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4QFD

Co-crystal structure of compound 2 (3-(7-hydroxy-2-oxo-4-phenyl-2H-chromen-6-yl)propanoic acid) and FAD bound to human DAAO at 2.85A

Summary for 4QFD
Entry DOI10.2210/pdb4qfd/pdb
Related4QFC
DescriptorD-amino-acid oxidase, SODIUM ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
Functional Keywordsoxidase, oxidoreductase, daao, d-amino acid oxidase, d-serine competitive, schizophrenia, nmda receptor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationPeroxisome: P14920
Total number of polymer chains2
Total formula weight81279.50
Authors
Edwards, T.E.,Chun, L.,Arakaki, T.L. (deposition date: 2014-05-20, release date: 2014-07-16, Last modification date: 2023-09-20)
Primary citationTerry-Lorenzo, R.T.,Chun, L.E.,Brown, S.P.,Heffernan, M.L.,Fang, Q.K.,Orsini, M.A.,Pollegioni, L.,Hardy, L.W.,Spear, K.L.,Large, T.H.
Novel human D-amino acid oxidase inhibitors stabilize an active-site lid-open conformation.
Biosci.Rep., 34:-, 2014
Cited by
PubMed: 25001371
DOI: 10.1042/BSR20140071
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.85 Å)
Structure validation

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