4E78
Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin loop deletion bound to primer-template RNA with 3'-dG
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | T, P | 5'-R(*U*AP*CP*CP*GP*(GDO))-3' | polymer | 6 | 1875.2 | 2 | |||
2 | A | PROTEIN (RNA-directed RNA polymerase) | polymer | 572 | 63736.2 | 1 | UniProt (Q99IB8) Pfam (PF00998) In PDB | Hepatitis C virus (HCV) | NS5B, p68 |
3 | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
A: 1 - 443 (UniProt: Q99IB8)
A: 454 - 570 (UniProt: Q99IB8)
PDB | External Database | Details |
---|---|---|
Met -1 | - | expression tag |
Ser 0 | - | expression tag |
Gln 86 | Glu 2528 | engineered mutation |
Gln 87 | Glu 2529 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 444 | - | linker |
Gly 445 | - | linker |
Leu 571 | - | expression tag |
Glu 572 | - | expression tag |
His 573 | - | expression tag |
His 574 | - | expression tag |
His 575 | - | expression tag |
His 576 | - | expression tag |
His 577 | - | expression tag |
His 578 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 67486.6 | |
All* | Total formula weight | 67486.6 |