor: CHLORIDE ION, SODIUM ION, Threonine aspartase 1,Threonine aspartase 1
Authors:Edwards, T.E, Delker, S.L.
Deposit date:2019-09-26
Release date:2021-03-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural insights into the function of the catalytically active human Taspase1.
Structure, 29, 2021
5UJ2
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BU of 5uj2 by Molmil
Crystal structure of HCV NS5B genotype 2A JFH-1 isolate with S15G E86Q E87Q C223H V321I mutations and Delta8 neta hairpoin loop deletion in complex with GS-639476 (diphsohate version of GS-9813), Mn2+ and symmetrical primer template 5'-AUAAAUUU
Descriptor: (1S)-1-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-1,4-anhydro-2-deoxy-2-fluoro-5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-2-methyl-D-ribitol, CHLORIDE ION, Genome polyprotein, ...
Authors:Edwards, T.E, Fox III, D, Appleby, T.C, Murakami, E, Rey, A, McGrath, M.E.
Deposit date:2017-01-16
Release date:2017-03-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Bioorg. Med. Chem. Lett., 27, 2017
4E7A
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BU of 4e7a by Molmil
Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin deletion bound to primer-template RNA with a 2',3'-ddC
Descriptor: 5'-R(*CP*AP*UP*GP*GP*C)-D(P*(DOC))-3', RNA-directed RNA polymerase
Authors:Edwards, T.E, Mosley, R.T.
Deposit date:2012-03-16
Release date:2012-04-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of hepatitis C virus polymerase in complex with primer-template RNA.
J.Virol., 86, 2012
6AQ3
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BU of 6aq3 by Molmil
Crystal structure of a trafficking protein particle complex subunit 3 from Naegleria fowleri covalently bound to palmitic acid
Descriptor: 1,2-ETHANEDIOL, PALMITIC ACID, trafficking protein particle complex subunit 3
Authors:Edwards, T.E, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-08-18
Release date:2017-08-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of a trafficking protein particle complex subunit 3 from Naegleria fowleri covalently bound to palmitic acid
To Be Published
6AY1
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BU of 6ay1 by Molmil
Crystal structure of a nucleoside diphosphate kinase NDK from Helicobacter pylori
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, HEXANE-1,6-DIOL, ISOPROPYL ALCOHOL, ...
Authors:Edwards, T.E, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-09-07
Release date:2017-09-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of a nucleoside diphosphate kinase NDK from Helicobacter pylori
To be Published
6G0Y
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BU of 6g0y by Molmil
X-ray structure of M-21 protein complex
Descriptor: Matrix M2-1, Phosphoprotein, ZINC ION
Authors:Edwards, T.A, Barr, J.
Deposit date:2018-03-20
Release date:2018-11-14
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex.
Mbio, 9, 2018
4OBC
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BU of 4obc by Molmil
Crystal structure of HCV polymerase NS5b genotype 2a JFH-1 isolate with the S15G, C223H, V321I resistance mutations against the guanosine analog GS-0938 (PSI-3529238)
Descriptor: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ...
Authors:Edwards, T.E, Abendroth, J, Appleby, T.C.
Deposit date:2014-01-07
Release date:2014-09-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance.
Antimicrob.Agents Chemother., 58, 2014
4E78
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BU of 4e78 by Molmil
Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin loop deletion bound to primer-template RNA with 3'-dG
Descriptor: 5'-R(*U*AP*CP*CP*GP*(GDO))-3', PROTEIN (RNA-directed RNA polymerase)
Authors:Edwards, T.E, Mosley, R.T.
Deposit date:2012-03-16
Release date:2012-04-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of hepatitis C virus polymerase in complex with primer-template RNA.
J.Virol., 86, 2012
4E76
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BU of 4e76 by Molmil
Apo crystal structure of HCV NS5B genotype 2A JFH-1 isolate with beta hairpin loop deletion
Descriptor: 1,2-ETHANEDIOL, RNA-directed RNA polymerase, SULFATE ION
Authors:Edwards, T.E, Mosley, R.T.
Deposit date:2012-03-16
Release date:2012-04-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of hepatitis C virus polymerase in complex with primer-template RNA.
J.Virol., 86, 2012
6AMZ
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BU of 6amz by Molmil
Crystal structure of a domain swapped 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Acinetobacter baumannii
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, CALCIUM ION
Authors:Edwards, T.E, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-08-11
Release date:2017-08-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of a domain swapped 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Acinetobacter baumannii
To Be Published
6CTC
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BU of 6ctc by Molmil
Crystal structure of human transferrin bound to Triferic FPC iron pyrophosphate
Descriptor: CARBONATE ION, FE (III) ION, PYROPHOSPHATE 2-, ...
Authors:Edwards, T.E, Pratt, R.
Deposit date:2018-03-22
Release date:2018-10-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Ferric pyrophosphate citrate: interactions with transferrin.
Biometals, 31, 2018
4QFD
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BU of 4qfd by Molmil
Co-crystal structure of compound 2 (3-(7-hydroxy-2-oxo-4-phenyl-2H-chromen-6-yl)propanoic acid) and FAD bound to human DAAO at 2.85A
Descriptor: 3-(7-hydroxy-2-oxo-4-phenyl-2H-chromen-6-yl)propanoic acid, D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Edwards, T.E, Chun, L, Arakaki, T.L.
Deposit date:2014-05-20
Release date:2014-07-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Novel human D-amino acid oxidase inhibitors stabilize an active-site lid-open conformation.
Biosci.Rep., 34, 2014

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