4E78
Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin loop deletion bound to primer-template RNA with 3'-dG
Summary for 4E78
Entry DOI | 10.2210/pdb4e78/pdb |
Related | 4E76 4E7A |
Descriptor | 5'-R(*U*AP*CP*CP*GP*(GDO))-3', PROTEIN (RNA-directed RNA polymerase) (3 entities in total) |
Functional Keywords | rdrp, loopless delta8, ternary complex, product complex, flaviviridae, hepatitis c virus, viral protein, transferase-rna complex, transferase/rna |
Biological source | Hepatitis C virus (HCV) More |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : Q99IB8 |
Total number of polymer chains | 3 |
Total formula weight | 67486.58 |
Authors | Edwards, T.E.,Mosley, R.T. (deposition date: 2012-03-16, release date: 2012-04-18, Last modification date: 2023-09-13) |
Primary citation | Mosley, R.T.,Edwards, T.E.,Murakami, E.,Lam, A.M.,Grice, R.L.,Du, J.,Sofia, M.J.,Furman, P.A.,Otto, M.J. Structure of hepatitis C virus polymerase in complex with primer-template RNA. J.Virol., 86:6503-6511, 2012 Cited by PubMed: 22496223DOI: 10.1128/JVI.00386-12 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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